Skip to main content
Erschienen in: Breast Cancer Research 1/2000

01.12.2000 | Paper Report

HOXA5 regulation of p53 in breast tumours

verfasst von: Chris Jones

Erschienen in: Breast Cancer Research | Ausgabe 1/2000

Einloggen, um Zugang zu erhalten

Excerpt

Mutational inactivation of p53 occurs in only around 20% of human breast cancers, suggesting other mechanisms for loss of p53 function in these tumours. Although much work has been performed on the control of p53 degradation, information is lacking regarding factors which regulate p53 synthesis.Class I homeobox (HOX) genes are a family of regulatory genes encoding transcription factors that primarily play a crucial role during development. Several indications suggest their involvement in the control of cell growth and, when dysregulated, oncogenesis. …
Literatur
1.
Zurück zum Zitat Raman V, Martensen SA, Relsman D, Evron E, Odenwald WF, Jaffee E, Marks J, Sukumar S: Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature. 2000, 408: 974-978. Raman V, Martensen SA, Relsman D, Evron E, Odenwald WF, Jaffee E, Marks J, Sukumar S: Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature. 2000, 408: 974-978.
Metadaten
Titel
HOXA5 regulation of p53 in breast tumours
verfasst von
Chris Jones
Publikationsdatum
01.12.2000
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2000
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2000-66711

Weitere Artikel der Ausgabe 1/2000

Breast Cancer Research 1/2000 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.