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Clinical and Experimental Nephrology

Erschienen in:

01.06.2015 | Original Article

Hypoadiponectinemia correlates with arterial stiffness in kidney transplantation patients

verfasst von: Guan-Jin Ho, Ming-Che Lee, Chung-Jen Lee, Yen-Cheng Chen, Bang-Gee Hsu

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 3/2015

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Abstract

Background

Adiponectin is a fat-derived hormone produced and secreted exclusively by adipocytes that have anti-atherosclerotic effects. The aim of this study was to evaluate the relationship between fasting serum adiponectin levels and arterial stiffness among kidney transplant (KT) patients.

Methods

Fasting blood samples were obtained from 69 KT patients. Brachial–ankle pulse wave velocity (baPWV) was measured in the right or left brachial artery to the ankle segments using an automatic pulse wave analyzer. Plasma adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Left or right baPWV values of >14.0 m/s were used to define the high arterial stiffness group.

Results

Thirty-five KT patients (35/69; 50.7 %) were defined in high arterial stiffness group. Diabetes (P = 0.013), smoking (P = 0.001), KT duration (P < 0.001), body weight (P = 0.013), waist circumference (P = 0.013), body mass index (P = 0.001), fasting glucose (P = 0.013), systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.008), and pulse pressure (P = 0.003) were higher, while serum adiponectin level (P = 0.004) was lower in high arterial stiffness group compared with low arterial stiffness group. Multivariate logistic regression analysis showed that adiponectin (odds ratio 0.90, 95 % confidence interval 0.81–0.99, P = 0.034) was still the independent predictors of arterial stiffness among the KT patients.

Conclusion

Serum fasting adiponectin level was inversely associated with arterial stiffness among KT patients.

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Titel: Hypoadiponectinemia correlates with arterial stiffness in kidney transplantation patients
verfasst von: Guan-Jin Ho
Ming-Che Lee
Chung-Jen Lee
Yen-Cheng Chen
Bang-Gee Hsu
Publikationsdatum: 01.06.2015
Verlag: Springer Japan
Erschienen in: Clinical and Experimental Nephrology / Ausgabe 3/2015
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-014-1010-1

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Abstract

Background

Methods

Results

Conclusion

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