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Erschienen in:

01.12.2021 | Original Article

How does proximal femur BMD of healthy Irish adults compare to NHANES III? Results of the DXA-HIP Project

verfasst von: Erjiang E., Tingyan Wang, Lan Yang, Mary Dempsey, Attracta Brennan, Ming Yu, Wing P. Chan, Bryan Whelan, Carmel Silke, Miriam O’Sullivan, Bridie Rooney, Aoife McPartland, Gráinne O’Malley, John J. Carey

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2021

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Abstract

Summary

This study examines the distribution of proximal femur bone mineral density in a cohort of healthy Irish adults. These values are similar to those of the NHANES III Caucasian cohorts, supporting international recommendations to use this reference group for calculating DXA T-scores and Z-scores in Irish adults.

Introduction

Bone mineral density (BMD) is widely used in the assessment and monitoring of osteoporosis. International guidelines recommend referencing proximal femur BMD measurements to NHANES III values to calculate T-scores and Z-scores, but their validity for the Irish population has not been established. In this study, we compare BMD values of healthy Irish Caucasian adults to those of Caucasian men and women in the NHANES III cohort study.

Methods

Men and women without bone disease and/or major risk factors for fracture, and/or not taking osteoporosis medication who had a screening DXA scan (GE Lunar, Madison, USA) at one of 3 centres in the West of Ireland were selected for this study. We calculated the mean and standard deviation (SD) used by GE for calculating white female NHANES III T-scores at the femoral neck and total hip sites, and used these values to calculate white female T-scores for men and women across each decade in our study sample. We calculated mean white female T-scores for each decade for both Caucasian men and women in the NHANES III cohort using the published data. Finally, we plotted these results against those of our study population.

Results

In total, 6729 (18.5%) of 36,321 adults were included in our analyses, including 5923 (88%) women. The majority of the study population were aged between 40 and 89 years. Our results show that the proximal femur BMD of healthy Irish men and women is broadly similar to that of the NHANES III reference population, especially middle-aged adults. Results differ for very young and very old adults, likely reflecting the small sample size and a referral bias. Further studies of these populations and other manufacturers could help clarify these uncertainties.

Conclusions

Our results support using the NHANES III reference population to calculate proximal femur adult T-scores and Z-scores to establish the presence or prevalence of osteoporosis in Ireland.

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Titel: How does proximal femur BMD of healthy Irish adults compare to NHANES III? Results of the DXA-HIP Project
verfasst von: Erjiang E.
Tingyan Wang
Lan Yang
Mary Dempsey
Attracta Brennan
Ming Yu
Wing P. Chan
Bryan Whelan
Carmel Silke
Miriam O’Sullivan
Bridie Rooney
Aoife McPartland
Gráinne O’Malley
John J. Carey
Publikationsdatum: 01.12.2021
Verlag: Springer London
Erschienen in: Archives of Osteoporosis / Ausgabe 1/2021
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-021-01034-0

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How does proximal femur BMD of healthy Irish adults compare to NHANES III? Results of the DXA-HIP Project