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Erschienen in: Current Psychiatry Reports 7/2016

01.07.2016 | Eating Disorders (C Grilo, Section Editor)

Hormonal Factors and Disturbances in Eating Disorders

verfasst von: Kristen M. Culbert, Sarah E. Racine, Kelly L. Klump

Erschienen in: Current Psychiatry Reports | Ausgabe 7/2016

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Abstract

This review summarizes the current state of the literature regarding hormonal correlates of, and etiologic influences on, eating pathology. Several hormones (e.g., ghrelin, CCK, GLP-1, PYY, leptin, oxytocin, cortisol) are disrupted during the ill state of eating disorders and likely contribute to the maintenance of core symptoms (e.g., dietary restriction, binge eating) and/or co-occurring features (e.g., mood symptoms, attentional biases). Some of these hormones (e.g., ghrelin, cortisol) may also be related to eating pathology via links with psychological stress. Despite these effects, the role of hormonal factors in the etiology of eating disorders remains unknown. The strongest evidence for etiologic effects has emerged for ovarian hormones, as changes in ovarian hormones predict changes in phenotypic and genetic influences on disordered eating. Future studies would benefit from utilizing etiologically informative designs (e.g., high risk, behavioral genetic) and continuing to explore factors (e.g., psychological, neural responsivity) that may impact hormonal influences on eating pathology.
Literatur
1.
Zurück zum Zitat American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.
2.•
Zurück zum Zitat Holsen LM, Lawson EA, Christensen K, Klibanski A, Goldstein JM. Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa. Psychiatry Res Neuroimaging. 2014;223:94–103. This fMRI study was the first to show that following exposure to food cues, women with active AN or weight-restored AN exhibit abnormalities in the association between circulating levels of ghrelin and neural activity in food motivation regions.CrossRefPubMed Holsen LM, Lawson EA, Christensen K, Klibanski A, Goldstein JM. Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa. Psychiatry Res Neuroimaging. 2014;223:94–103. This fMRI study was the first to show that following exposure to food cues, women with active AN or weight-restored AN exhibit abnormalities in the association between circulating levels of ghrelin and neural activity in food motivation regions.CrossRefPubMed
3.
Zurück zum Zitat Kojima S, Nakahara T, Nagai N, Muranaga T, Tanaka M, Yasuhara D, et al. Altered ghrelin and peptide YY responses to meals in bulimia nervosa. Clin Endocrinol (Oxf). 2005;62:74–8.CrossRef Kojima S, Nakahara T, Nagai N, Muranaga T, Tanaka M, Yasuhara D, et al. Altered ghrelin and peptide YY responses to meals in bulimia nervosa. Clin Endocrinol (Oxf). 2005;62:74–8.CrossRef
4.
Zurück zum Zitat Monteleone P, Fabrazzo M, Tortorella A, Martiadis V, Serritella C, Maj M. Circulating ghrelin is decreased in non-obese and obese women with binge eating disorder as well as in obese non-binge eating women, but not in patients with bulimia nervosa. Psychoneuroendocrinology. 2005;30:243–50.CrossRefPubMed Monteleone P, Fabrazzo M, Tortorella A, Martiadis V, Serritella C, Maj M. Circulating ghrelin is decreased in non-obese and obese women with binge eating disorder as well as in obese non-binge eating women, but not in patients with bulimia nervosa. Psychoneuroendocrinology. 2005;30:243–50.CrossRefPubMed
5.
Zurück zum Zitat Sedlackova D, Kopeckova J, Papezova H, Hainer V, Kvasnickova H, Hill M, et al. Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa. Nutr Metab (Lond). 2012;9:1186.CrossRef Sedlackova D, Kopeckova J, Papezova H, Hainer V, Kvasnickova H, Hill M, et al. Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa. Nutr Metab (Lond). 2012;9:1186.CrossRef
6.
Zurück zum Zitat Devlin MJ, Kissileff HR, Zimmerli EJ, Samuels F, Chen BE, Brown AJ, et al. Gastric emptying and symptoms of bulimia nervosa: effect of a prokinetic agent. Physiol Behav. 2012;106:238–42.CrossRefPubMedPubMedCentral Devlin MJ, Kissileff HR, Zimmerli EJ, Samuels F, Chen BE, Brown AJ, et al. Gastric emptying and symptoms of bulimia nervosa: effect of a prokinetic agent. Physiol Behav. 2012;106:238–42.CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Sedlackova D, Kopeckova J, Papezova H, Vybiral S, Kvasnickova H, Hill M, et al. Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast. Physiol Res. 2011;60:165–73.PubMed Sedlackova D, Kopeckova J, Papezova H, Vybiral S, Kvasnickova H, Hill M, et al. Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast. Physiol Res. 2011;60:165–73.PubMed
8.
Zurück zum Zitat Bello NT, Coughlin JW, Redgrave GW, Moran TH, Guarda AS. Oral sensory and cephalic hormonal responses to fat and non-fat liquids in bulimia nervosa. Physiol Behav. 2010;99:611–7.CrossRefPubMedPubMedCentral Bello NT, Coughlin JW, Redgrave GW, Moran TH, Guarda AS. Oral sensory and cephalic hormonal responses to fat and non-fat liquids in bulimia nervosa. Physiol Behav. 2010;99:611–7.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Monteleone P, Serritella C, Scognamiglio P, Maj M. Enhanced ghrelin secretion in the cephalic phase of food ingestion in women with bulimia nervosa. Psychoneuroendocrinology. 2010;35:284–8.CrossRefPubMed Monteleone P, Serritella C, Scognamiglio P, Maj M. Enhanced ghrelin secretion in the cephalic phase of food ingestion in women with bulimia nervosa. Psychoneuroendocrinology. 2010;35:284–8.CrossRefPubMed
10.
Zurück zum Zitat Monteleone P, Serritella C, Martiadis V, Scognamiglio P, Maj M. Plasma obestatin, ghrelin, and ghrelin/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa. J Clin Endocrinol Metab. 2008;93:4418–21.CrossRefPubMed Monteleone P, Serritella C, Martiadis V, Scognamiglio P, Maj M. Plasma obestatin, ghrelin, and ghrelin/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa. J Clin Endocrinol Metab. 2008;93:4418–21.CrossRefPubMed
11.
Zurück zum Zitat Gluck ME, Yahav E, Hashim SA, Geliebter A. Ghrelin levels after a cold pressor stress test in obese women with binge eating disorder. Psychosom Med. 2014;76:74–9.CrossRefPubMed Gluck ME, Yahav E, Hashim SA, Geliebter A. Ghrelin levels after a cold pressor stress test in obese women with binge eating disorder. Psychosom Med. 2014;76:74–9.CrossRefPubMed
12.
Zurück zum Zitat Buss J, Havel PJ, Epel E, Lin J, Blackburn E, Daubenmier J. Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite. 2014;76:84–94.CrossRefPubMedPubMedCentral Buss J, Havel PJ, Epel E, Lin J, Blackburn E, Daubenmier J. Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite. 2014;76:84–94.CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Adamo KB, Wilson SL, Ferraro ZM, Hadjiyannakis S, Doucet É, Goldfield GS. Appetite sensations, appetite signaling proteins, and glucose in obese adolescents with subclinical binge eating disorder. ISRN Obes. 2014;2014:1–7.CrossRef Adamo KB, Wilson SL, Ferraro ZM, Hadjiyannakis S, Doucet É, Goldfield GS. Appetite sensations, appetite signaling proteins, and glucose in obese adolescents with subclinical binge eating disorder. ISRN Obes. 2014;2014:1–7.CrossRef
14.
Zurück zum Zitat Raspopow K, Abizaid A, Matheson K, Anisman H. Psychosocial stressor effects on cortisol and ghrelin in emotional and non-emotional eaters: influence of anger and shame. Horm Behav. 2010;58:677–84.CrossRefPubMed Raspopow K, Abizaid A, Matheson K, Anisman H. Psychosocial stressor effects on cortisol and ghrelin in emotional and non-emotional eaters: influence of anger and shame. Horm Behav. 2010;58:677–84.CrossRefPubMed
15.
Zurück zum Zitat Raspopow K, Abizaid A, Matheson K, Anisman H. Anticipation of a psychosocial stressor differentially influences ghrelin, cortisol and food intake among emotional and non-emotional eaters. Appetite. 2014;74:35–43.CrossRefPubMed Raspopow K, Abizaid A, Matheson K, Anisman H. Anticipation of a psychosocial stressor differentially influences ghrelin, cortisol and food intake among emotional and non-emotional eaters. Appetite. 2014;74:35–43.CrossRefPubMed
16.•
Zurück zum Zitat Myhre R, Kratz M, Goldberg J, Polivy J, Melhorn S, Buchwald D, et al. A twin study of differences in the response of plasma ghrelin to a milkshake preload in restrained eaters. Physiol Behav. 2014;129:50–6. This study was novel in that it was the first to utilize a discordant twin design to explore associations between eating pathology (i.e., restrained eating) and levels of appetite-regulating hormones (i.e., ghrelin). Results indicated that only the twin with restrained eating exhibited higher ghrelin concentrations across meals, suggesting that ghrelin disturbances may be a consequence of restrained eating as opposed to an underlying genetic predisposition.CrossRefPubMedPubMedCentral Myhre R, Kratz M, Goldberg J, Polivy J, Melhorn S, Buchwald D, et al. A twin study of differences in the response of plasma ghrelin to a milkshake preload in restrained eaters. Physiol Behav. 2014;129:50–6. This study was novel in that it was the first to utilize a discordant twin design to explore associations between eating pathology (i.e., restrained eating) and levels of appetite-regulating hormones (i.e., ghrelin). Results indicated that only the twin with restrained eating exhibited higher ghrelin concentrations across meals, suggesting that ghrelin disturbances may be a consequence of restrained eating as opposed to an underlying genetic predisposition.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Monteleone P, Tortorella A, Scognamiglio P, Serino I, Monteleone AM, Maj M. The acute salivary ghrelin response to a psychosocial stress is enhanced in symptomatic patients with bulimia nervosa: a pilot study. Neuropsychobiology. 2012;66:230–6.CrossRefPubMed Monteleone P, Tortorella A, Scognamiglio P, Serino I, Monteleone AM, Maj M. The acute salivary ghrelin response to a psychosocial stress is enhanced in symptomatic patients with bulimia nervosa: a pilot study. Neuropsychobiology. 2012;66:230–6.CrossRefPubMed
18.
Zurück zum Zitat Hilterscheid E, Laessle R. Stress-induced release of GUT peptides in young women classified as restrained or unrestrained eaters. Eat Weight Disord. 2015;20:435–9.CrossRefPubMed Hilterscheid E, Laessle R. Stress-induced release of GUT peptides in young women classified as restrained or unrestrained eaters. Eat Weight Disord. 2015;20:435–9.CrossRefPubMed
19.
Zurück zum Zitat Geliebter A, Carnell S, Gluck ME. Cortisol and ghrelin concentrations following a cold pressor stress test in overweight individuals with and without night eating. Int J Obes. 2013;37:1104–8.CrossRef Geliebter A, Carnell S, Gluck ME. Cortisol and ghrelin concentrations following a cold pressor stress test in overweight individuals with and without night eating. Int J Obes. 2013;37:1104–8.CrossRef
20.
Zurück zum Zitat Rouach V, Bloch M, Rosenberg N, Gilad S, Limor R, Stern N, et al. The acute ghrelin response to a psychological stress challenge does not predict the post-stress urge to eat. Psychoneuroendocrinology. 2007;32:693–702.CrossRefPubMed Rouach V, Bloch M, Rosenberg N, Gilad S, Limor R, Stern N, et al. The acute ghrelin response to a psychological stress challenge does not predict the post-stress urge to eat. Psychoneuroendocrinology. 2007;32:693–702.CrossRefPubMed
21.
Zurück zum Zitat Cuntz U, Enck P, Frühauf E, Lehnert P, Riepl RL, Fichter MM, et al. Cholecystokinin revisited: CCK and the hunger trap in anorexia nervosa. PLoS ONE. 2013;8:e54457.CrossRefPubMedPubMedCentral Cuntz U, Enck P, Frühauf E, Lehnert P, Riepl RL, Fichter MM, et al. Cholecystokinin revisited: CCK and the hunger trap in anorexia nervosa. PLoS ONE. 2013;8:e54457.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Keel PK, Wolfe BE, Liddle RA, De Young KP, Jimerson DC. Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa. Arch Gen Psychiatry. 2007;64:1058–66.CrossRefPubMed Keel PK, Wolfe BE, Liddle RA, De Young KP, Jimerson DC. Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa. Arch Gen Psychiatry. 2007;64:1058–66.CrossRefPubMed
23.••
Zurück zum Zitat Rigamonti AE, Sartorio A, Scognamiglio P, Bini S, Monteleone AM, Mastromo D, et al. Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa. Neuropsychobiology. 2014;70:228–34. Recognizing that bile salts have modulatory effects on the postprandial secretion of CCK and PYY, particularly in response to a high fat meal, this study experimentally controlled for bile salt concentrations in patients with BN and controls. Impairments in CCK function in patients with BN were only detected when the confounding effects of bile salts were pharmacologically controlled for.CrossRefPubMed Rigamonti AE, Sartorio A, Scognamiglio P, Bini S, Monteleone AM, Mastromo D, et al. Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa. Neuropsychobiology. 2014;70:228–34. Recognizing that bile salts have modulatory effects on the postprandial secretion of CCK and PYY, particularly in response to a high fat meal, this study experimentally controlled for bile salt concentrations in patients with BN and controls. Impairments in CCK function in patients with BN were only detected when the confounding effects of bile salts were pharmacologically controlled for.CrossRefPubMed
25.
Zurück zum Zitat Dossat AM, Bodell LP, Williams DL, Eckel LA, Keel PK. Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa: purging disorder and bulimia nervosa. Int J Eat Disord. 2015;48:199–205.CrossRefPubMedPubMedCentral Dossat AM, Bodell LP, Williams DL, Eckel LA, Keel PK. Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa: purging disorder and bulimia nervosa. Int J Eat Disord. 2015;48:199–205.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Geliebter A, Ochner CN, Aviram-Friedman R. Appetite-related gut peptides in obesity and binge eating disorder. Am J Lifestyle Med. 2008;2:305–14.CrossRef Geliebter A, Ochner CN, Aviram-Friedman R. Appetite-related gut peptides in obesity and binge eating disorder. Am J Lifestyle Med. 2008;2:305–14.CrossRef
27.
Zurück zum Zitat Lawson EA, Eddy KT, Donoho D, Misra M, Miller KK, Meenaghan E, et al. Appetite-regulating hormones cortisol and peptide YY are associated with disordered eating psychopathology, independent of body mass index. Eur J Endocrinol. 2011;164:253–61.CrossRefPubMedPubMedCentral Lawson EA, Eddy KT, Donoho D, Misra M, Miller KK, Meenaghan E, et al. Appetite-regulating hormones cortisol and peptide YY are associated with disordered eating psychopathology, independent of body mass index. Eur J Endocrinol. 2011;164:253–61.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Martins C, Robertson MD, Morgan LM. Impact of restraint and disinhibition on PYY plasma levels and subjective feelings of appetite. Appetite. 2010;55:208–13.CrossRefPubMed Martins C, Robertson MD, Morgan LM. Impact of restraint and disinhibition on PYY plasma levels and subjective feelings of appetite. Appetite. 2010;55:208–13.CrossRefPubMed
29.
Zurück zum Zitat Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, et al. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. J Clin Endocrinol Metab. 2012;97:E1898–908.CrossRefPubMedPubMedCentral Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, et al. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. J Clin Endocrinol Metab. 2012;97:E1898–908.CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Monteleone P, Martiadis V, Fabrazzo M, Serritella C, Maj M. Ghrelin and leptin responses to food ingestion in bulimia nervosa: implications for binge-eating and compensatory behaviours. Psychol Med. 2003;33:1387–94.CrossRefPubMed Monteleone P, Martiadis V, Fabrazzo M, Serritella C, Maj M. Ghrelin and leptin responses to food ingestion in bulimia nervosa: implications for binge-eating and compensatory behaviours. Psychol Med. 2003;33:1387–94.CrossRefPubMed
31.
Zurück zum Zitat Geliebter A, Gluck ME, Hashim SA. Plasma ghrelin concentrations are lower in binge-eating disorder. J Nutr. 2005;135:1326–30.PubMed Geliebter A, Gluck ME, Hashim SA. Plasma ghrelin concentrations are lower in binge-eating disorder. J Nutr. 2005;135:1326–30.PubMed
32.
Zurück zum Zitat Miller R, Tanofsky-Kraff M, Shomaker LB, Field SE, Hannallah L, Reina SA, et al. Serum leptin and loss of control eating in children and adolescents. Int J Obes. 2014;38:397–403.CrossRef Miller R, Tanofsky-Kraff M, Shomaker LB, Field SE, Hannallah L, Reina SA, et al. Serum leptin and loss of control eating in children and adolescents. Int J Obes. 2014;38:397–403.CrossRef
33.
Zurück zum Zitat Adami G, Campostano A, Cella F, Ferrandes G. Serum leptin level and restrained eating: study with the eating disorder examination. Physiol Behav. 2002;75:189–92.CrossRefPubMed Adami G, Campostano A, Cella F, Ferrandes G. Serum leptin level and restrained eating: study with the eating disorder examination. Physiol Behav. 2002;75:189–92.CrossRefPubMed
34.
Zurück zum Zitat Sabatier N, Leng G, Menzies J. Oxytocin, feeding, and satiety. Front Endocrinol. 2013;4:1–10.CrossRef Sabatier N, Leng G, Menzies J. Oxytocin, feeding, and satiety. Front Endocrinol. 2013;4:1–10.CrossRef
35.
Zurück zum Zitat Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, et al. Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psychiatry. 2013;74:e451–7.CrossRefPubMedPubMedCentral Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, et al. Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psychiatry. 2013;74:e451–7.CrossRefPubMedPubMedCentral
36.•
Zurück zum Zitat Kim Y-R, Kim C-H, Cardi V, Eom J-S, Seong Y, Treasure J. Intranasal oxytocin attenuates attentional bias for eating and fat shape stimuli in patients with anorexia nervosa. Psychoneuroendocrinology. 2014;44:133–42. This study was the first to explore the impact of oxytocin on attentional processes for eating and body-related stimuli in women with AN. Using a double-blind, placebo-controlled within-subject crossover design, data highlighted that experimental administration of intranasal oxytocin reduces attentional vigilance towards food and negative body shape stimuli in patients with AN.CrossRefPubMed Kim Y-R, Kim C-H, Cardi V, Eom J-S, Seong Y, Treasure J. Intranasal oxytocin attenuates attentional bias for eating and fat shape stimuli in patients with anorexia nervosa. Psychoneuroendocrinology. 2014;44:133–42. This study was the first to explore the impact of oxytocin on attentional processes for eating and body-related stimuli in women with AN. Using a double-blind, placebo-controlled within-subject crossover design, data highlighted that experimental administration of intranasal oxytocin reduces attentional vigilance towards food and negative body shape stimuli in patients with AN.CrossRefPubMed
37.
Zurück zum Zitat Fichter M, Pirke K. Effect of experimental and pathological weight loss upon the hypothalamo-pituitary-adrenal axis. Psychoneuroendocrinology. 1986;11:295–305.CrossRefPubMed Fichter M, Pirke K. Effect of experimental and pathological weight loss upon the hypothalamo-pituitary-adrenal axis. Psychoneuroendocrinology. 1986;11:295–305.CrossRefPubMed
38.
Zurück zum Zitat Pike KM, Wilfley D, Hilbert A, Fairburn CG, Dohm F-A, Striegel-Moore RH. Antecedent life events of binge-eating disorder. Psychiatry Res. 2006;142:19–29.CrossRefPubMedPubMedCentral Pike KM, Wilfley D, Hilbert A, Fairburn CG, Dohm F-A, Striegel-Moore RH. Antecedent life events of binge-eating disorder. Psychiatry Res. 2006;142:19–29.CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Welch SL, Doll HA, Fairburn CG. Life events and the onset of bulimia nervosa: a controlled study. Psychol Med. 1997;27:515–22.CrossRefPubMed Welch SL, Doll HA, Fairburn CG. Life events and the onset of bulimia nervosa: a controlled study. Psychol Med. 1997;27:515–22.CrossRefPubMed
40.
Zurück zum Zitat Smyth JM, Wonderlich SA, Heron KE, Sliwinski MJ, Crosby RD, Mitchell JE, et al. Daily and momentary mood and stress are associated with binge eating and vomiting in bulimia nervosa patients in the natural environment. J Consult Clin Psychol. 2007;75:629–38.CrossRefPubMed Smyth JM, Wonderlich SA, Heron KE, Sliwinski MJ, Crosby RD, Mitchell JE, et al. Daily and momentary mood and stress are associated with binge eating and vomiting in bulimia nervosa patients in the natural environment. J Consult Clin Psychol. 2007;75:629–38.CrossRefPubMed
41.
Zurück zum Zitat Fichter MM, Pirke K-M, Holsboer F. Weight loss causes neuroendocrine disturbance: experimental study in healthy starving subjects. Psychiatry Res. 1986;17:61–72.CrossRefPubMed Fichter MM, Pirke K-M, Holsboer F. Weight loss causes neuroendocrine disturbance: experimental study in healthy starving subjects. Psychiatry Res. 1986;17:61–72.CrossRefPubMed
42.•
Zurück zum Zitat Lawson EA, Holsen LM, DeSanti R, Santin M, Meenaghan E, Herzog DB, et al. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa. Eur J Endocrinol. 2013;169:639–47. This study demonstrated that greater cortisol levels were associated with lower homeostatic and hedonic hunger ratings in low-weight and weight-recovered women with AN and healthy controls. Further, cortisol levels predicted significant between-group variance in neural activation in food- and emotion-related brain regions in an fMRI task.CrossRefPubMedPubMedCentral Lawson EA, Holsen LM, DeSanti R, Santin M, Meenaghan E, Herzog DB, et al. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa. Eur J Endocrinol. 2013;169:639–47. This study demonstrated that greater cortisol levels were associated with lower homeostatic and hedonic hunger ratings in low-weight and weight-recovered women with AN and healthy controls. Further, cortisol levels predicted significant between-group variance in neural activation in food- and emotion-related brain regions in an fMRI task.CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Kaye WH, Gwirtsman HE, George DT. The effect of bingeing and vomiting on hormonal secretion. Biol Psychiatry. 1989;25:768–80.CrossRefPubMed Kaye WH, Gwirtsman HE, George DT. The effect of bingeing and vomiting on hormonal secretion. Biol Psychiatry. 1989;25:768–80.CrossRefPubMed
44.
Zurück zum Zitat Weltzin TE, McConaha C, McKee M, Hsu LG, Perel J, Kaye WH. Circadian patterns of cortisol, prolactin, and growth hormonal secretion during bingeing and vomiting in normal weight bulimic patients. Biol Psychiatry. 1991;30:37–48.CrossRefPubMed Weltzin TE, McConaha C, McKee M, Hsu LG, Perel J, Kaye WH. Circadian patterns of cortisol, prolactin, and growth hormonal secretion during bingeing and vomiting in normal weight bulimic patients. Biol Psychiatry. 1991;30:37–48.CrossRefPubMed
45.
Zurück zum Zitat Larsen JK, van Ramshorst B, van Doornen LJP, Geenen R. Salivary cortisol and binge eating disorder in obese women after surgery for morbid obesity. Int J Behav Med. 2009;16:311–5.CrossRefPubMedPubMedCentral Larsen JK, van Ramshorst B, van Doornen LJP, Geenen R. Salivary cortisol and binge eating disorder in obese women after surgery for morbid obesity. Int J Behav Med. 2009;16:311–5.CrossRefPubMedPubMedCentral
46.
Zurück zum Zitat Lavagnino L, Amianto F, Parasiliti Caprino M, Maccario M, Arvat E, Ghigo E, et al. Urinary cortisol and psychopathology in obese binge eating subjects. Appetite. 2014;83:112–6.CrossRefPubMed Lavagnino L, Amianto F, Parasiliti Caprino M, Maccario M, Arvat E, Ghigo E, et al. Urinary cortisol and psychopathology in obese binge eating subjects. Appetite. 2014;83:112–6.CrossRefPubMed
47.
Zurück zum Zitat Elran-Barak R, Sztainer M, Goldschmidt AB, Crow SJ, Peterson CB, Hill LL, et al. Dietary restriction behaviors and binge eating in anorexia nervosa, bulimia nervosa and binge eating disorder: trans-diagnostic examination of the restraint model. Eat Behav. 2015;18:192–6.CrossRefPubMed Elran-Barak R, Sztainer M, Goldschmidt AB, Crow SJ, Peterson CB, Hill LL, et al. Dietary restriction behaviors and binge eating in anorexia nervosa, bulimia nervosa and binge eating disorder: trans-diagnostic examination of the restraint model. Eat Behav. 2015;18:192–6.CrossRefPubMed
48.
Zurück zum Zitat Fries E, Dettenborn L, Kirschbaum C. The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol. 2009;72:67–73.CrossRefPubMed Fries E, Dettenborn L, Kirschbaum C. The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol. 2009;72:67–73.CrossRefPubMed
49.
Zurück zum Zitat Monteleone P, Scognamiglio P, Monteleone AM, Perillo D, Maj M. Cortisol awakening response in patients with anorexia nervosa or bulimia nervosa: relationships to sensitivity to reward and sensitivity to punishment. Psychol Med. 2014;44:2653–60.CrossRefPubMed Monteleone P, Scognamiglio P, Monteleone AM, Perillo D, Maj M. Cortisol awakening response in patients with anorexia nervosa or bulimia nervosa: relationships to sensitivity to reward and sensitivity to punishment. Psychol Med. 2014;44:2653–60.CrossRefPubMed
50.
Zurück zum Zitat Oskis A, Loveday C, Hucklebridge F, Thorn L, Clow A. Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa. Stress. 2012;15:601–7.CrossRefPubMed Oskis A, Loveday C, Hucklebridge F, Thorn L, Clow A. Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa. Stress. 2012;15:601–7.CrossRefPubMed
51.
Zurück zum Zitat Wild B, Wesche D, Schultz J-H, Stroe-Kunold E, Herzog W, Rudofsky G, et al. Trajectories of the cortisol awakening responses during weight gain in anorexia nervosa patients with severe and less severe symptoms. Int J Psychophysiol. 2014;94:272–7.CrossRefPubMed Wild B, Wesche D, Schultz J-H, Stroe-Kunold E, Herzog W, Rudofsky G, et al. Trajectories of the cortisol awakening responses during weight gain in anorexia nervosa patients with severe and less severe symptoms. Int J Psychophysiol. 2014;94:272–7.CrossRefPubMed
52.•
Zurück zum Zitat Monteleone AM, Monteleone P, Serino I, Scognamiglio P, Di Genio M, Maj M. Childhood trauma and cortisol awakening response in symptomatic patients with anorexia nervosa and bulimia nervosa: childhood trauma and HPA axis in eating disorders. Int J Eat Disord. 2015;48:615–21. This study was novel because it examined the impact of childhood trauma on the cortisol awakening response (CAR) in patients with AN and BN. As expected, the CAR differed in eating disorder patients based on prior history of maltreatment. Although non-maltreated individuals with AN and BN had greater and similar CARs to control participants, respectively, both groups of maltreated patients had significantly blunted CARs compared to the non-maltreated groups.CrossRefPubMed Monteleone AM, Monteleone P, Serino I, Scognamiglio P, Di Genio M, Maj M. Childhood trauma and cortisol awakening response in symptomatic patients with anorexia nervosa and bulimia nervosa: childhood trauma and HPA axis in eating disorders. Int J Eat Disord. 2015;48:615–21. This study was novel because it examined the impact of childhood trauma on the cortisol awakening response (CAR) in patients with AN and BN. As expected, the CAR differed in eating disorder patients based on prior history of maltreatment. Although non-maltreated individuals with AN and BN had greater and similar CARs to control participants, respectively, both groups of maltreated patients had significantly blunted CARs compared to the non-maltreated groups.CrossRefPubMed
53.
Zurück zum Zitat Zoccola P, Woody A. Cortisol. In: Wenzel AE, editor. The SAGE encyclopedia of abnormal and clinical psychology thousand oaks, CA: Sage; in press. Zoccola P, Woody A. Cortisol. In: Wenzel AE, editor. The SAGE encyclopedia of abnormal and clinical psychology thousand oaks, CA: Sage; in press.
54.
Zurück zum Zitat Het S, Vocks S, Wolf JM, Hammelstein P, Herpertz S, Wolf OT. Blunted neuroendocrine stress reactivity in young women with eating disorders. J Psychosom Res. 2015;78:260–7.CrossRefPubMed Het S, Vocks S, Wolf JM, Hammelstein P, Herpertz S, Wolf OT. Blunted neuroendocrine stress reactivity in young women with eating disorders. J Psychosom Res. 2015;78:260–7.CrossRefPubMed
55.
Zurück zum Zitat Rosenberg N, Bloch M, Ben Avi I, Rouach V, Schreiber S, Stern N, et al. Cortisol response and desire to binge following psychological stress: comparison between obese subjects with and without binge eating disorder. Psychiatry Res. 2013;208:156–61.CrossRefPubMed Rosenberg N, Bloch M, Ben Avi I, Rouach V, Schreiber S, Stern N, et al. Cortisol response and desire to binge following psychological stress: comparison between obese subjects with and without binge eating disorder. Psychiatry Res. 2013;208:156–61.CrossRefPubMed
56.
Zurück zum Zitat Ginty AT, Phillips AC, Higgs S, Heaney JLJ, Carroll D. Disordered eating behaviour is associated with blunted cortisol and cardiovascular reactions to acute psychological stress. Psychoneuroendocrinology. 2012;37:715–24.CrossRefPubMed Ginty AT, Phillips AC, Higgs S, Heaney JLJ, Carroll D. Disordered eating behaviour is associated with blunted cortisol and cardiovascular reactions to acute psychological stress. Psychoneuroendocrinology. 2012;37:715–24.CrossRefPubMed
57.•
Zurück zum Zitat Van Strien T, Roelofs K, de Weerth C. Cortisol reactivity and distress-induced emotional eating. Psychoneuroendocrinology. 2013;38:677–84. This study aimed to test a theoretical model of emotional eating by examining the relationship between cortisol reactivity to the Trier Social Stress Test and subsequent food intake in individuals high and low on emotional eating. As predicted, low cortisol reactivity, which is thought to reflect chronic stress exposure, was associated with greater food intake, but only in participants with high emotional eating scores.CrossRefPubMed Van Strien T, Roelofs K, de Weerth C. Cortisol reactivity and distress-induced emotional eating. Psychoneuroendocrinology. 2013;38:677–84. This study aimed to test a theoretical model of emotional eating by examining the relationship between cortisol reactivity to the Trier Social Stress Test and subsequent food intake in individuals high and low on emotional eating. As predicted, low cortisol reactivity, which is thought to reflect chronic stress exposure, was associated with greater food intake, but only in participants with high emotional eating scores.CrossRefPubMed
58.
Zurück zum Zitat Baker JH, Girlder SS, Bulik CM. The role of reproductive hormones in the development and maintenance of eating disorders. Expert Rev Obstet Gynecol. 2012;7:573–83.CrossRefPubMedPubMedCentral Baker JH, Girlder SS, Bulik CM. The role of reproductive hormones in the development and maintenance of eating disorders. Expert Rev Obstet Gynecol. 2012;7:573–83.CrossRefPubMedPubMedCentral
59.
Zurück zum Zitat Edler C, Lipson SF, Keel PK. Ovarian hormones and binge eating in bulimia nervosa. Psychol Med. 2007;37:131.CrossRefPubMed Edler C, Lipson SF, Keel PK. Ovarian hormones and binge eating in bulimia nervosa. Psychol Med. 2007;37:131.CrossRefPubMed
60.
Zurück zum Zitat Klump KL, Keel PK, Culbert KM, Edler C. Ovarian hormones and binge eating: exploring associations in community samples. Psychol Med. 2008;38:1749.CrossRefPubMedPubMedCentral Klump KL, Keel PK, Culbert KM, Edler C. Ovarian hormones and binge eating: exploring associations in community samples. Psychol Med. 2008;38:1749.CrossRefPubMedPubMedCentral
61.•
Zurück zum Zitat Klump KL, Keel PK, Racine SE, Burt SA, Neale M, Sisk CL, et al. The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. J Abnorm Psychol. 2013;122:131–7. This study extended prior work on ovarian hormone effects on dysregulated eating across the menstrual cycle by highlighting significant interactive effects between estrogen and progesterone on within-person changes in emotional eating; such interactive effects also explain observed midluteal increases in dysregulated eating given that this hormonal milieu is characterized by the peak in progesterone and a secondary peak in estradiol.CrossRefPubMedPubMedCentral Klump KL, Keel PK, Racine SE, Burt SA, Neale M, Sisk CL, et al. The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. J Abnorm Psychol. 2013;122:131–7. This study extended prior work on ovarian hormone effects on dysregulated eating across the menstrual cycle by highlighting significant interactive effects between estrogen and progesterone on within-person changes in emotional eating; such interactive effects also explain observed midluteal increases in dysregulated eating given that this hormonal milieu is characterized by the peak in progesterone and a secondary peak in estradiol.CrossRefPubMedPubMedCentral
62.
Zurück zum Zitat Klump KL, Racine SE, Hildebrandt B, Burt SA, Neale M, Sisk CL, et al. Influences of ovarian hormones on dysregulated eating: a comparison of associations in women with versus women without binge episodes. Clin Psychol Sci. 2014;2:545–59.CrossRefPubMedPubMedCentral Klump KL, Racine SE, Hildebrandt B, Burt SA, Neale M, Sisk CL, et al. Influences of ovarian hormones on dysregulated eating: a comparison of associations in women with versus women without binge episodes. Clin Psychol Sci. 2014;2:545–59.CrossRefPubMedPubMedCentral
63.
Zurück zum Zitat Hildebrandt BA, Racine SE, Keel PK, Burt SA, Neale M, Boker S, et al. The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle: weight preoccupation across the menstrual cycle. Int J Eat Disord. 2015;48:477–86.CrossRefPubMed Hildebrandt BA, Racine SE, Keel PK, Burt SA, Neale M, Boker S, et al. The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle: weight preoccupation across the menstrual cycle. Int J Eat Disord. 2015;48:477–86.CrossRefPubMed
64.
Zurück zum Zitat Klump KL, Keel PK, Burt SA, Racine SE, Neale MC, Sisk CL, et al. Ovarian hormones and emotional eating associations across the menstrual cycle: an examination of the potential moderating effects of body mass index and dietary restraint. Int J Eat Disord. 2013;46:256–63.CrossRefPubMedPubMedCentral Klump KL, Keel PK, Burt SA, Racine SE, Neale MC, Sisk CL, et al. Ovarian hormones and emotional eating associations across the menstrual cycle: an examination of the potential moderating effects of body mass index and dietary restraint. Int J Eat Disord. 2013;46:256–63.CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Racine SE, Keel PK, Burt SA, Sisk CL, Neale M, Boker S, et al. Individual differences in the relationship between ovarian hormones and emotional eating across the menstrual cycle: a role for personality? Eat Behav. 2013;14:161–6.CrossRefPubMedPubMedCentral Racine SE, Keel PK, Burt SA, Sisk CL, Neale M, Boker S, et al. Individual differences in the relationship between ovarian hormones and emotional eating across the menstrual cycle: a role for personality? Eat Behav. 2013;14:161–6.CrossRefPubMedPubMedCentral
66.
Zurück zum Zitat Klump KL, Keel PK, Sisk C, Burt SA. Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychol Med. 2010;40:1745–53.CrossRefPubMedPubMedCentral Klump KL, Keel PK, Sisk C, Burt SA. Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychol Med. 2010;40:1745–53.CrossRefPubMedPubMedCentral
67.••
Zurück zum Zitat Klump KL, Hildebrandt BA, O’Connor SM, Keel PK, Neale M, Sisk CL, et al. Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study. Psychol Med. 2015;45:3227–37. This study examined, for the first time, within-person changes in genetic risk for eating pathology (i.e., emotional eating) across the menstrual cycle. Findings indicated that genetic influences on emotional eating were two times higher during the post-ovulatory period (characterized by high estradiol and progesterone) as compared to pre-ovulation (characterized by high estradiol and low progesterone).CrossRefPubMed Klump KL, Hildebrandt BA, O’Connor SM, Keel PK, Neale M, Sisk CL, et al. Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study. Psychol Med. 2015;45:3227–37. This study examined, for the first time, within-person changes in genetic risk for eating pathology (i.e., emotional eating) across the menstrual cycle. Findings indicated that genetic influences on emotional eating were two times higher during the post-ovulatory period (characterized by high estradiol and progesterone) as compared to pre-ovulation (characterized by high estradiol and low progesterone).CrossRefPubMed
69.
Zurück zum Zitat Ostlund H, Keller E, Hurd YL. Estrogen receptor gene expression in relation to neuropsychiatric disorders. Ann N Y Acad Sci. 2003;1007:54–63.CrossRefPubMed Ostlund H, Keller E, Hurd YL. Estrogen receptor gene expression in relation to neuropsychiatric disorders. Ann N Y Acad Sci. 2003;1007:54–63.CrossRefPubMed
70.
Zurück zum Zitat Monteleone P, Luisi M, Colurcio B, Casarosa E, Monteleone P, Ioime R, et al. Plasma levels of neuroactive steroids are increased in untreated women with anorexia nervosa or bulimia nervosa. Psychosom Med. 2001;63:62–8.CrossRefPubMed Monteleone P, Luisi M, Colurcio B, Casarosa E, Monteleone P, Ioime R, et al. Plasma levels of neuroactive steroids are increased in untreated women with anorexia nervosa or bulimia nervosa. Psychosom Med. 2001;63:62–8.CrossRefPubMed
71.
Zurück zum Zitat Sundblad C, Bergman L, Eriksson E. High levels of free testosterone in women with bulimia nervosa. Acta Psychiatr Scand. 1994;90:397–8.CrossRefPubMed Sundblad C, Bergman L, Eriksson E. High levels of free testosterone in women with bulimia nervosa. Acta Psychiatr Scand. 1994;90:397–8.CrossRefPubMed
72.
Zurück zum Zitat Miller K, Wexler T, Zha A, Lawson E, Meenaghan E, Misra M, et al. Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa. J Clin Psychiatry. 2007;68:959–65.CrossRefPubMed Miller K, Wexler T, Zha A, Lawson E, Meenaghan E, Misra M, et al. Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa. J Clin Psychiatry. 2007;68:959–65.CrossRefPubMed
73.
Zurück zum Zitat Miller K, Grieco KA, Kilbanski A. Testosterone administration in women with anorexia nervosa. J Clin Endocrinol Metab. 2004;90:1428–43.CrossRefPubMed Miller K, Grieco KA, Kilbanski A. Testosterone administration in women with anorexia nervosa. J Clin Endocrinol Metab. 2004;90:1428–43.CrossRefPubMed
74.
Zurück zum Zitat Hildebrandt T, Grotzinger A, Schulz K. Anorexia nervosa, emotional go/no-go, and the distinct effect of testosterone: disinhibition and androgens in anorexia nervosa. Int J Eat Disord. 2016;49:69–76.CrossRefPubMed Hildebrandt T, Grotzinger A, Schulz K. Anorexia nervosa, emotional go/no-go, and the distinct effect of testosterone: disinhibition and androgens in anorexia nervosa. Int J Eat Disord. 2016;49:69–76.CrossRefPubMed
75.
Zurück zum Zitat Culbert KM, Burt SA, Sisk CL, Nigg JT, Klump KL. The effects of circulating testosterone and pubertal maturation on risk for disordered eating symptoms in adolescent males. Psychol Med. 2014;44:2271–86.CrossRefPubMedPubMedCentral Culbert KM, Burt SA, Sisk CL, Nigg JT, Klump KL. The effects of circulating testosterone and pubertal maturation on risk for disordered eating symptoms in adolescent males. Psychol Med. 2014;44:2271–86.CrossRefPubMedPubMedCentral
76.
Zurück zum Zitat Culbert KM, Breedlove SM, Sisk CL, Burt SA, Klump KL. The emergence of sex differences in risk for disordered eating attitudes during puberty. J Abnorm Psychol. 2013;122:420–32.CrossRefPubMedPubMedCentral Culbert KM, Breedlove SM, Sisk CL, Burt SA, Klump KL. The emergence of sex differences in risk for disordered eating attitudes during puberty. J Abnorm Psychol. 2013;122:420–32.CrossRefPubMedPubMedCentral
77.
Zurück zum Zitat Culbert KM, Breedlove SM, Sisk CL, Keel PK, Neale MC, Boker SM, et al. Age differences in prenatal testosterone’s protective effects on disordered eating symptoms: developmental windows of expression? Behav Neurosci. 2015;129:18–36.CrossRefPubMedPubMedCentral Culbert KM, Breedlove SM, Sisk CL, Keel PK, Neale MC, Boker SM, et al. Age differences in prenatal testosterone’s protective effects on disordered eating symptoms: developmental windows of expression? Behav Neurosci. 2015;129:18–36.CrossRefPubMedPubMedCentral
Metadaten
Titel
Hormonal Factors and Disturbances in Eating Disorders
verfasst von
Kristen M. Culbert
Sarah E. Racine
Kelly L. Klump
Publikationsdatum
01.07.2016
Verlag
Springer US
Erschienen in
Current Psychiatry Reports / Ausgabe 7/2016
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-016-0701-6

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