Background
Results
Cell line specific responses to C. trachomatis active and persistent infection
Affymetrix ID | Gene name | Gene symbol | Log2 fold change | Absolute fold change |
---|---|---|---|---|
8102800
| Solute carrier family 7, (cationic amino acid transporter, y + system) member 11 | SLC7A11 | 3,50 | 11,28 |
8154381
| Chromosome 9 open reading frame 150 | C9orf150 | 3,25 | 9,51 |
7982868
| ChaC, cation transport regulator homolog 1 (E. coli) | CHAC1 | 2,63 | 6,18 |
7928308
| DNA-damage-inducible transcript 4 | DDIT4 | 2,41 | 5,33 |
7902290
| Hystathionase (cystathionine gamma-lyase) | CTH | 1,89 | 3,72 |
8178086
| Heat shock 70 kDa protein 1A /// heat shock 70 kDa protein 1B | HSPA1A /// HSPA1B | -1,78 | 3,43 |
8179324
| ||||
8118314
| ||||
8179322
| ||||
8118310
| ||||
8166585
| Hypothetical locus FLJ32742 | FLJ32742 | 1,77 | 3,41 |
7920873
| Small nucleolar RNA, H/ACA box 42 | SNORA42 | 1,74 | 3,35 |
7899436
| Sestrin 2 | SESN2 | 1,66 | 3,17 |
8139737
| Phosphoserine phosphatase | PSPH | 1,66 | 3,17 |
8060344
| Tribbles homolog 3 (Drosophila) | TRIB3 | 1,62 | 3,08 |
8122724
| UL16 binding protein 1 | ULBP1 | 1,61 | 3,06 |
8143341
| Jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) | JHDM1D | 1,61 | 3,06 |
8084219
| Kelch-like 24 (Drosophila) | KLHL24 | 1,59 | 3,03 |
Affymetrix ID | Gene name | Gene symbol | Log2 fold change | Absolute fold change |
---|---|---|---|---|
7943413
| Baculoviral IAP repeat-containing 3 | BIRC3 | 2,14 | 4,41 |
8124650
| Ubiquitin D /// gamma-aminobutyric acid (GABA) B receptor, 1 | UBD /// GABBR1 | 2,00 | 4,00 |
8178295
| ||||
7954090
| Epithelial membrane protein 1 | EMP1 | 1,96 | 3,90 |
8122265
| Tumor necrosis factor, alpha-induced protein 3 | TNFAIP3 | 1,95 | 3,87 |
7984259
| RNA, U5B small nuclear 1 | RNU5B-1 | 1,72 | 3,29 |
7908072
| Laminin, gamma 2 | LAMC2 | 1,65 | 3,13 |
Affymetrix ID | Gene name | Gene symbol | Log2 fold change | Absolute fold change |
---|---|---|---|---|
8102800
| Solute carrier family 7, (cationic amino acid transporter, y + system) member 11 | SLC7A11 | 3,77 | 13,56 |
7982868
| ChaC, cation transport regulator homolog 1 (E. coli) | CHAC1 | 3,28 | 9,71 |
7928308
| DNA-damage-inducible transcript 4 | DDIT4 | 2,47 | 5,55 |
8146934
| Lymphocyte antigen 96 | LY96 | 2,09 | 4,26 |
8154381
| Chromosome 9 open reading frame 150 | C9orf150 | 1,96 | 3,89 |
8143341
| Jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) | JHDM1D | 1,93 | 3,81 |
8122724
| UL16 binding protein 1 | ULBP1 | 1,85 | 3,61 |
8174361
| TSC22 domain family, member 3 | TSC22D3 | 1,75 | 3,36 |
8122202
| v-myb myeloblastosis viral oncogene homolog (avian) | MYB | -1,73 | 3,31 |
7912157
| ERBB receptor feedback inhibitor 1 | ERRFI1 | 1,71 | 3,27 |
8156043
| Phosphoserine aminotransferase 1 | PSAT1 | 1,71 | 3,27 |
8139737
| Phosphoserine phosphatase | PSPH | 1,70 | 3,26 |
7899436
| Sestrin 2 | SESN2 | 1,65 | 3,14 |
7902290
| Cystathionase (cystathionine gamma-lyase) | CTH | 1,59 | 3,02 |
8049542
| Leucine rich repeat (in FLII) interacting protein 1 | LRRFIP1 | 1,59 | 3,00 |
Affymetrix ID | Gene name | Gene symbol | Log2 fold change | Absolute fold change |
---|---|---|---|---|
8027002
| Growth differentiation factor 15 | GDF15 | 3,32 | 10,01 |
7958262
| t-complex 11 (mouse)-like 2 | TCP11L2 | 2,96 | 7,79 |
7954090
| Epithelial membrane protein 1 | EMP1 | 2,59 | 6,03 |
8158671
| Argininosuccinate synthetase 1 | ASS1 | 2,10 | 4,29 |
8152703
| F-box protein 32 | FBXO32 | 2,09 | 4,25 |
7982868
| ChaC, cation transport regulator homolog 1 (E. coli) | CHAC1 | 2,09 | 4,25 |
8048319
| Villin 1 | VIL1 | -2,04 | 4,10 |
8066431
| Adenosine deaminase | ADA | -2,00 | 3,99 |
8008885
| microRNA 21 | MIR21 | 1,99 | 3,96 |
8034122
| SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) | SPC24 | -1,96 | 3,89 |
8119898
| Vascular endothelial growth factor A | VEGFA | 1,91 | 3,77 |
8117429
| Histone cluster 1, H2bi | HIST1H2BI | -1,88 | 3,69 |
7919591
| Family with sequence similarity 72, member D /// family with sequence similarity 72, | FAM72D / FAM72A / FAM72B / FAM72C | -1,84 | 3,60 |
8122724
| UL16 binding protein 1 | ULBP1 | 1,81 | 3,49 |
8007071
| Cell division cycle 6 homolog (S. cerevisiae) | CDC6 | -1,80 | 3,49 |
8113073
| Arrestin domain containing 3 | ARRDC3 | 1,79 | 3,45 |
8068684
| Family with sequence similarity 3, member B | FAM3B | -1,76 | 3,40 |
7989146
| Meiosis-specific nuclear structural 1 | MNS1 | -1,70 | 3,24 |
8109712
| Hyaluronan-mediated motility receptor (RHAMM) | HMMR | -1,68 | 3,20 |
8113278
| Lix1 homolog (chicken) | LIX1 | -1,66 | 3,15 |
7953943
| GABA(A) receptor-associated protein like 1 | GABARAPL1 | 1,65 | 3,15 |
8071212
| CDC45 cell division cycle 45-like (S. cerevisiae) | CDC45L | -1,65 | 3,14 |
8009243
| Chromosome 17 open reading frame 60 | C17orf60 | 1,65 | 3,13 |
8062064
| Myosin, heavy chain 7B, cardiac muscle, beta | MYH7B | -1,64 | 3,11 |
8021470
| Phorbol-12-myristate-13-acetate-induced protein 1 | PMAIP1 | 1,62 | 3,08 |
8095744
| Amphiregulin | AREG | 1,62 | 3,08 |
7989647
| KIAA0101 /// casein kinase 1, gamma 1 | KIAA0101 /// CSNK1G1 | -1,61 | 3,06 |
7914878
| Arsenic transactivated protein 1 | LOC100289612 | -1,61 | 3,05 |
8165663
| Glycerol-3-phosphate acyltransferase, mitochondrial | GPAM | -1,60 | 3,04 |
8077731
| Fanconi anemia, complementation group D2 | FANCD2 | -1,59 | 3,03 |
8151871
| Cyclin E2 | CCNE2 | -1,59 | 3,03 |
8157524
| Toll-like receptor 4 | TLR4 | 1,59 | 3,03 |
8104234
| Thyroid hormone receptor interactor 13 | TRIP13 | -1,59 | 3,01 |
Gene signatures of active and persistent C. trachomatis infection
Selected genes of interest
Affymetrix ID | Gene name | Gene symbol | Log2 fold change | Absolute fold change | Log2 fold change | Absolute fold change |
---|---|---|---|---|---|---|
LCC-18 | LCC-18 | CNDT-2 | CNDT-2 | |||
PI v NI | PI v NI | PI v NI | PI v NI | |||
Microarray/ qPCR | Microrray/qPCR | Microarray/qPCR | Microarray/qPCR | |||
8042310
| Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | SLC1A4 | NC | NC | 1,37 | 2,58 |
0,94 | 1,9 | 1,12 | 2,2 | |||
8068361
| Solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | SLC5A3 | 1,2 | 2,3 | NC | NC |
1,28 | 2,4 | 0,18 | 1,1 | |||
8003298
| Solute carrier family 7 (cationic amino acid transporter, y + system), member 5 | SLC7A5 | NC | NC | 1,26 | 2,4 |
-0,6 | 1,4 | 0,48 | 1,4 | |||
8102800
| Solute carrier family 7, (cationic amino acid transporter, y + system) member 11 | SLC7A11 | 0,84 | 1,8 | 3,76 | 13,6 |
1,63 | 3,1 | 1.55 | 2,9 | |||
8017843
| Solute carrier family 16, member 6 (monocarboxylic acid transporter 7 | SLC16A6 | 1,26 | 2,4 | 0,88 | 1,8 |
0,68 | 1,6 | 1,67 | 3,2 | |||
8010673
| Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | SLC25A10 | -0,79 | 1,7 | -1,07 | 2,1 |
-0,11 | 1,1 | -1,49 | 2,5 | |||
8012450
| Solute carrier family 25, member 35 | SLC25A35 | -0,96 | 2 | -0,43 | 1,4 |
-0,49 | 1,4 | -0,79 | 1,7 | |||
8162586
| Solute carrier family 35,member D2 UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter | SLC35D2 | 0,96 | 2 | 0,57 | 1,5 |
0,74 | 1,7 | 0,8 | 1,7 | |||
7962559
| Solute carrier family 38, member 4, Na(+)-coupled neutral amino acid transporter | SLC38A4 | 1,48 | 2,8 | -1,1 | 2,2 |
0,92 | 1,9 | -0,56 | 1,4 | |||
7965964
| Solute carrier family 41, member 2, plasma-membrane magnesium transporter | SLC41A2 | 0,4 | 1,3 | 1,18 | 2,3 |
0,45 | 1,4 | 1,62 | 3,1 |
Affymetrix ID | Gene name | Gene symbol | Log2 fold change | Absolute fold change | Log2 fold change | Absolute fold change |
---|---|---|---|---|---|---|
LCC-18 | LCC-18 | CNDT-2 | CNDT-2 | |||
PI v NI | PI v NI | PI v NI | PI v NI | |||
7953943
| GABA(A) receptor-associated protein like 1 | GABARAPL | 1,65 | 3,2 | 1,10 | 2,0 |
7964759
| glutamate receptor interacting protein 1 | GRIP1 | 1,14 | 2,2 | NC | NC |
7951703
| Dopamine receptor 2 | DRD2 | 1,02 | 2,0 | NC | NC |
8039378
| Synaptotagmin5 | SYT5 | 1,3 | 2,5 | 0,54 | 1,5 |
7948588
| Synaptotagmin7 | SYT7 | -1,15 | 2,1 | NC | NC |