Erschienen in:
01.12.2000 | Paper Report
HOXA5 regulation of p53 in breast tumours
verfasst von:
Chris Jones
Erschienen in:
Breast Cancer Research
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Ausgabe 1/2000
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Excerpt
Mutational inactivation of p53 occurs in only around 20% of human breast cancers, suggesting other mechanisms for loss of p53 function in these tumours. Although much work has been performed on the control of p53 degradation, information is lacking regarding factors which regulate p53 synthesis.Class I homeobox (HOX) genes are a family of regulatory genes encoding transcription factors that primarily play a crucial role during development. Several indications suggest their involvement in the control of cell growth and, when dysregulated, oncogenesis. …