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2021 | OriginalPaper | Buchkapitel

19. Hintergrund/diagnostische Grundkonzepte

verfasst von : Uwe Pleyer, Gerhild Wildner, Ulrike Kaufmann, Stephan Thurau, Sylvia Metzner

Erschienen in: Entzündliche Augenerkrankungen

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Intraokulare Entzündungen stellen in Europa und weltweit eine wesentliche Ursache schwerwiegender Sehschädigungen dar. In der Altersgruppe der 20- bis 40-Jährigen stehen sie als Erblindungsursache zusammen mit der diabetischen Retinopathie an erster Stelle (◘ Tab. 19.1). Es können alle Altersgruppen betroffen sein, allerdings treten die meisten Erkrankungen im Alter zwischen 20 und 40 Jahren auf. Rezidive werden bei etwa 30 % aller akuten Entzündungen beobachtet. Etwa 50 % aller Patienten weisen eine Grunderkrankung oder assoziierte Merkmale (z. B. HLA-B27 Antigen) auf. Hinweise auf die Pathogenese und das differentialdiagnostische Vorgehen gehen aus den ► Abschnitten 19.1.1.1 und 19.1.3 hervor.

Klinisch ermittelt und angelehnt an die Klassifikation der International Uveitis Study Group.

Ang M, Cheung G, Vania M, Chen J, Yang H, Li J, Chee SP (2012) Aqueous cytokine and chemokine analysis in uveitis associated with tuberculosis. Mol Vis 18:565–573PubMedPubMedCentral

Barisani-Asenbauer T, Maca SM, Mejdoubi L, Emminger W, Machold K, Auer H (2012) Uveitis – a rare disease often associated with systemic diseases and infections – a systematic review of 2619 patients. Orphanet J Rare Dis 29(7):57

Borrelli E, Sarraf D, Freund KB, Sadda SR (2018) OCT angiography and evaluation of the choroid and choroidal vascular disorders. Prog Retin Eye Res 67:30–55

Chu CJ, Gardner PJ, Copland DA (2016) Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model. Dis Model Mech 9:473–481PubMedPubMedCentral

Coomes SM, Pelly VS, Wilson M (2013) Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? Open Biol 3:120157PubMedPubMedCentral

Daas L, Seitz B, Pleyer U (2017) Fuchs uveitis. Ophthalmologe 114(5):481–492PubMed

Davis JL (2012) Diagnostic dilemmas in retinitis and Endophthalmitis. Eye (Lond) 26(2):194–201

Davis JL, Madow B, Cornett J, Stratton R, Hess D, Porciatti V, Feuer WJ (2010) Scale for photographic grading of vitreous haze in uveitis. Am J Ophthalmol 150:637–641PubMedPubMedCentral

Denniston AK, Keane PA, Srivastava SK (2017) Biomarkers and surrogate endpoints in uveitis: the impact of quantitative imaging. Invest Ophthalmol Vis Sci 58(6) BIO131–BIO140

deSmet MD, Taylor SR, Bodaghi B, Pleyer U, Murray PI, Miserocchi E et al (2011) Understanding uveitis: the impact of research on visual outcomes. Prog Retin Eye Res 30:452–470

Dhoot DS, Martin DF, Srivastava SK (2011) Pediatric infectious posterior uveitis. Int Ophthalmol Clin 51(1):113–128PubMed

Diedrichs-Möhring M, Kaufmann U, Wildner G (2018) The immunopathogenesis of chronic and relapsing autoimmune uveitis – lessons from experimental rat models. Prog Retin Eye Res 65:107–126

Doan T, Wilson MR, Crawford ED, Chow ED, Khan LM, Knopp KA, O’Donovan BD, Xia D, Hacker JK, Stewart JM, Gonzales JA, Acharya NR, JL DR (2016) Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens. Genome Med 25(8):90

Garweg JG, Tappeiner C (2011) Differential diagnosis in infectious posterior uveitis. Klin Monatsbl Augenheilkd 228(4):268–272PubMed

Gillmann K, El Ameen A, Massy R, Fabro F, Gasc A, Herbort CP Jr (2019) Assessment of measurement methods of posterior inflammation in stromal choroiditis: the value of quantitative outcome measures versus the presently qualitatively based paradigm. Int Ophthalmol 39:1567–1574PubMed

González-López JJ, García-Aparicio ÁM, Sánchez-Ponce (2016) Development and validation of a Bayesian network for the differential diagnosis of anterior uveitis. Eye (Lond) 30:865–872

Grewal DS, O'Sullivan ML, Kron M, Jaffe GJ (2017) Association of disorganization of retinal inner layers with visual acuity in eyes with uveitic cystoid macular edema. Am J Ophthalmol 177:116–125PubMed

Grumet P, Kodjikian L, de Parisot et al (2018) ULISSE group. Contribution of diagnostic tests for the etiological assessment of uveitis, data from the ULISSE study (Uveitis: Clinical and medicoeconomic evaluation of a standardized strategy of the etiological diagnosis). Autoimmun Rev 17(4):331–343PubMed

Gundlach E, Temmesfeld-Wollbrück B, Pleyer U (2017) Okulare Sarkoidose. Diagnose und Therapie. Ophthalmologe 114(9):865–876PubMed

Haasnoot AJW, Kuiper JJW, de Boer JH (2019) Predicting uveitis in juvenile idiopathic arthritis: from biomarkers to clinical practice. Expert Rev Clin Immunol 15:657–666PubMed

Heiligenhaus A, Thurau S, Hennig M, Grajewski RS, Wildner G (2010) Anti-inflammatory treatment of uveitis with biologicals: new treatment options that reflect pathogenic knowledge of the disease. Graefe’s Arch. Clin Exp Ophthalmol 248:1531–1551

Heiligenhaus A, Minden K, Föll D, Pleyer U (2015) Uveitis in juvenile idiopathic arthritis. Dtsch Arztebl Int 112(6):92–100PubMedPubMedCentral

Herbort CP, LeHoang P, Guex-Crosier Y (1998) Schematic interpretation of indocyanine green angiography in posterior uveitis using a standard angiographic protocol. Ophthalmology 105(3):432–440PubMed

Hogan MH, Kimura SJ, Thygeson P (1959) Signs and symptoms of uveitis: I. Anterior uveitis. Am J Ophthalmol 47:155–170PubMed

http://www.dog.org/wp-content/uploads/2009/09/LL-Uveitis-anterior-2011-11-30-Endversion.pdf. Zugegriffen am 01.08.2020. Leitlinie Nr. 14a Uveitis anterior

https://augeninfo.de/leit/leit24a.pdf. Zugegriffen am 01.08.2020

https://augeninfo.de/leit/leit24b.pdf. Zugegriffen am 01.08.2020

https://www.rki.de/DE/Content/Infekt/EpidBull/Merkblaetter/Ratgeber_Tuberkulose.html. Zugegriffen am 01.08.2020

https://www.who.int/tb/features_archive/igra_factsheet_oct2011.pdf. Zugegriffen am 01.08.2020

Ishibashi T, Sakimoto S, Shiraki N et al (2019) Association between disorganization of retinal inner layers and visual acuity after proliferative diabetic retinopathy surgery. Sci Rep 9:–155, 12230 47

Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of Uveitis Nomenclature (SUN) working group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140:509–516

Jaffe GJ, Foster CS, Pavesio CE et al (2019) Effect of an injectable fluocinolone acetonide insert on recurrence rates in chronic noninfectious uveitis affecting the posterior segment: twelve-months results. Ophthalmology 126:601–610PubMed

Jakob E et al (2009) Uveitis subtypes in a german interdisciplinary uveitis center – analysis of 1916 patients. J Rheumatol 36:127–136

Kitazawa K, Sotozono C, Koizumi N, Nagata K, Inatomi T, Sasaki H, Kinoshita S (2017) Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed disposable pipette. Br J Ophthalmol 101:548–550PubMed

Lenglinger M, Pohlmann D, Pleyer U (2020) Anteriore virale Uveitis. Klinik, diagnostisches Vorgehen und Behandlungsoptionen. Ophthalmologe 117:83–92PubMed

Liu X, Diedrichs-Möhring M, Wildner G (2017) The role of IFN-alpha in experimental and clinical uveitis. Ocul Immunol Inflamm. https://doi.org/10.1080/09273948.2017.1298822

Ma L, Jakobiec FA, Dryja TP, A Review of Next-Generation Sequencing (NGS) (2019) Applications to the diagnosis of ocular infectious diseases. Semin Ophthalmol 34(4):223–231PubMed

Madow B, Galor A, Feuer WJ, Altaweel MM, Davis JL (2011) Validation of a photographic vitreous haze grading technique for clinical trials in uveitis. Am J Ophthalmol 152(2):170–176PubMedPubMedCentral

Maenz M, Schlüter D, Liesenfeld O, Schares G, Gross U, Pleyer U (2014) Ocular toxoplasmosis past, present and new aspects of an old disease. Prog Retin Eye Res 39:77–106PubMed

Miserocchi E, Ferreri AJM, Giuffrè C, Cangi MG, Francaviglia I, Calimeri T, Ponzoni M, Pecciarini L, Bandello FM, Modorati GM (2019) MYD88 L265P mutation detection in the aqueous humor of patients with vitreoretinal lymphoma. Retina 39:679–684PubMed

Montesano G, Way CM, Ometto G et al (2018) Optimizing OCT acquisition parameters for assessments of vitreous haze for application in uveitis. Sci Rep 8:1648PubMedPubMedCentral

Murphy K, Weaver C (2018) Janeway immunologie, 9. Aufl. Springer Spektrum, Berlin

Naumann GOH Pathologie des Auges. 12. Auflage. Springer-Verlag, Berlin, Heidelberg, New York; S 88–155

Nussenblatt RB, Palestine AG, Chan CC, Roberge F (1985) Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology 92:467–471PubMed

Pathanapitoon K, Dodds EM, Cunningham ET Jr, Rothova A (2017) Clinical Spectrum of HLA-B27-associated Ocular Inflammation. Ocul Immunol Inflamm 25(4):569–576PubMed

Petrushkin H, Sethi C, Potter J et al (2020) Developing a pathway for the diagnosis and management of ocular tuberculosis. The pan-LOndon Ocular tuberculosis Pathway-LOOP. Eye (Lond) 34(5):805–808.

Pichi F, Sarraf D, Arepalli S, Lowder CY, Cunningham ET Jr, Neri P, Albini TA, Gupta V, Baynes K (2017 Jul) Srivastava SK (2017) The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. Prog Retin Eye Res 59:178–201PubMed

Pichis F, Invernizzi A, Tucker WR, Munk MR (2019a) Optical coherence tomography diagnostic signs in posterior uveitis. Prog Retin Eye Res. https://doi.org/10.1016/j.preteyeres.2019.100797. [Epub ahead of print]

Pichi F, Roberts P, Neri P (2019b) The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: a review of the literature. J Ophthalmic Inflamm Infect 9:18PubMedPubMedCentral

Pleyer U, Ruokonen P (2010) Kammerwasseranalyse in der Diagnostik intraokularer Entzündungen. Klin Monatsbl Augenheilkd 227:953–960PubMed

Pohlmann D, Schlickeiser S, Metzner S, Lenglinger M, Winterhalter S, Pleyer U (2018) Different composition of intraocular immune mediators in Posner-Schlossman-Syndrome and Fuchs' Uveitis. PLoS One 26(13):e0199301

Pohlmann D, Pleyer U, Joussen AM, Winterhalter S (2019a) Optical coherence tomography angiography in comparison with other multimodal imaging techniques in punctate inner choroidopathy. Br J Ophthalmol 103:60–66PubMed

Pohlmann D, Winterhalter S, Pleyer U (2019b) „White-dot-Syndrome“ Grundlagen, Diagnostik und Therapie. Ophthalmologe 116:1235–1256PubMed

Reznicek L, Kernt M, Seidensticker F, Stumpf C, Thurau S, Kampik A, Neubauer A (2012) Autofluorescence in posterior uveitis. Ophthalmology 119(8):1712–1713PubMed

Rosenbaum JT et al (2008) Uveitis secondary to bacterial products. Ophthalmic Res 40:165–168PubMed

Rothova A et al (1996) Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol 80:332–336PubMedPubMedCentral

Schroeder K, Tschopp J (2010) The Inflammasomes. Cell 140:821–832

Sen HN, Sangave AA, Goldstein DA, Suhler EB, Cunningham D, Vitale S, Nussenblatt RB (2011) A standardized grading system for scleritis. Ophthalmology 118:768–771PubMed

Sève P, Cacoub P, Bodaghi B et al (2017) Uveitis: Diagnostic work-up. A literature review and recommendations from an expert committee. Autoimmun Rev 16(12):1254–1264PubMed

Sheehan NJ (2010) HLA-B27: what’s new? Rheumatology 49:621–631PubMed

de Sousa LA, Leitner J, Grabmeier-Pfistershammer K, Steinberger P (2018) Not all immune checkpoints are created equal. Front Immunol 31. https://doi.org/10.3389/fimmu.2018.01909

Stein-Streilein J, Lucas K (2011) A current understanding of ocular immune privilege. Curr Immunol Rev 7:336–343

Thieme C, Schlickeiser S, Metzner S, Dames C, Pleyer U (2019) Immune mediator profile in aqueous humor differs in patients with primary acquired ocular toxoplasmosis and recurrent acute ocular toxoplasmosis. Mediat Inflamm:9356728

Thurau S, Pleyer U (2016) Differenzialdiagnose der anterioren intraokularen Entzündung. Ophthalmologe 113(10):879–892PubMed

Thurau S, Wildner GG (2010) Chorioiditis. Ophthalmologe 107:79–93PubMed

Tranos P, Karasavvidou EM, Gkorou O, Pavesio C (2019) Optical coherence tomography angiography in uveitis. J Ophthalmic Inflamm Infect 9(1):21PubMedPubMedCentral

Tugal-Tutkun I, Herbort CP, Khairallah M (2010) Angiography Scoring for Uveitis Working Group (ASUWOG). Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol 30:539–552PubMed

Tyndall J (1869) On the blue colour of the sky, the polarization of skylight, and on the polarization of light by cloudy matter generally. Philos Mag J Sci 37:384–404

Wang JC, Miller JB (2019) Optical coherence tomography angiography: review of current technical aspects and applications in chorioretinal disease. Semin Ophthalmol 34:211–217PubMed

Wendling D (2012) Uveitis in seronegative arthritis. Curr Rheumatol Rep 14(5):402–408PubMed

Werner RN, Steinhorst NI, Nast A, Pleyer U (2017) Diagnostik und Management des Herpes zoster ophthalmicus. Ophthalmologe 114(10):959–972PubMed

Wildner G (2019) Are rats more human than mice? Immunobiology 224:172–176PubMed

Wildner G, Diedrichs-Möhring M (2004) Autoimmune uveitis and antigenic mimicry of environmental antigens. Autoimmun Rev 3:383–387PubMed

Wildner G, Kaufmann U (2013) What causes relapses of autoimmune diseases? The etiological role of autoreactive T cells. Autoimmun Rev 12(11):1070–1075. https://doi.org/10.1016/j.bbr.2011.03.031CrossRefPubMed

Willermain F, Rosenbaum JT, Bodaghi B, Rosenzweig HL, Childers S, Behrend T, Wildner G, Dick A (2012) Interplay between innate and adaptive immunity in the development of non-infectious uveitis. Prog Retin Eye Res 31:182–194PubMed

Zaidi AA, Ying GS, Daniel E, Gangaputra S, Rosenbaum JT, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Kempen JH (2010) systemic immunosuppressive therapy for eye diseases cohort study. hypopyon in patients with uveitis. Ophthalmology 117(2):366–372PubMed

Zamecki KJ, Jabs DA (2010) HLA typing in uveitis: use and misuse. Am J Ophthalmol 149(2):189–193PubMed

Titel: Hintergrund/diagnostische Grundkonzepte
verfasst von: Uwe Pleyer
Gerhild Wildner
Ulrike Kaufmann
Stephan Thurau
Sylvia Metzner
Verlag: Springer Berlin Heidelberg
Buch: Entzündliche Augenerkrankungen
Print ISBN: 978-3-662-60398-7

Electronic ISBN: 978-3-662-60399-4

Copyright-Jahr: 2021
DOI: https://doi.org/10.1007/978-3-662-60399-4_19

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19. Hintergrund/diagnostische Grundkonzepte

Zusammenfassung

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Zusammenfassung

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Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde