Erschienen in:
08.07.2019 | Original Paper
HCV-Related Mortality Among HIV/HCV Co-infected Patients: The Importance of Behaviors in the HCV Cure Era (ANRS CO13 HEPAVIH Cohort)
verfasst von:
Melina Erica Santos, Camelia Protopopescu, Philippe Sogni, Issifou Yaya, Lionel Piroth, François Bailly, Fabienne Marcellin, Laure Esterle, Linda Wittkop, Eric Rosenthal, Philippe Morlat, Perrine Roux, Wildo Navegantes de Araujo, Dominique Salmon-Ceron, Maria Patrizia Carrieri, the ANRS CO13 HEPAVIH Study Group
Erschienen in:
AIDS and Behavior
|
Ausgabe 4/2020
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Abstract
Mortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray’s competing-risk model adjusted for socio-demographic, clinical predictors and confounding factors, while accounting for competing causes of death. Over a 5-year median follow-up period, 77 deaths occurred among 1028 patients. Regular/daily cannabis use, elevated coffee intake, and not currently smoking were independently associated with reduced HCV-mortality (adjusted sub-hazard ratio [95% CI] 0.28 [0.10–0.83], 0.38 [0.15–0.95], and 0.28 [0.10–0.79], respectively). Obesity and severe thinness were associated with increased HCV-mortality (2.44 [1.00–5.93] and 7.25 [2.22–23.6] versus normal weight, respectively). Regular binge drinking was associated with increased non-HCV-mortality (2.19 [1.10–4.37]). Further research is needed to understand the causal mechanisms involved. People living with HIV/HCV co-infection should be referred for tobacco, alcohol and weight control interventions and potential benefits of cannabis-based therapies investigated.