HIV-induced immune activation - pathogenesis and clinical relevance. Summary of a workshop organised by the German AIDs Society (DAIG e.v.) and the ICH Hamburg, Hamburg, Germany, November 22, 2008

1.

Amendola A, Gougeon ML, Poccia F, Bondurand A, Fesus L, Piacentini M: Induction of "tissue" transglutaminase in HIV pathogenesis: evidence for high rate of apoptosis of CD4+ T lymphocytes and accessory cells in lymphoid tissues. Proc Natl Acad Sci USA 1996,93(20):11057–11062. 10.1073/pnas.93.20.11057PubMedCentralPubMed

2.

Pantaleo G, Fauci AS: Immunopathogenesis of HIV infection. Annu Rev Microbiol 1996, 50: 825–854. 10.1146/annurev.micro.50.1.825PubMed

3.

Andersson J, Fehninger TE, Patterson BK, Pottage J, Agnoli M, Jones P, et al.: Early reduction of immune activation in lymphoid tissue following highly active HIV therapy. Aids 1998,12(11):F123-F129. 10.1097/00002030-199811000-00004PubMed

4.

Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, et al.: Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006,12(12):1365–1371.PubMed

5.

Hazenberg MD, Stuart JW, Otto SA, Borleffs JC, Boucher CA, de Boer RJ, et al.: T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000,95(1):249–255.PubMed

6.

Blomback M, Kjellman H, Schulman S, Egberg N, Bottiger B, Wiechel B: Immunoglobulin levels in haemophiliacs at HIV seroconversion and during follow up. Infection 1987,15(4):248–252. 10.1007/BF01644125PubMed

7.

McGowan JP, Shah SS, Small CB, Klein RS, Schnipper SM, Chang CJ, et al.: Relationship of serum immunoglobulin and IgG subclass levels to race, ethnicity and behavioral characteristics in HIV infection. Med Sci Monit 2006,12(1):CR11-CR16.PubMed

8.

Carbone J, Sarmiento E, Rodriguez-Molina JJ, Gil J, Fernandez-Cruz E: Immunoglobulin levels and prediction of progression to AIDS in HIV-infected injection drug users. AIDS Patient Care STDS 2004,18(12):685–686. 10.1089/apc.2004.18.685PubMed

9.

Cavallin F, Traldi A, di GR, De BE, Davoli G, Gajo G, et al.: Predictor of the rate of CD4 lymphocyte loss in HIV-1 seropositive asymptomatic hemophiliacs by in vitro immunoglobulin synthesis. Clin Immunol Immunopathol 1996,81(3):224–228. 10.1006/clin.1996.0182PubMed

10.

Sweet SP, Rahman D, Challacombe SJ: Serum and saliva immunoglobulin A concentrations show an inverse relationship in HIV infection and AIDS. Aids 1995,9(11):1288–1289. 10.1097/00002030-199511000-00014PubMed

11.

Mares M, Sartori MT, Zerbinati P, Girolami A: The importance of serial immunoglobulin evaluations in HIV-sero positive haemophiliacs. Haematologia (Budap) 1993,25(4):271–276.

12.

Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, et al.: CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004,200(6):749–759. 10.1084/jem.20040874PubMedCentralPubMed

13.

Mehandru S, Poles MA, Tenner-Racz K, Manuelli V, Jean-Pierre P, Lopez P, et al.: Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection. J Virol 2007,81(2):599–612. 10.1128/JVI.01739-06PubMedCentralPubMed

14.

Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C, et al.: Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004,200(6):761–770. 10.1084/jem.20041196PubMedCentralPubMed

15.

Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, Lopez P, et al.: Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection. PLoS Med 2006,3(12):e484. 10.1371/journal.pmed.0030484PubMedCentralPubMed

16.

Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, et al.: Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol 2007,179(5):3026–3034.PubMedCentralPubMed

17.

Pandrea IV, Gautam R, Ribeiro RM, Brenchley JM, Butler IF, Pattison M, et al.: Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence. J Immunol 2007,179(5):3035–3046.PubMedCentralPubMed

18.

Hahn BH, Shaw GM, De Cock KM, Sharp PM: AIDS as a zoonosis: scientific and public health implications. Science 2000,287(5453):607–614. 10.1126/science.287.5453.607PubMed

19.

Gao F, Bailes E, Robertson DL, Chen Y, Rodenburg CM, Michael SF, et al.: Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 1999,397(6718):436–441. 10.1038/17130PubMed

20.

Santiago ML, Rodenburg CM, Kamenya S, Bibollet-Ruche F, Gao F, Bailes E, et al.: SIVcpz in wild chimpanzees. Science 2002,295(5554):465. 10.1126/science.295.5554.465PubMed

21.

Wertheim JO, Worobey M: Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2. PLoS Comput Biol 2009,5(5):e1000377. 10.1371/journal.pcbi.1000377PubMedCentralPubMed

22.

Gao F, Yue L, White AT, Pappas PG, Barchue J, Hanson AP, et al.: Human infection by genetically diverse SIVSM-related HIV-2 in west Africa. Nature 1992,358(6386):495–499. 10.1038/358495a0PubMed

23.

Keele BF, Jones JH, Terio KA, Estes JD, Rudicell RS, Wilson ML, et al.: Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature 2009,460(7254):515–519. 10.1038/nature08200PubMedCentralPubMed

24.

Pandrea I, Silvestri G, Apetrei C: AIDS in african nonhuman primate hosts of SIVs: a new paradigm of SIV infection. Curr HIV Res 2009,7(1):57–72. 10.2174/157016209787048456PubMed

25.

Kirchhoff F, Schindler M, Specht A, Arhel N, Munch J: Role of Nef in primate lentiviral immunopathogenesis. Cell Mol Life Sci 2008,65(17):2621–2636. 10.1007/s00018-008-8094-2PubMed

26.

Munch J, Schindler M, Wildum S, Rucker E, Bailer N, Knoop V, et al.: Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication. J Virol 2005,79(16):10547–10560. 10.1128/JVI.79.16.10547-10560.2005PubMedCentralPubMed

27.

Collins KL, Chen BK, Kalams SA, Walker BD, Baltimore D: HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 1998,391(6665):397–401. 10.1038/34929PubMed

28.

Fortin JF, Barat C, Beausejour Y, Barbeau B, Tremblay MJ: Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NFkappaB, and AP-1 induction. J Biol Chem 2004,279(38):39520–39531. 10.1074/jbc.M407477200PubMed

29.

Schindler M, Munch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, et al.: Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006,125(6):1055–1067. 10.1016/j.cell.2006.04.033PubMed

30.

Paiardini M, Pandrea I, Apetrei C, Silvestri G: Lessons learned from the natural hosts of HIV-related viruses. Annu Rev Med 2009, 60: 485–495. 10.1146/annurev.med.60.041807.123753PubMed

31.

Rockstroh J: Besonderheiten im Verlauf der HIV-Infektion bei Hämophilen. Shaker-Verlag; 1999.

32.

Giorgi JV, Huktin LE, McKeating JA, Johnson TD, Owens B, Jacobson LP, et al.: Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden of Virus Chemo kine Coreceptor Usage. J Infect Dis 1999, 179: 859–870. 10.1086/314660PubMed

33.

Holm M, Pettersen FO, Kvale D: PD-1 predicts CD4 loss rate in chronic HIV-1 infection better than HIV RNA and CD38 but not in cryopreserved samples. Curr HIV Res 2008,6(1):49–58. 10.2174/157016208783571955PubMed

34.

Steel A, John L, Shamji MH, Henderson DC, Gotch FM, Gazzard BG, et al.: CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. HIV Med 2008,9(2):118–125. 10.1111/j.1468-1293.2007.00528.xPubMed

35.

Wilson CM, Ellenberg JH, Douglas SD, Moscicki AB, Holland CA: CD8+CD38+ T cells but not HIV type 1 RNA viral load predict CD4+ T cell loss in a predominantly minority female HIV+ adolescent population. AIDS Res Hum Retroviruses 2004,20(3):263–269. 10.1089/088922204322996482PubMed

36.

Perfetto SP, Malone JD, Hawkes C, McCrary G, August B, Zhou S, et al.: CD38 expression on cryopreserved CD8+ T cells predicts HIV disease progression. Cytometry 1998,33(2):133–137. 10.1002/(SICI)1097-0320(19981001)33:2<133::AID-CYTO7>3.0.CO;2-KPubMed

37.

Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, Giorgi JV: Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997,16(2):83–92. 10.1097/00042560-199710010-00003PubMed

38.

Giorgi JV, Liu Z, Hultin LE, Cumberland WG, Hennessey K, Detels R: Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 1993,6(8):904–912.PubMed

39.

Kestens L, Vanham G, Gigase P, Young G, Hannet I, Vanlangendonck F, et al.: Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection. Aids 1992,6(8):793–797. 10.1097/00002030-199208000-00004PubMed

40.

Muller P, Engelstadter M, Werner A, Braner J, Staszewski S, Miller V, et al.: Increased serum and mRNA levels of RANTES associated with elevated levels of activated CD8+CD38+ T cells in HIV-1 infected individuals. Intervirology 1997,40(4):263–270. 10.1159/000150556PubMed

41.

Ndhlovu LC, Loo CP, Spotts G, Nixon DF, Hecht FM: FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. J Leukoc Biol 2008,83(2):254–262.PubMed

42.

Steel A, Cox AE, Shamji MH, John L, Nelson M, Henderson DC, et al.: HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation. Antivir Ther 2007,12(6):971–975.PubMed

43.

el-Sadr WM, Lundgren JD, Neaton JD, Gordin F, Abrams D, Arduino RC, et al.: CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med 2006,355(22):2283–2296.PubMed

44.

Korner C, Kramer B, Schulte D, Coenen M, Mauss S, Fatkenheuer G, et al.: Effects of HCV co-infection on apoptosis of CD4+ T cells in HIV-positive patients. Clin Sci (Lond) 2009.

45.

Sankaran S, George MD, Reay E, Guadalupe M, Flamm J, Prindiville T, et al.: Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. J Virol 2008,82(1):538–545. 10.1128/JVI.01449-07PubMedCentralPubMed

46.

Chang JJ, Altfeld M: TLR-mediated immune activation in HIV. Blood 2009,113(2):269–270.PubMed

47.

Hall JG: The functional anatomy of lymph nodes. In Lymph Node Biopsy Interpretation. Edited by: Stansfeld AG. Edinburgh London Melbourne New York: Churchill Living-stone; 1985:1–25.

48.

Tenner-Racz K, Racz P: Follicular dendritic cells initiate and maintain infection of the germinal centers by human immunodeficiency virus. Curr Top Microbiol Immunol 1995, 201: 141–159. 10.1007/978-3-642-79603-6_9PubMed

49.

Grouard G, Durand I, Filgueira L, Banchereau J, Liu YJ: Dendritic cells capable of stimulating T cells in germinal centres. Nature 1996,384(6607):364–367. 10.1038/384364a0PubMed

50.

Kim CH, Rott L, Kunkel EJ, Genovese MC, Andrew DP, Wu L, et al.: Rules of chemokine receptor association with T cell polarization in vivo. J Clin Invest 2001,108(9):1331–1339.PubMedCentralPubMed

51.

Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, et al.: Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000,192(11):1545–1552. 10.1084/jem.192.11.1545PubMedCentralPubMed

52.

Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B: CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000,192(11):1553–1562. 10.1084/jem.192.11.1553PubMedCentralPubMed

53.

Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, Rolph MS, et al.: T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004,173(1):68–78.PubMed

54.

Arnold CN, Campbell DJ, Lipp M, Butcher EC: The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 2007,37(1):100–109. 10.1002/eji.200636486PubMed

55.

Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC: Unique gene expression program of human germinal center T helper cells. Blood 2004,104(7):1952–1960. 10.1182/blood-2004-03-1206PubMed

56.

Ansel KM, Heyzer-Williams LJ, Ngo VN, Heyzer-Williams MG, Cyster JG: In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 1999,190(8):1123–1134. 10.1084/jem.190.8.1123PubMedCentralPubMed

57.

Mazzucchelli L, Blaser A, Kappeler A, Scharli P, Laissue JA, Baggiolini M, et al.: BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J Clin Invest 1999,104(10):R49-R54. 10.1172/JCI7830PubMedCentralPubMed

58.

Amft N, Curnow SJ, Scheel-Toellner D, Devadas A, Oates J, Crocker J, et al.: Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjogren's syndrome. Arthritis Rheum 2001,44(11):2633–2641. 10.1002/1529-0131(200111)44:11<2633::AID-ART443>3.0.CO;2-9PubMed

59.

Carlsen HS, Baekkevold ES, Johansen FE, Haraldsen G, Brandtzaeg P: B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue. Gut 2002,51(3):364–371. 10.1136/gut.51.3.364PubMedCentralPubMed

60.

Burkle A, Niedermeier M, Schmitt-Graff A, Wierda WG, Keating MJ, Burger JA: Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Blood 2007,110(9):3316–3325. 10.1182/blood-2007-05-089409PubMed

61.

Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT: A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 1998,391(6669):799–803. 10.1038/35876PubMed

62.

Cagigi A, Mowafi F, Phuong Dang LV, Tenner-Racz K, Atlas A, Grutzmeier S, et al.: Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood 2008,112(12):4401–4410. 10.1182/blood-2008-02-140426PubMed

63.

Allen SJ, Crown SE, Handel TM: Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol 2007, 25: 787–820. 10.1146/annurev.immunol.24.021605.090529PubMed

64.

Bachmann MF, Kopf M, Marsland BJ: Chemokines: more than just road signs. Nat Rev Immunol 2006,6(2):159–164. 10.1038/nri1776PubMed

65.

Ahuja SK, Kulkarni H, Catano G, Agan BK, Camargo JF, He W, et al.: CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1 infected individuals. Nat Med 2008,14(4):413–420. 10.1038/nm1741PubMedCentralPubMed

66.

Kuller LH, Tracy R, Belloso W, de WS, Drummond F, Lane HC, et al.: Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008,5(10):e203. 10.1371/journal.pmed.0050203PubMedCentralPubMed

67.

Kovacs JA, Lempicki RA, Sidorov IA, Adelsberger JW, Her-pin B, Metcalf JA, et al.: Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. J Exp Med 2001,194(12):1731–1741. 10.1084/jem.194.12.1731PubMedCentralPubMed

68.

Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, et al.: Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival. N Engl J Med 2009.

69.

Zolopa A, Andersen J, Komarow L, Sanchez A, Suckow C, Sanne I, et al.: Immediate vs Deferred ART in the Setting of Acute AIDS-related Opportunistic Infection: Final Results of a Randomized Strategy Trial, ACTG A5164. 15th Con Retrovir Opportun Infect 2008 Boston, USA abstract #142 2008. Ref Type: Abstract Ref Type: Abstract

70.

Lawn SD, Myer L, Bekker LG, Wood R: Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa. Aids 2007,21(3):335–341. 10.1097/QAD.0b013e328011efacPubMed

71.

Saraceni V, King BS, Pacheco AGF, Golub JE, Cavalcante SC, Moulton LH, et al.: Tuberculosis, HAART use and survival in the THRio Cohort, Rio de Janeiro, Brazil. XVII International AIDS Conference, 3–8 August 2008, Mexico City abstract #MOAB0305 2008. Ref Type: Abstract Ref Type: Abstract

72.

Sabin CA, Worm SW, Weber R, Reiss P, El-Sadr W, Dabis F, et al.: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet 2008,371(9622):1417–1426.PubMed

73.

Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients Aids 2008,22(14):F17-F24.

74.

Cutrell A, Hernandez J, Yeo J, Brothers C, Burkle W, Spreen W: Is abacavir (ABC)-containing combination antiretroviral therapy (CART) associated with myocardial infarction (MI)? No association identified in pooled summary of 54 clinical trials. XVII International AIDS Conference, 3–8 August 2008, Mexico City abstract #WEAB0106 2008. Ref Type: Abstract Ref Type: Abstract

75.

McComsey GA, Smith KY, Patel P, Bellos NC, Sloan L, Lackey P, et al.: Similar Reductions in Markers of Inflammation and Endothelial Activation after Initiation of Abacavir/Lamivudine (ABC/3TC) or Tenofovir/Emtricitabine (TDF/FTC) in the HEAT Study. 16th Conf Retrovir Opportun Infect, Montreal, Canada abstract #732 2009. Ref Type: Abstract Ref Type: Abstract

76.

Martin AM, Nolan D, Gaudieri S, Almeida CA, Nolan R, James I, et al.: Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci USA 2004,101(12):4180–4185. 10.1073/pnas.0307067101PubMedCentralPubMed

77.

Triant VA, Lee H, Hadigan C, Grinspoon SK: Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab 2007,92(7):2506–2512. 10.1210/jc.2006-2190PubMedCentralPubMed

78.

Libby P, Theroux P: Pathophysiology of coronary artery disease. Circulation 2005,111(25):3481–3488. 10.1161/CIRCULATIONAHA.105.537878PubMed

79.

Hurlimann D, Weber R, Enseleit F, Luscher TF: HIV infection, antiretroviral therapy, and endothelium. Herz 2005,30(6):472–480. 10.1007/s00059-005-2740-3PubMed

80.

Friis-Moller N, Reiss P, Sabin CA, Weber R, Monforte A, El-Sadr W, et al.: Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007,356(17):1723–1735.PubMed

81.

Charakida M, Donald AE, Green H, Storry C, Clapson M, Caslake M, et al.: Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation 2005,112(1):103–109. 10.1161/CIRCULATIONAHA.104.517144PubMed

82.

Coll B, Parra S, onso-Villaverde C, Aragones G, Montero M, Camps J, et al.: The role of immunity and inflammation in the progression of atherosclerosis in patients with HIV infection. Stroke 2007,38(9):2477–2484. 10.1161/STROKEAHA.106.479030PubMed

83.

Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, et al.: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008,359(21):2195–2207. 10.1056/NEJMoa0807646PubMed

84.

Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW: Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 1988,318(12):727–732. 10.1056/NEJM198803243181202PubMed

85.

Quasney MW, Zhang Q, Sargent S, Mynatt M, Glass J, McArthur J: Increased frequency of the tumor necrosis factor-alpha-308 A allele in adults with human immunodeficiency virus dementia. Ann Neurol 2001,50(2):157–162. 10.1002/ana.1284PubMed

86.

Witkin SS, Linhares IM, Gerber S, Caetano ME, Segurado AC: Interleukin-1 receptor antagonist gene polymorphism and circulating levels of human immunodeficiency virus type 1 RNA in Brazilian women. J Virol 2001,75(13):6242–6244. 10.1128/JVI.75.13.6242-6244.2001PubMedCentralPubMed

87.

Do H, Vasilescu A, Diop G, Hirtzig T, Coulonges C, Labib T, et al.: Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort. Immunogenetics 2006,58(2–3):89–98. 10.1007/s00251-005-0072-3PubMed

88.

Price P, James I, Fernandez S, French MA: Alleles of the gene encoding IL-1alpha may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral therapy. Aids 2004,18(11):1495–1501. 10.1097/01.aids.0000131352.06784.c6PubMed

89.

Lori F, Maserati R, Lisziewicz J, Minoli L: Immune Reconstitution and Control of HIV. Conference Report. June 5–6, 2003; Stresa, Italy 2004, 170–82.

90.

Song H, Nakayama EE, Likanonsakul S, Wasi C, Iwamoto A, Shioda T: A three-base-deletion polymorphism in the upstream non-coding region of human interleukin 7 (IL-7) gene could enhance levels of IL-7 expression. Int J Immunogenet 2007,34(2):107–113. 10.1111/j.1744-313X.2007.00658.xPubMed

91.

Price P, Mathiot N, Krueger R, Stone S, Keane NM, French MA: Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy. J Clin Virol 2001,22(3):279–287. 10.1016/S1386-6532(01)00200-1PubMed

92.

Haas DW, Geraghty DE, Andersen J, Mar J, Motsinger AA, D'Aquila RT, et al.: Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study. J Infect Dis 2006,194(8):1098–1107. 10.1086/507313PubMed

93.

Engels EA, Pfeiffer RM, Goedert JJ, Virgo P, McNeel TS, Scoppa SM, et al.: Trends in cancer risk among people with AIDS in the United States 1980–2002. Aids 2006,20(12):1645–1654. 10.1097/01.aids.0000238411.75324.59PubMed

94.

Wyen C, Fätkenheuer G, Oette M, Plettenberg A, Rockstroh J, van Lunzen J, et al.: Treatment of AIDS-related Lymphoma: Rituximab May Be Beneficial Even in Severely Immunosuppressed Patients. 15th Con Retrovir Opportun Infect 2008 Boston, USA abstract #1026 2008. Ref Type: Abstract Ref Type: Abstract

95.

Gloghini A, Carbone A: Why would the incidence of HIV-associated Hodgkin lymphoma increase in the setting of improved immunity? Int J Cancer 2007,120(12):2753–2754. 10.1002/ijc.22650PubMed

96.

Bonnet F, Burty C, Lewden C, Costagliola D, May T, Bouteloup V, et al.: Changes in cancer mortality among HIV-infected patients: the Mortalite 2005 Survey. Clin Infect Dis 2009,48(5):633–639. 10.1086/596766PubMed

97.

d'Arminio MA, Sabin CA, Phillips A, Sterne J, May M, Justice A, et al.: The changing incidence of AIDS events in patients receiving highly active antiretroviral therapy. Arch Intern Med 2005,165(4):416–423.

98.

Silverberg MJ, Neuhaus J, Bower M, Gey D, Hatzakis A, Henry K, et al.: Risk of cancers during interrupted antiretroviral therapy in the SMART study. Aids 2007,21(14):1957–1963. 10.1097/QAD.0b013e3282ed6338PubMed

99.

Monforte A, Abrams D, Pradier C, Weber R, Reiss P, Bonnet F, et al.: HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies. Aids 2008,22(16):2143–2153.PubMed

100.

Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM: Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 2007,370(9581):59–67. 10.1016/S0140-6736(07)61050-2PubMed

101.

Grulich AE, Wan X, Law MG, Milliken ST, Lewis CR, Garsia RJ, et al.: B-cell stimulation and prolonged immune deficiency are risk factors for non-Hodgkin's lymphoma in people with AIDS. Aids 2000,14(2):133–140. 10.1097/00002030-200001280-00008PubMed

102.

Breen EC, Fatahi S, Epeldegui M, Boscardin WJ, Detels R, Martinez-Maza O: Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma. Tumour Biol 2006,27(4):187–194. 10.1159/000093022PubMed

103.

Epeldegui M, Breen EC, Hung YP, Boscardin WJ, Detels R, Martinez-Maza O: Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. Aids 2007,21(17):2265–2270. 10.1097/QAD.0b013e3282ef9f59PubMed

104.

Zoufaly A, Stellbrink H-J, an der Heiden M, Kollan C, Hoffmann C, van Lunzen J, et al.: Cumulative HIV viremia during highly active antiretroviral therapy is a strong predictor for AIDS-related lymphoma. Journal Of Infectious Diseases 2009, in press. Ref Type: Abstract Ref Type: Abstract

105.

Oksenhendler E, Boulanger E, Galicier L, Du MQ, Dupin N, Diss TC, et al.: High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood 2002,99(7):2331–2336. 10.1182/blood.V99.7.2331PubMed

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