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Journal of Assisted Reproduction and Genetics

Erschienen in:

01.03.2014 | Genetics

Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

verfasst von: Chen Zong, Yanwei Sha, Huifen Xiang, Jing Wang, Dawei Chen, Juan Liu, Binbin Wang, Yunxia Cao

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 3/2014

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Abstract

Objective

Recurrent spontaneous abortion (RSA) is a multifactor and distressing disease. There are still approximately half of the RSA patients with cause not being identified to date. Accumulating studies have confirmed that genetic polymorphisms in glutathione S-transferases (GSTs) were associated with the risk of recurrent spontaneous abortion. In this study, we aimed to investigate the relationship between the polymorphism of GSTA1, which is GSTA1 -69C/T (rs3957357), and the development of recurrent spontaneous abortion.

Methods

A case–control study of 127 cases with RSA and 112 ethnic and age matched women as controls was conducted. And measurement of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was performed to genotype all of samples in order to analyze the association between GSTA1 -69C/T (rs3957357) and the risk of RSA.

Results

We found that the frequencies of genotypes between cases and controls have no significant difference (P = 0.908) and GSTA1 mutant allele GSTA1 −69 T was present at a frequency of 0.122 in case group, while in controls the frequency was 0.125 (P = 0.922).

Conclusion

The polymorphism of GSTA1 (rs3957357) may not be associated with the risk of recurrent spontaneous abortion in Chinese Han population.

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Titel: Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population
verfasst von: Chen Zong
Yanwei Sha
Huifen Xiang
Jing Wang
Dawei Chen
Juan Liu
Binbin Wang
Yunxia Cao
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 3/2014
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-0163-2

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