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12.07.2022

HIV-related drivers of sexual compulsivity and sexuality in sexual minority men who use methamphetamine

verfasst von: Hema R. Kondur, Tae K. Lee, Roger McIntosh, Hetta Gouse, Robert Paul, Christian Grov, Dietmar Fuchs, Walter Gómez, Samantha E. Dilworth, Torsten B. Neilands, Adam W. Carrico

Erschienen in: Journal of NeuroVirology | Ausgabe 3/2022

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Abstract

Although co-occurring methamphetamine (meth) use and HIV amplify the risk for neuropsychiatric comorbidities, the underlying neuroimmune mechanisms are not well characterized. We examined whether a detectable viral load and dysregulated metabolism of amino acid precursors for neurotransmitters predicted subsequent levels of sexual compulsivity and sexual sensation seeking. This 15-month longitudinal study enrolled 110 sexual minority men (SMM) living with HIV who had biologically confirmed meth use (i.e., reactive urine or hair toxicology results). Peripheral venous blood samples collected at baseline, 6 months, 12 months, and 15 months were used to measure a detectable viral load (> 40 copies/mL), the kynurenine/tryptophan (K/T) ratio, and the phenylalanine/tyrosine (P/T) ratio. The K/T and P/T ratios index dysregulated serotonin and catecholamine (e.g., dopamine) synthesis, respectively. In a cross-lagged panel model, a detectable viral load at 6 months predicted greater sexual compulsivity at 12 months after adjusting for prior levels of sexual compulsivity and recent stimulant use (β = 0.26, p = 0.046). A greater P/T ratio at baseline predicted decreased sexual sensation seeking at 6 months (β = − 0.25, p = 0.004) after adjusting for baseline sexual sensation seeking and recent stimulant use. Taken together, HIV replication and dysregulated catecholamine synthesis could potentiate sexual compulsivity while decreasing sexual pleasure in SMM who use meth.

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Titel: HIV-related drivers of sexual compulsivity and sexuality in sexual minority men who use methamphetamine
verfasst von: Hema R. Kondur
Tae K. Lee
Roger McIntosh
Hetta Gouse
Robert Paul
Christian Grov
Dietmar Fuchs
Walter Gómez
Samantha E. Dilworth
Torsten B. Neilands
Adam W. Carrico
Publikationsdatum: 12.07.2022
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 3/2022
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-022-01085-0

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