nach oben

Documenta Ophthalmologica

Erschienen in:

01.02.2010 | Review Article

Hereditary influences in oxygen-induced retinopathy in the rat

verfasst von: Peter van Wijngaarden, Helen M. Brereton, Douglas J. Coster, Keryn A. Williams

Erschienen in: Documenta Ophthalmologica | Ausgabe 1/2010

Einloggen, um Zugang zu erhalten

Abstract

Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have identified marked and consistent variations in susceptibility to OIR amongst different inbred rat strains and provide strong evidence for a genetic determinant of susceptibility to OIR. Furthermore, we have characterised differences in retinal angiogenic factor gene expression amongst different inbred rat strains exposed to cyclic hyperoxia. A key determinant of susceptibility to OIR appears to be the extent to which pro-angiogenic factor genes, such as vascular endothelial growth factor and erythropoietin, are expressed during the period of hyperoxic exposure. Those strains in which expression is relatively well maintained are less susceptible to retinopathy than are those in which expression is reduced. In addition, we identify an association between ocular pigmentation and OIR susceptibility.

Gilbert C, Awan H (2003) Blindness in children. BMJ 327:760–761CrossRefPubMed

Early Treatment for Retinopathy of Prematurity Cooperative Group (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121:1684–1694CrossRefPubMed

Madan A, Penn JS (2003) Animal models of oxygen-induced retinopathy. Front Biosci 8:1030–1043CrossRef

van Wijngaarden P, Coster DJ, Brereton HM, Gibbins IL, Williams KA (2005) Strain- dependent differences in oxygen-induced retinopathy in the inbred rat. Invest Ophthalmol Vis Sci 46:1445–1452CrossRefPubMed

van Wijngaarden P, Brereton HM, Coster DJ, Williams KA (2007) Genetic influences on susceptibility to oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 48:1761–1766CrossRefPubMed

van Wijngaarden P, Brereton HM, Gibbins IL, Coster DJ, Williams KA (2007) Kinetics of strain-dependent differential gene expression in oxygen-induced retinopathy in the rat. Exp Eye Res 85:508–517CrossRefPubMed

Flynn J (1992) The premature retina: a model for the in vivo study of molecular genetics? Eye 6:161–165PubMed

Wheatley CM, Dickinson JL, Mackey DA, Craig JE, Sale MM (2002) Retinopathy of prematurity: recent advances in our understanding. Br J Ophthalmol 86:696–700CrossRefPubMed

Holmström G, van Wijngaarden P, Coster DJ, Williams KA (2007) Genetic susceptibility to retinopathy of prematurity—the evidence from clinical and experimental animal studies. Br J Ophthalmol 91:1704–1708CrossRefPubMed

10.

Bizzarro MJ, Hussain N, Jonsson B et al (2006) Genetic susceptibility to retinopathy of prematurity. Pediatrics 118:1858–1863CrossRefPubMed

11.

Ng YK, Fielder AR, Shaw DE, Levene MI (1988) Epidemiology of retinopathy of prematurity. Lancet 2(8622):1235–1238CrossRefPubMed

12.

Schaffer DB, Palmer EA, Plotsky D, The Cryotherapy for Retinopathy of Prematurity Cooperative Group et al (1993) Prognostic factors in the natural course of retinopathy of prematurity. Ophthalmology 100:30–37

13.

Saunders RA, Donahue ML, Christmann LM, The Cryotherapy for Retinopathy of Prematurity Cooperative Group et al (1997) Racial variation in retinopathy of prematurity. Arch Ophthalmol 115:604–608PubMed

14.

Yang MB, Donovan EF, Wagge JR (2006) Race, gender and clinical risk index for babies (CRIB) score as predictors of severe retinopathy of prematurity. J AAPOS 10:253–261CrossRefPubMed

15.

Pass D, Freeth G (1993) The Rat. ANZCCART Fact Sheet. Available via http://www.adelaide.edu.au/ANZCCART/publications/FS_TheRat.pdf. Accessed 19 Jan 2009

16.

Clause BT (1998) The Wistar Institute archives: rats (not mice) and history. Mendel Newsletter. Available via http://www.amphilsoc.org/library/mendel/1998.htm. Accessed 19 Jan 2009

17.

Baker HJ, Lindsey JR, Weisbroth SH (1979) The laboratory rat. Vol 1 Biology and diseases. Academic Press, New York

18.

Festing MFW (1998) Inbred strains of rats. Mouse Genome Informatics index of major rat strains. Available via http://www.informatics.jax.org/external/festing/rat/STRAINS.shtml. Accessed 19 Jan 2009

19.

Michaelson IC (1948) The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases. Trans Ophthalmol Soc UK 68:137–181

20.

Ashton N, Ward B, Serpell G (1954) Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol 38:397–432CrossRefPubMed

21.

Chan-Ling T, Stone J (1993) Retinopathy of prematurity: its origins in the architecture of the retina. Prog Ret Res 12:155–178CrossRef

22.

Zhang W, Ito Y, Berlin E, Roberts R, Berkowitz BA (2003) Role of hypoxia during normal retinal vessel development and in experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci 44:3119–3123CrossRefPubMed

23.

Stone J, Itin A, Alon T et al (1995) Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci 15:4738–4747PubMed

24.

Reynaud X, Dorey CK (1994) Extraretinal neovascularization induced by hypoxic episodes in the neonatal rat. Invest Ophthalmol Vis Sci 35:3169–3177PubMed

25.

Smith LEH (2008) Through the eyes of a child: understanding retinopathy through ROP. The Friedenwald Lecture. Invest Ophthalmol Vis Sci 49:5177–5182CrossRefPubMed

26.

Penn JS, Tolman BL, Henry MM (1994) Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization. Invest Ophthalmol Vis Sci 35:3429–3435PubMed

27.

Ventresca MR, Gonder JR, Tanswell AK (1990) Oxygen-induced proliferative retinopathy in the newborn rat. Can J Ophthalmol 25:186–189PubMed

28.

Penn JS, Tolman BL, Lowery LA (1993) Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Invest Ophthalmol Vis Sci 34:576–585PubMed

29.

Penn JS, Henry MM, Wall PT, Tolman BL (1995) The range of PaO₂ variation determines the severity of oxygen-induced retinopathy in newborn rats. Invest Ophthalmol Vis Sci 36:2063–2070PubMed

30.

Cunningham S, McColm JR, Wade J, Sedowofia K, McIntosh N, Fleck B (2000) A novel model of retinopathy of prematurity simulating preterm oxygen variability in the rat. Invest Ophthalmol Vis Sci 41:4275–4280PubMed

31.

Weinberger B, Laskin DL, Heck DE, Laskin JD (2002) Oxygen toxicity in premature infants. Toxicol Appl Pharmacol 181:60–67CrossRefPubMed

32.

Leduc M, Kermorvant-Duchemin E, Checchin D et al (2006) Hypercapnia- and trans-arachidonic acid-induced retinal microvascular degeneration: implications in the genesis of retinopathy of prematurity. Semin Perinatol 30:129–138CrossRefPubMed

33.

Owens WC, Owens EU (1994) Retrolental fibroplasia in premature infants. Am J Ophthalmol 32:1–21

34.

The Committee for the Classification of Retinopathy of Prematurity (1984) An international classification of retinopathy of prematurity. Arch Ophthalmol 102:1130–1134

35.

International Committee for the Classification of Retinopathy of Prematurity (2005) The international classification of retinopathy of prematurity revisited. Arch Ophthalmol 123:991–999CrossRef

36.

Aiello LP, Pierce EA, Foley ED et al (1995) Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 92:10457–10461CrossRefPubMed

37.

Roberts R, Zhang W, Ito Y, Berkowitz BA (2003) Spatial pattern and temporal evolution of retinal oxygenation response in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 44:5315–5320CrossRefPubMed

38.

Wilkinson-Berka JL, Tan G, Jaworski K, Miller AG (2009) Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology. Circ Res 104:124–133CrossRefPubMed

39.

Sato T, Kusaka S, Hashida N, Saishin Y, Fujikado T, Tano Y (2009) Comprehensive gene-expression profile in murine oxygen-induced retinopathy. Br J Ophthalmol 93:96–103CrossRefPubMed

40.

Dammann O, Brinkhaus MJ, Bartels DB et al (2009) Immaturity, perinatal inflammation, and retinopathy of prematurity: a multi-hit hypothesis. Early Hum Dev 85:325–329CrossRefPubMed

41.

Hayes CE, Goldstein IJ (1974) An alpha-d-galactosyl-binding lectin from Bandeiraea simplicifolia seeds. Isolation by affinity chromatography and characterization. J Biol Chem 249:1904–1914PubMed

42.

van Wijngaarden P, Brereton HM, Coster DJ, Williams KA (2007) Stability of housekeeping gene expression in the rat retina during exposure to cyclic hyperoxia. Mol Vis 13:1508–1515PubMed

43.

Gao G, Li Y, Zhang D, Gee S, Crosson C, Ma J (2001) Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett 489:270–276CrossRefPubMed

44.

Gao G, Li Y, Fant J, Crosson CE, Becerra SP, Ma JX (2002) Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium-derived factor in Brown Norway and Sprague-Dawley rats contributing to different susceptibilities to retinal neovascularization. Diabetes 51:1218–1225CrossRefPubMed

45.

Kim SY, Mocanu C, Mcleod DS et al (2003) Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid. Exp Eye Res 77:433–445CrossRefPubMed

46.

Ohno-Matsui K, Morita I, Tombran-Tink J et al (2001) Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol 189:323–333CrossRefPubMed

47.

Kitzmann A, Leske D, Chen Y, Kendall A, Lanier W, Holmes J (2002) Incidence and severity of neovascularization in oxygen- and metabolic acidosis-induced retinopathy depend on rat source. Curr Eye Res 25:215–220CrossRefPubMed

48.

Floyd BN, Leske DA, Wren SM, Mookadam M, Fautsch MP, Holmes JM (2005) Differences between rat strains in models of retinopathy of prematurity. Mol Vis 11:524–530PubMed

49.

Zhang SX, Ma JX, Sima J et al (2005) Genetic difference in susceptibility to the blood–retina barrier breakdown in diabetes and oxygen-induced retinopathy. Am J Pathol 166:313–321PubMed

50.

Sears JE, Hoppe G, Ebrahem Q, Anand-Apte B (2008) Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc Natl Acad Sci USA 105:19898–19903CrossRefPubMed

Titel: Hereditary influences in oxygen-induced retinopathy in the rat
verfasst von: Peter van Wijngaarden
Helen M. Brereton
Douglas J. Coster
Keryn A. Williams
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: Documenta Ophthalmologica / Ausgabe 1/2010
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-009-9196-3

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Hereditary influences in oxygen-induced retinopathy in the rat

Abstract

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2010

Editorial for special issue: rat models of ROP

Oxygen supply and consumption in the retina: implications for studies of retinopathy of prematurity

The development of the rat model of retinopathy of prematurity

ISCEV standard for clinical visual evoked potentials (2009 update)

Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy

Evidence for a critical role of panretinal pathophysiology in experimental ROP

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde