Background
Methods
Tissue samples
Real-time reverse transcription-polymerase chain reaction analysis
Data analysis
Results
Patient characteristics
Number of patients (%) | |
---|---|
Total patients | 125 |
Age in years (median) | 35-83 (62.0) |
≤60 | 50 (40.0) |
≥60 | 75 (60.0) |
Sex | |
Male | 82 (65.6) |
Female | 43 (34.4) |
Positive nodes | |
absent | 55 (44.0) |
present | 70 (56.0) |
Stage | |
I | 20 (16.0) |
II | 31 (24.8) |
III | 55 (44.0) |
IV | 19 (15.2) |
Primary lesion | |
Right colon | 24 (19.2) |
Left colon | 45 (36.0) |
Rectum | 56(44.8) |
Histology | |
Well differentiated | 16 (12.8) |
Moderately differentiated | 100 (80.0) |
Poorly differentiated | 5 (4.0) |
Mucinous | 4 (3.2) |
Blood/lymphatic vessel invasion | |
Absent | 109 (87.2) |
Present | 16 (12.8) |
Surgery | |
Curative | 113 (90.4) |
Palliative | 12 (9.6) |
Factors associated with KLF4 expression in normal and tumor tissues
Variable | tKLF4 | P value* | nKLF4 | P value* | ||
---|---|---|---|---|---|---|
<2150 | ≥2150 | <7969 | ≥7969 | |||
Age (years) | ||||||
<60 | 36 (72.0%) | 14 (28.0%) | 42 (84.0%) | 8 (16.0%) | ||
≥60 | 44 (58.7%) | 31 (41.3%) | 0.128 | 51 (68.0%) | 24 (32.0%) | 0.045 |
Gender
| ||||||
Male | 49 (60.5%) | 32 (39.5%) | 59 (72.8%) | 22 (27.2%) | ||
Female | 31 (70.5%) | 13 (29.5%) | 0.268 | 34 (77.3%) | 10 (22.7%) | 0.588 |
Stage
| ||||||
I-III | 72 (67.9%) | 34 (32.1%) | 79 (74.5%) | 27 (25.5%) | ||
IV | 8 (42.1%) | 11 (57.9%) | 0.031 | 14 (73.7%) | 5 (26.3%) | 0.938 |
LN metastasis
| ||||||
+ | 46 (64.8%) | 25 (35.2%) | 55 (77.5%) | 16 (22.5%) | ||
− | 34 (63.0%) | 20 (37.0%) | 0.833 | 38 (70.4%) | 16 (29.6%) | 0.368 |
Anatomic distribution
| ||||||
Right | 14 (58.3%) | 10 (41.7%) | 22 (91.7%) | 2 (8.3%) | ||
Left | 33 (73.3%) | 12 (26.7%) | 32 (71.1%) | 13 (28.9%) | ||
Rectum | 33 (58.9%) | 23 (41.1%) | 0.264 | 39 (69.9%) | 17 (30.4%) | 0.096 |
Variable | Estimated coefficient | Estimated standard error | Wald X2 statistics | P value* | Estimated odds ratio | Confidence interval for odds ratio |
---|---|---|---|---|---|---|
Stage (I-III, IV) | 0.108 | 0.611 | 0.031 | 0.860 | 1.114 | (0.336-3.685) |
Age in years (<60, ≥60) | 1.087 | 0.482 | 5.076 | 0.024 | 2.965 | (1.152-7.631) |
Gender (M, F) | −0.314 | 0.471 | 0.443 | 0.505 | 0.731 | (0.290-1.840) |
LN metastasis (+,−) | 0.649 | 0.459 | 1.994 | 0.158 | 1.913 | (0.778-4.705) |
Anatomic distribution (right, left colon) | 1.644 | 0.826 | 3.964 | 0.046 | 5.178 | (1.026-26.135) |
Anatomic distribution (right colon, rectum) | 1.801 | 0.815 | 4.880 | 0.027 | 6.054 | (1.225-29.916) |