Skip to main content
main-content

01.12.2012 | Research | Ausgabe 1/2012 Open Access

Reproductive Biology and Endocrinology 1/2012

Hyberbaric oxygen increases atresia in normal & steroid induced PCO rat ovaries

Zeitschrift:
Reproductive Biology and Endocrinology > Ausgabe 1/2012
Autoren:
Alev Atis, Yavuz Aydin, Filiz Ciftci, Damlanur Sakız, Abdullah Arslan, Akın S Toklu, Melahat Donmez, Nimet Goker
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7827-10-11) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

AA has designed the study, YA has dealt with statistics, FC has dealt with rats, DS has assessed the microscopy, AArslan and AST has given the HBOT, MD has reviewed the drafts, NG read & approved the final version of the manuscript. All authors read and approved the final manuscript.

Abstract

Background

In this study, we investigated the effect of hyperbaric oxygen therapy (HBOT) on the morphology of estradiol valerate (EV) induced polycystic ovary (PCO) to find a new treatment modality for improvement of PCO.

Methods

The rats were divided into four groups. Group1, control; group 2, PCO group; group 3, PCO with HBOT group and group 4, normal ovary with HBOT. PCO was induced by a single intramuscular injection of 4 mg EV in adult cycling rats. Other rats with normal ovaries had oil injection as placebo. HBOT was applied to third and fourth groups for six weeks. Histopathologic evaluation of ovaries of all groups were performed & compared.

Results

Six weeks of HBOT was resulted in increase in follicular atresia, decrease in the number of primary, secondary, tertiary follicles and decrease in the number of fresh corpus luteum in normal rat ovary. HBOT on polycystic rat ovary, resulted in significant increase in atretic follicles which were already present.

Conclusions

HBOT of six weeks itself, changed ovarian morphology in favor of atresia both in PCO group and control group. This result of aggravated follicular atresia after HBOT on EV induced PCO may be due to long-term exposure in our protocol which with this state seems to be inapplicable in the improvement of PCO morphology.
Zusatzmaterial
Authors’ original file for figure 1
12958_2011_948_MOESM1_ESM.jpeg
Authors’ original file for figure 2
12958_2011_948_MOESM2_ESM.jpeg
Authors’ original file for figure 3
12958_2011_948_MOESM3_ESM.jpeg
Authors’ original file for figure 4
12958_2011_948_MOESM4_ESM.jpeg
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2012

Reproductive Biology and Endocrinology 1/2012 Zur Ausgabe

Neu im Fachgebiet Gynäkologie und Geburtshilfe


 

Meistgelesene Bücher aus dem Fachgebiet

2014 | Buch

Perikonzeptionelle Frauenheilkunde

Fertilitätserhalt, Prävention und Management von Schwangerschaftsrisiken

Ein Praxisbuch für alle, die in der Beratung und Betreuung von Schwangeren und Paaren mit Kinderwunsch tätig sind. Die Herausgeber und Autoren haben alle wichtigen Informationen zusammengetragen, um Frauen sicher zu beraten, zu betreuen und kompetent Verantwortung zu übernehmen.

Herausgeber:
Christian Gnoth, Peter Mallmann

2014 | Buch

Praxisbuch Gynäkologische Onkologie

Das Nachschlagewerk für alle Ärzte in Klinik und Praxis, die Patientinnen mit bösartigen Tumoren des Genitales und der Mamma behandeln. Dieses Buch gibt in kompakter Weise einfach umsetzbare Handlungsanweisungen zum diagnostischen und therapeutischen Vorgehen und Hilfestellungen für die optimale Versorgung der Patientinnen.

Herausgeber:
Edgar Petru, Walter Jonat, Daniel Fink, Ossi R. Köchli

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Gynäkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise