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01.08.2013 | Nephrology - Original Paper

High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients

verfasst von: Tanja Antunovic, Aleksandra Stefanovic, Marina Ratkovic, Branka Gledovic, Najdana Gligorovic-Barhanovic, Dragica Bozovic, Jasmina Ivanisevic, Milica Prostran, Marina Stojanov

Erschienen in: International Urology and Nephrology | Ausgabe 4/2013

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Abstract

Purpose

We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients.

Methods

SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method.

Results

sUA among survivors (112.1 ± 13.82 μmol/L) was significantly lower than in deceased (160.8 ± 16.81 μmol/L, p < 0.001), while SOD was higher in survivors (31.8 ± 6.61 kU/L) than among deceased (20.2 ± 3.03, p < 0.05). Kaplan–Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (≥127.11 μmol/L, p < 0.001), and for SOD in the lowest tertile (≤23.83 kU/L, p < 0.05).

Conclusion

Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.

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Titel: High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
verfasst von: Tanja Antunovic
Aleksandra Stefanovic
Marina Ratkovic
Branka Gledovic
Najdana Gligorovic-Barhanovic
Dragica Bozovic
Jasmina Ivanisevic
Milica Prostran
Marina Stojanov
Publikationsdatum: 01.08.2013
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 4/2013
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-012-0233-x

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Abstract

Purpose

Methods

Results

Conclusion

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