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Clinical and Translational Oncology

Erschienen in:

19.06.2019 | Research Article

Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via P53/P21 pathway

verfasst von: G. Li, R. Zhang, X. Zhang, S. Shao, F. Hu, Y. Feng

Erschienen in: Clinical and Translational Oncology | Ausgabe 4/2020

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Abstract

Purpose

The purpose of this study was to evaluate effect of MSCs on CRC cell.

Methods

in this study the MSC was isolated from CRC tissue, its effect on CRC cells was investigated in vivo and vitro, and the underlying mechanism was investigated.

Results

In this study we found that MSC-CM could promote colorectal cancer cells escape from senescence both in vitro and in vivo. Further research we demonstrated that MSC-CM acted in colorectal cancer cells senescence through P53/P21 pathway. Next we found that MSC-CM regulate P53 via posttranscription method.

Conclusion

Collectively, these results reveal that MSCs can help colorectal cancer cells defend against senescence through P53/P21 pathway, which may be a new strategy for colorectal cancer therapy.

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Titel: Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via P53/P21 pathway
verfasst von: G. Li
R. Zhang
X. Zhang
S. Shao
F. Hu
Y. Feng
Publikationsdatum: 19.06.2019
Verlag: Springer International Publishing
Erschienen in: Clinical and Translational Oncology / Ausgabe 4/2020
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-019-02152-5

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via P53/P21 pathway

Abstract

Purpose

Methods

Results

Conclusion

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Update Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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