Erschienen in:
15.11.2016 | Case Report
Hepatitis A virus genotype IA-infected patient with marked elevation of aspartate aminotransferase levels
verfasst von:
Yoshifumi Miura, Tatsuo Kanda, Shin Yasui, Koji Takahashi, Yuki Haga, Reina Sasaki, Masato Nakamura, Shuang Wu, Shingo Nakamoto, Makoto Arai, Tsutomu Nishizawa, Hiroaki Okamoto, Osamu Yokosuka
Erschienen in:
Clinical Journal of Gastroenterology
|
Ausgabe 1/2017
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Abstract
We describe a case of acute liver failure (ALF) without hepatic encephalopathy with marked elevation of aminotransferase due to hepatitis A, according to the revised Japanese criteria of ALF. This liver biopsy of the patient showed compatible to acute viral hepatitis and she immediately recovered without intensive care. She had no comorbid disorders. Of interest, phylogenetic tree analysis using almost complete genomes of hepatitis A virus (HAV) demonstrated that the HAV isolate from her belonged to the HAV subgenotype IA strain and was similar to the HAJFF-Kan12 strain (99% nucleotide identity) or FH1 strain (98% nucleotide identity), which is associated with severe or fulminant hepatitis A. Careful interpretation of the association between HAV genome variations and severity of hepatitis A is needed and the mechanism of the severe hepatitis should be explored.