nach oben

Lasers in Medical Science

Erschienen in:

01.10.2020 | Original Article

Gold nanorod–loaded (PLGA-PEG) nanocapsules as near-infrared controlled release model of anticancer therapeutics

verfasst von: Wael Mahmoud Ahmed Darwish, Noha A. Bayoumi

Erschienen in: Lasers in Medical Science | Ausgabe 8/2020

Einloggen, um Zugang zu erhalten

Abstract

Despite of high in vitro anticancer efficacy of many chemotherapeutics, their in vivo use is limited due to lack of biocompatibility and tumor targeting. Near-infrared (NIR) photothermally induced phase transition of PLGA-PEG regime was utilized for developing highly efficient photoresponsive drug delivery systems. Co-encapsulation of plasmonic gold nanorods (GNRs), as NIR-trigger, with the novel and highly efficient anticancer drug N′-(2-Methoxybenzylidene)-3-methyl-1-phenyl-H-Thieno[2,3-c]Pyrazole-5-Carbohyd-razide (MTPC) produced NIR-responsive biodegradable polymeric (PLGA-b-PEG) nanocapsules. This remotely controllable drug release significantly enhanced both biodistribution and pharmacokinetics of the hydrophobic drug. Intravenous (IV) injection of the prepared nanocapsules (MTPC/GNRs@PLGA-PEG) to tumor-bearing mice followed by extracorporeal exposure of the tumor to NIR light resulted in highly selective drug accumulation at the tumor sites. In vivo biodistribution and pharmacokinetics utilizing iodine-131 drug-radiolabelling technique revealed a maximum target to non-target ratio (T/NT) of 5.8, 4 h post-injection with maximum drug level in the tumor (6.3 ± 0.6% of the injected dose).

Nur mit Berechtigung zugänglich

Fayad W, Rickardson L, Haglund C et al (2011) Identification of agents that induce apoptosis of multicellular tumor spheroids: enrichment for mitotic inhibitors with hydrophobic properties. Chem Biol Drug Des 78:547–557CrossRef

Das M, Sarma A, Chakraborty T (2016) PLGA-derived anticancer nano therapeutics: promises and challenges for the future. J Chem Pharm Res 8:484–499

Lu J, Wang X, Marin-Muller C et al (2009) Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn 9:325–341CrossRef

Acharya S, Sahoo S (2011) PLGA nanoparticles containing various anticancer agents and tumor delivery by EPR effect. Adv Drug Deliv Rev 63:170–183CrossRef

Bilati U, Allemann E, Doelker V (2005) Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. Eur J Pharm Sci 24:67–75CrossRef

Takashima Y, Saito R, Nakajima A et al (2007) Spray-drying preparation of microparticles containing cationic PLGA nanospheres as gene carriers for avoiding aggregation of nanospheres. Int J Pharm 343:262–269CrossRef

Gref R, Minamitake Y, Peracchia M et al (1994) Biodegradable long-circulating polymeric nanospheres. Science 263:1600–1603CrossRef

Chu C-H, Wang Y-C, Tai L-A et al (2010) Surface deformation of gold nanorod-loaded poly (DL-lactide-co-glycolide) nanoparticles after near infrared irradiation: an active and controllable drug release system. J Mater Chem 20:3260–3264CrossRef

Weissleder R (2001) A clearer vision for in vivo imaging. Nat Biotechnol 19:316–317CrossRef

10.

Chuang C-C, Cheng C-C, Chen P-Y et al (2019) Gold nanorod-encapsulated biodegradable polymeric matrix for combined photothermal and chemo-cancer therapy. Int J Nanomedicine 14:181–193CrossRef

11.

You J, Zhang G, Li C (2010) Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release. ACS Nano 4:1033–1041CrossRef

12.

Perrin D, Armarego W (1989) Purification of laboratory chemicals, 2nd edn. Pergamon Press, Oxford

13.

Dickerson E, Dreaden E, Huang X et al (2008) Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Lett 269:57–66CrossRef

14.

Sau T, Murphy C (2004) Seeded high yield synthesis of short Au nanorods in aqueous solution. Langmuir 20:6414–6420CrossRef

15.

Zhang Y, Zhao Q, Shao H, et al. Adv. Mat. Sci. Eng. (2014) 107375

16.

Boddu S, Vaishya R, Jwala J et al (2012) Preparation and characterization of folate conjugated nanoparticles of doxorubicin using PLGA-PEG-FOL. Med Chem 2:68–75CrossRef

17.

Rijcken C, Hofman J, van Zeeland F et al (2007) Photosensitiser-loaded biodegradable polymeric micelles: preparation, characterization and in vitro PDT efficacy. J Control Release 124:144–153CrossRef

18.

Rafiei P, Haddadi A (2017) Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile. Int J Nanomedicine 12:935–947 and references thereinCrossRef

19.

Darwish W, Bayoumi N, El-Kolaly M (2018) Laser-responsive liposome for selective tumor targeting of nitazoxanide nanoparticles. Eur J Pharm Sci 111:526–499CrossRef

20.

Amin A, Soliman S, El-Aziz H (2010) Preparation and biodistribution of [¹²⁵I] Melphalan: a potential radioligand for diagnostic and therapeutic applications. J Label Compd Radiopharm:531–535

21.

Bayoumi N, Amin A, Ismail N et al (2015) Radioiodination and biological evaluation of cladribine as potential agent for tumor imaging, Radiochim. Acta 103:777–787

22.

Kamal K, Anant N, Emilio C et al (2010) In vitro and in vivo evaluation of docetaxel loaded biodegradable polymersomes. Macromol Biosci 10:503–512CrossRef

23.

Arulsudar N, Subramanian N, Mishra P et al (2004) Preparation, characterization, and biodistribution study of technetium-99m labeled leuprolide acetate-loaded liposomes in Ehrlich ascites tumor-bearing mice. AAPS Pharm Sci 6:45–51CrossRef

24.

Derakhshandeh K, Erfan M, Dadashzadeh S (2007) Eur J Pharm Biopharm 66:34–41CrossRef

25.

Zhang H, Cui W, Bei J et al (2006) Preparation of poly (lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behavior in aqueous solution. Polym Degrad Stab 91:1929–1936CrossRef

26.

El-Gogary R, Rubio N, Wang J et al (2014) Polyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivo. ACS Nano 8:1384–1401CrossRef

27.

Koopaei M, Khoshayand M, Mostafavi S et al (2014) Docetaxel loaded PEG-PLGA nanoparticles: optimized drug loading, in-vitro cytotoxicity and in-vivo antitumor effect. Iranian J Pharm Res 13:819–833

28.

Nallamuthu I, Parthasarathi A, Khanum F (2013) Thymoquinone-loaded PLGA nanoparticles: antioxidant and anti-microbial properties. Int Curr Pharm J 2:202–207CrossRef

29.

Song J, Yang X, Jacobson O et al (2015) Ultrasmall gold nanorod vesicles with enhanced tumor accumulation and fast excretion from the body for cancer therapy. Adv Mater 27:4910–4917CrossRef

30.

Ravindran J, Nair H, Sung B et al (2010) Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemo-sensitization potential. Biochem Pharmacol 79:1640–1647CrossRef

31.

Arulsudar N, Subramanian N, Mishra P et al (2003) Preparation, characterization and biodistribution of ^99mTc labeled liposome encapsulated cyclosporine. J Drug Target 11:187–196PubMed

32.

Wang L, Li D, Hao Y et al (2017) Gold nanorod–based poly (lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications. Int J Nanomedicine 12:3059–3075CrossRef

33.

Zhang Y, Poon W, Tavares A et al (2016) Nanoparticle-liver interactions: cellular uptake and hepatobiliary elimination. J Control Release 240:332–348CrossRef

34.

Yoo J, Chambers E, Mitragotri S (2010) Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects. Curr Pharm Des 16:2298–2307CrossRef

35.

Ernsting M, Murakami M, Roy A (2013) Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. J Control Release 172:782–794CrossRef

36.

Hoyt R, Hawkins J, Kennett J (2007) Chapter 2, mouse physiology A2. In: Fox J, Davisson M, Quimby F, Barthold S, Newcomer C, Smith A (eds) The mouse in biomedical research, vol 23-XVI, 2nd edn. Academic Press, Burlington

37.

Jin C, Bai L, Wu H et al (2009) Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells. Pharm Res 26:1776–1784CrossRef

38.

Esmaeili F, Dinarvand R, Ghahremani M et al (2010) Cellular cytotoxicity and in-vivo biodistribution of docetaxel poly (lactide-co-glycolide) nanoparticles. Anti-Cancer Drugs 21:43–52CrossRef

39.

Panagi Z, Beletsi A, Evangelatos G et al (2001) Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA–mPEG nanoparticles. Int J Pharm 221:143–152CrossRef

Titel: Gold nanorod–loaded (PLGA-PEG) nanocapsules as near-infrared controlled release model of anticancer therapeutics
verfasst von: Wael Mahmoud Ahmed Darwish
Noha A. Bayoumi
Publikationsdatum: 01.10.2020
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 8/2020
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-02964-w

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2020

Photobiomodulation as an adjunctive therapy for alveolar socket preservation: a preliminary study in humans

Effects of consumption of contaminated feed with 2,4-dichlorophenoxyacetic acid (2,4-D) on the rat tibia: analysis by Raman spectroscopy and mechanical properties

42 °C heat stress pretreatment protects human melanocytes against 308-nm laser-induced DNA damage in vitro

Prophylactic photobiomodulation therapy using 660 nm diode laser for oral mucositis in paediatric patients under chemotherapy: 5-year experience from a Brazilian referral service

Role of low-level laser therapy in post-herpetic neuralgia: a pilot study

Retrospective study of the treatment of port-wine stains with 595-nm pulsed dye laser in 261 Chinese patients