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Current Hematologic Malignancy Reports

Erschienen in:

02.10.2018 | CART and Immunotherapy (M Ruella, Section Editor)

Hematopoietic Stem Cell Transplantation in the Era of Engineered Cell Therapy

verfasst von: Jacob S. Appelbaum, Filippo Milano

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 6/2018

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Abstract

Purpose of Review

Cellular therapy using T cells modified to express chimeric antigen receptors (CAR-T cells) has had striking success in patients that have failed previous treatment for CD19⁺ B cell non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL), or acute lymphoblastic leukemia (ALL). Curative therapy for this group of diseases has previously been limited to allogeneic hematopoietic cell transplantation HCT (alloHCT). The recent results of CAR-T cell therapy raise the question of how best to integrate CAR-T cell therapy and alloHCT in the care of these patients.

Recent Findings

Within the past 2 years, results from larger trials and increased follow-up of patients treated with CD19 CAR-T cell therapy suggest that some may achieve durable remission without transplant.

Summary

The balance of efficacy and toxicity for CAR-T cell therapy and alloHCT vary by disease type, disease status at the time of treatment, patient characteristics, and the specific therapy employed. There are early signals that subsequent transplantation of patients who have achieved remission with CAR-T may be a potentially viable (though expensive) strategy.

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Titel: Hematopoietic Stem Cell Transplantation in the Era of Engineered Cell Therapy
verfasst von: Jacob S. Appelbaum
Filippo Milano
Publikationsdatum: 02.10.2018
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 6/2018
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-018-0476-4

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Online and Social Media Resources for Patients with MDS

Social Media and Hematopoietic Cell Transplantation: a Review of Online Resources and Communities

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) on Social Media: #BPDCN—Increasing Exposure over Two Years Since Inception of a Disease-Specific Twitter Community

Minimal/Measurable Residual Disease Detection in Acute Leukemias by Multiparameter Flow Cytometry

Myelodysplastic Syndromes: Laboratory Workup in the Context of New Concepts and Classification Criteria

Targeted Therapies in CLL: Monotherapy Versus Combination Approaches

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie