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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.01.2007 | Original article

Homocysteine levels are associated with the results of ¹²³I-metaiodobenzylguanidine myocardial scintigraphy in type 2 diabetic patients

verfasst von: Futoshi Anan, Hidetoshi Yonemochi, Takayuki Masaki, Naohiko Takahashi, Mikiko Nakagawa, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimatsu

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2007

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Abstract

Purpose

Elevated total plasma homocysteine (tHcy) levels and cardiovascular autonomic dysfunction are associated with a high mortality in type 2 diabetic patients. We tested the hypothesis that hyperhomocysteinemia is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients not receiving insulin treatment.

Methods

The study group consisted of 17 type 2 diabetic patients with high tHcy levels (>15 mmol/l, age 58±5 years, high tHcy group). The control group consisted of 23 age-matched type 2 diabetic patients with normal tHcy levels (≤15 mmol/l, age 58±9 years, normal tHcy group). Cardiovascular autonomic function was assessed by baroreflex sensitivity, heart rate variability, plasma norepinephrine concentrations, and cardiac ¹²³I-metaiodobenzylguanidine (MIBG) scintigraphy.

Results

Early and delayed ¹²³I-MIBG myocardial uptake values were lower (p<0.005 and p<0.01, respectively) and the percent washout rate of ¹²³I-MIBG was higher (p<0.001) in the high tHcy group than in the normal tHcy group. The fasting plasma insulin concentrations (p<0.0001) and the homeostasis model assessment (HOMA) index values (p<0.0001) were higher in the high tHcy group than in the normal tHcy group. Multiple regression analysis revealed that the level of tHcy was independently predicted by the HOMA index values and the myocardial uptake of ¹²³I-MIBG at the delayed phase.

Conclusion

Our results demonstrate that high levels of tHcy are associated with depressed cardiovascular autonomic function and insulin resistance in patients with type 2 diabetes mellitus.

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Titel: Homocysteine levels are associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in type 2 diabetic patients
verfasst von: Futoshi Anan
Hidetoshi Yonemochi
Takayuki Masaki
Naohiko Takahashi
Mikiko Nakagawa
Nobuoki Eshima
Tetsunori Saikawa
Hironobu Yoshimatsu
Publikationsdatum: 01.01.2007
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2007
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-006-0200-9

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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