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Erschienen in: Journal of Natural Medicines 1/2017

01.01.2017 | Original Paper

Green tea cultivar ‘Benifuuki’ potentiates split vaccine-induced immunoglobulin A production

verfasst von: Yeong-Seon Won, Motofumi Kumazoe, Kanako Takamatsu, Yuki Shinoda, Saki Sonoda, Kenji Okada, Takehisa Okamoto, Hirofumi Tachibana

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2017

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Abstract

Influenza is a widespread disease caused by infection with the influenza virus. Vaccination is considered to be the main countermeasure against influenza. A split vaccine is widely used to avoid severe adverse events, and it induces strong humoral immunity. However, the split vaccine alone cannot elicit mucosal immunity, including IgA production, and its preventative effects are limited. Here, we show that the green tea cultivar ‘Benifuuki’ extract enhanced the effect of a split vaccine on mucosal immunity. The frequency of IgA+ cells was increased in lung and Peyer’s patch that received Benifuuki diet. Secretion of hemagglutinin-specific mucosal IgA, which is closely linked to the prevention of viral infection, was significantly increased in the bronchoalveolar lavage fluid of split vaccine-immunized BALB/c mice that were administered green tea Benifuuki extract. Our findings suggest that Benifuuki intake enhanced the effects of the split vaccine on mucosal immunity.
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Metadaten
Titel
Green tea cultivar ‘Benifuuki’ potentiates split vaccine-induced immunoglobulin A production
verfasst von
Yeong-Seon Won
Motofumi Kumazoe
Kanako Takamatsu
Yuki Shinoda
Saki Sonoda
Kenji Okada
Takehisa Okamoto
Hirofumi Tachibana
Publikationsdatum
01.01.2017
Verlag
Springer Japan
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2017
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-016-1028-7

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