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Clinical and Translational Oncology

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01.11.2015 | Research Article

Hepatic arterial infusion plus systemic chemotherapy as third-line or later treatment in colorectal liver metastases

verfasst von: W.-G. Qiang, L.-R. Shi, X.-D. Li, Q.-Q. Wu, J.-M. Zhao, L.-J. Chen, Y. Yang, J. Wu, M. Ji, C.-P. Wu

Erschienen in: Clinical and Translational Oncology | Ausgabe 11/2015

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Abstract

Backgrounds

The present study aimed to evaluate benefit of hepatic arterial infusion chemotherapy (HAI) combined with systemic chemotherapy (SCT) for patients with colorectal liver metastases (CLMs) in a palliative setting.

Methods

This was a retrospective single-center study including 43 consecutive patients with CLM after failure of standard SCT. Among them, 20 (47 %) patients underwent HAI combined with SCT (Group A) and 23 historical control patients who had received SCT with or without targeted agent treatment (Group B).

Results

The two groups had similar characteristics. Compared with SCT alone, HAI combined with SCT prolonged survival (median 19.8 vs. 9.0 months; P = 0.045). Median hepatic progression-free survival was significantly longer for HAI combined with SCT vs. SCT alone (median 8.1 vs. 4.7 months; P = 0.027), as were response rates (25 and 0 %; P = 0.038) and progression-free survival (median 5.7 vs. 3.0 months; P = 0.02). Three patients (15 %) achieved conversion to potentially curative surgery. Grade 3/4 toxicities for Group A and Group B were neutropenia (5 and 8.7 %, respectively), anemia (5 and 0 %, respectively), and hyperbilirubinemia (0 and 4.3 %, respectively). Other complications were mostly grade 1 or 2.

Conclusions

HAI combined with SCT treatment can improve overall survival compared with SCT alone in highly advanced CLM refractory to intravenous chemotherapy.

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Titel: Hepatic arterial infusion plus systemic chemotherapy as third-line or later treatment in colorectal liver metastases
verfasst von: W.-G. Qiang
L.-R. Shi
X.-D. Li
Q.-Q. Wu
J.-M. Zhao
L.-J. Chen
Y. Yang
J. Wu
M. Ji
C.-P. Wu
Publikationsdatum: 01.11.2015
Verlag: Springer Milan
Erschienen in: Clinical and Translational Oncology / Ausgabe 11/2015
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-015-1317-8

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Hepatic arterial infusion plus systemic chemotherapy as third-line or later treatment in colorectal liver metastases