Background
Methods
Data source
Question 1: “Have you ever been diagnosed with shingles (herpes zoster) by a physician?”Question 2: “Have you been diagnosed with shingles (herpes zoster) by a physician in the last twelve months?”And if question 1 was answered with yes:Question 3: “At what age (in which year) have you been diagnosed with shingles (herpes zoster)?”Question 4: “Have you ever been diagnosed by a physician with postherpetic neuralgia as a complication of shingles (herpes zoster)?”
First author (year) | Data collection year | Data source | HZ incidence rate per 1000 PY (95%-CI) |
---|---|---|---|
Ultsch (2013) [2] | 2004 to 2009 | SHI AOK Hesse/KV Hesse | 5.8 (5.6 to 5.9) |
Ultsch (2011) [23] | 2007 to 2008 | ASHIP databasea | 9.6 (9.6 to 9.6)b |
Hillebrand (2014) [24] | 2005 to 2009 | GePaRDc | 6.0 (5.9 to 6.0) |
Statistical analysis
Results
Baseline characteristics of the study population
Variables | Male (n = 2145) n (%) | Female (n = 2606) n (%) | Total (n = 4751) n (%) |
---|---|---|---|
Age-group in years | |||
20 to 29 | 170 (7.9) | 233 (8.9) | 403 (8.5) |
30 to 39 | 212 (9.9) | 249 (9.6) | 461 (9.7) |
40 to 49 | 481 (22.4) | 601 (23.1) | 1082 (22.8) |
50 to 59 | 542 (25.3) | 709 (27.2) | 1251 (26.3) |
60 to 69 | 740 (34.5) | 814 (31.2) | 1554 (32.7) |
Median age in years (IQR) | 53 (44 to 62) | 52 (43 to 61) | 53 (43 to 62) |
Education levela | |||
High | 1067 (49.7) | 1143 (43.9) | 2210 (46.5) |
Intermediate | 300 (14.0) | 596 (22.9) | 896 (18.9) |
Low | 717 (33.4) | 785 (30.1) | 1502 (31.6) |
Without school-leaving certificate | 29 (1.4) | 35 (1.3) | 64 (1.3) |
Missing data | 32 (1.5) | 47 (1.8) | 79 (1.7) |
Herpes zoster cases | 209 (9.7) | 330 (12.7) | 539 (11.3) |
Crude annual herpes zoster incidence rate
Cumulative incidence of herpes zoster
Age-group (in years) | Hazard Ratio (95%-CI) for female vs male sexa | p-value |
---|---|---|
20 to 29 | 1.05 (0.80 to 1.38) | 0.727 |
30 to 39 | 1.13 (0.74 to 1.72) | 0.569 |
40 to 49 | 2.05 (1.36 to 3.13) | < 0.001 |
50 to 59 | 1.62 (1.04 to 2.51) | 0.031 |
60 to 69 | 1.96 (1.05 to 3.66) | 0.035 |