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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 1/2009

01.02.2009 | Review

Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair

verfasst von: Christopher L Murphy, Brendan L Thoms, Rasilaben J Vaghjiani, Jérôme E Lafont

Erschienen in: Arthritis Research & Therapy | Ausgabe 1/2009

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Abstract

In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matrix synthesis have recently been examined, and specific manipulation of hypoxia-induced pathways is now considered to have potential therapeutic application to maintenance and repair of articular cartilage.
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Literatur
1.
Mitchell P: Coupling of phosphorylation to electron and hydrogen transfer by a chemiosmotic type of mechanism. Nature. 1961, 191: 144-148. 10.1038/191144a0.CrossRefPubMed
2.
3.
Gendron A, Kouassi E, Nuara S, Cossette C, D'Angelo G, Geadah D, du Souich P, Teitelbaum J: Transient middle cerebral artery occlusion influence on systemic oxygen homeostasis and erythropoiesis in Wistar rats. Stroke. 2004, 35: 1979-1984. 10.1161/01.STR.0000133691.07945.f2.CrossRefPubMed
4.
Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS: Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001, 15: 2865-2876.PubMedCentralPubMed
5.
Goshima J, Goldberg VM, Caplan AI: The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop Relat Res. 1991, 269: 274-283.PubMed
6.
Pechak DG, Kujawa MJ, Caplan AI: Morphology of bone development and bone remodeling in embryonic chick limbs. Bone. 1986, 7: 459-472. 10.1016/8756-3282(86)90005-0.CrossRefPubMed
7.
Brighton CT, Heppenstall RB: Oxygen tension in zones of the epiphyseal plate, the metaphysis and diaphysis. An in vitro and in vivo study in rats and rabbits. J Bone Joint Surg Am. 1971, 53: 719-728.PubMed
8.
Lund-Olesen K: Oxygen tension in synovial fluids. Arthritis Rheum. 1970, 13: 769-776. 10.1002/art.1780130606.CrossRefPubMed
9.
Silver IA: Measurement of pH and ionic composition of pericellular sites. Philos Trans R Soc Lond B Biol Sci. 1975, 271: 261-272. 10.1098/rstb.1975.0050.CrossRefPubMed
10.
Treuhaft PS, DJ MC: Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum. 1971, 14: 475-484. 10.1002/art.1780140407.CrossRefPubMed
11.
Lafont JE, Talma S, Murphy CL: Hypoxia-inducible factor 2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype. Arthritis Rheum. 2007, 56: 3297-3306. 10.1002/art.22878.CrossRefPubMed
12.
Lafont JE, Talma S, Hopfgarten C, Murphy CL: Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. J Biol Chem. 2008, 283: 4778-4786. 10.1074/jbc.M707729200.CrossRefPubMed
13.
Domm C, Schunke M, Christesen K, Kurz B: Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cartilage. 2002, 10: 13-22. 10.1053/joca.2001.0477.CrossRefPubMed
14.
Bargahi A, Rabbani-Chadegani A: Angiogenic inhibitor protein fractions derived from shark cartilage. Biosci Rep. 2008, 28: 15-21. 10.1042/BSR20070029.CrossRefPubMed
15.
Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995, 92: 5510-5514. 10.1073/pnas.92.12.5510.PubMedCentralCrossRefPubMed
16.
Maynard MA, Qi H, Chung J, Lee EH, Kondo Y, Hara S, Conaway RC, Conaway JW, Ohh M: Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. J Biol Chem. 2003, 278: 11032-11040. 10.1074/jbc.M208681200.CrossRefPubMed
17.
Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N: Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem Biophys Res Commun. 2001, 287: 808-813. 10.1006/bbrc.2001.5659.CrossRefPubMed
18.
Provot S, Schipani E: Fetal growth plate: a developmental model of cellular adaptation to hypoxia. Ann N Y Acad Sci. 2007, 1117: 26-39. 10.1196/annals.1402.076.CrossRefPubMed
19.
Pfander D, Cramer T, Schipani E, Johnson RS: HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci. 2003, 116: 1819-1826. 10.1242/jcs.00385.CrossRefPubMed
20.
Stewart AJ, Houston B, Farquharson C: Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes. J Cell Physiol. 2006, 206: 435-440. 10.1002/jcp.20481.CrossRefPubMed
21.
Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E: Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004, 131: 2497-2508. 10.1242/dev.01138.CrossRefPubMed
22.
Gelse K, Pfander D, Obier S, Knaup KX, Wiesener M, Hennig FF, Swoboda B: The role of HIF-1alpha for the integrity of articular cartilage in murine knee joints. Arthritis Res Ther. 2008, 10: R111-10.1186/ar2508.PubMedCentralCrossRefPubMed
23.
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P: 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003, 3: 363-375. 10.1016/S1535-6108(03)00077-1.CrossRefPubMed
24.
Falchuk KH, Goetzl EJ, Kulka JP: Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis. Am J Med. 1970, 49: 223-231. 10.1016/S0002-9343(70)80078-X.CrossRefPubMed
25.
Adams MA: The mechanical environment of chondrocytes in articular cartilage. Biorheology. 2006, 43: 537-545.PubMed
26.
Glowacki J, Trepman E, Folkman J: Cell shape and phenotypic expression in chondrocytes. Proc Soc Exp Biol Med. 1983, 172: 93-98.CrossRefPubMed
27.
Mark von der K, Gauss V, Mark von der H, Muller P: Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature. 1977, 267: 531-532. 10.1038/267531a0.CrossRefPubMed
28.
Watt FM: Effect of seeding density on stability of the differentiated phenotype of pig articular chondrocytes in culture. J Cell Sci. 1988, 89: 373-378.PubMed
29.
Aigner T, Fundel K, Saas J, Gebhard PM, Haag J, Weiss T, Zien A, Obermayr F, Zimmer R, Bartnik E: Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum. 2006, 54: 3533-3544. 10.1002/art.22174.CrossRefPubMed
30.
Urban JP: The chondrocyte: a cell under pressure. Br J Rheumatol. 1994, 33: 901-908. 10.1093/rheumatology/33.10.901.CrossRefPubMed
31.
Lane Smith R, Trindade MC, Ikenoue T, Mohtai M, Das P, Carter DR, Goodman SB, Schurman DJ: Effects of shear stress on articular chondrocyte metabolism. Biorheology. 2000, 37: 95-107.PubMed
32.
Smith RL, Carter DR, Schurman DJ: Pressure and shear differentially alter human articular chondrocyte metabolism: a review. Clin Orthop Relat Res. 2004, 427 (Suppl): S89-95.PubMed
33.
Monfort J, Garcia-Giralt N, Lopez-Armada MJ, Monllau JC, Bonilla A, Benito P, Blanco FJ: Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation. Arthritis Res Ther. 2006, 8: R149-10.1186/ar2042.PubMedCentralCrossRefPubMed
34.
Gibson JS, Milner PI, White R, Fairfax TP, Wilkins RJ: Oxygen and reactive oxygen species in articular cartilage: modulators of ionic homeostasis. Pflugers Arch. 2008, 455: 563-573. 10.1007/s00424-007-0310-7.CrossRefPubMed
35.
Murphy CL, Sambanis A: Effect of oxygen tension and alginate encapsulation on restoration of the differentiated phenotype of passaged chondrocytes. Tissue Eng. 2001, 7: 791-803. 10.1089/107632701753337735.CrossRefPubMed
36.
Murphy CL, Polak JM: Control of human articular chondrocyte differentiation by reduced oxygen tension. J Cell Physiol. 2004, 199: 451-459. 10.1002/jcp.10481.CrossRefPubMed
37.
Adesida AB, Grady LM, Khan WS, Hardingham TE: The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia. Arthritis Res Ther. 2006, 8: R61-10.1186/ar1929.PubMedCentralCrossRefPubMed
38.
Robins JC, Akeno N, Mukherjee A, Dalal RR, Aronow BJ, Koopman P, Clemens TL: Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone. 2005, 37: 313-322. 10.1016/j.bone.2005.04.040.CrossRefPubMed
39.
Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E: HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007, 134: 3917-3928. 10.1242/dev.008441.CrossRefPubMed
40.
De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, Hedrick MH: Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 2003, 174: 101-109. 10.1159/000071150.CrossRefPubMed
41.
Kuznetsov SA, Mankani MH, Gronthos S, Satomura K, Bianco P, Robey PG: Circulating skeletal stem cells. J Cell Biol. 2001, 153: 1133-1140. 10.1083/jcb.153.5.1133.PubMedCentralCrossRefPubMed
42.
De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP: Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001, 44: 1928-1942. 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P.CrossRefPubMed
43.
Murphy JM, Fink DJ, Hunziker EB, Barry FP: Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003, 48: 3464-3474. 10.1002/art.11365.CrossRefPubMed
44.
Ponticiello MS, Schinagl RM, Kadiyala S, Barry FP: Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy. J Biomed Mater Res. 2000, 52: 246-255. 10.1002/1097-4636(200011)52:2<246::AID-JBM2>3.0.CO;2-W.CrossRefPubMed
45.
Adachi N, Ochi M: [Regenerative medicine for rheumatoid arthritis – current status and problems]. Nippon Rinsho. 2005, 63 (Suppl 1): 666-671.PubMed
46.
Kanichai M, Ferguson D, Prendergast PJ, Campbell VA: Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha. J Cell Physiol. 2008, 216: 708-715. 10.1002/jcp.21446.CrossRefPubMed
47.
Lennon DP, Edmison JM, Caplan AI: Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis. J Cell Physiol. 2001, 187: 345-355. 10.1002/jcp.1081.CrossRefPubMed
48.
Mueller MB, Tuan RS: Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis Rheum. 2008, 58: 1377-1388. 10.1002/art.23370.PubMedCentralCrossRefPubMed
49.
de Crombrugghe B, Lefebvre V, Nakashima K: Regulatory mechanisms in the pathways of cartilage and bone formation. Curr Opin Cell Biol. 2001, 13: 721-727. 10.1016/S0955-0674(00)00276-3.CrossRefPubMed
50.
Khan WS, Adesida AB, Hardingham TE: Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients. Arthritis Res Ther. 2007, 9: R55-10.1186/ar2211.PubMedCentralCrossRefPubMed
51.
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim Av, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ: Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001, 292: 468-472. 10.1126/science.1059796.CrossRefPubMed
52.
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM: Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem. 2004, 279: 38458-38465. 10.1074/jbc.M406026200.CrossRefPubMed
53.
Mahon PC, Hirota K, Semenza GL: FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001, 15: 2675-2686. 10.1101/gad.924501.PubMedCentralCrossRefPubMed
54.
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK: FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 2002, 16: 1466-1471. 10.1101/gad.991402.PubMedCentralCrossRefPubMed
55.
Harwood R, Grant ME, Jackson DS: Collagen biosynthesis. Characterization of subcellular fractions from embyonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxylases. Biochem J. 1974, 144: 123-130.PubMedCentralCrossRefPubMed
56.
Hofbauer KH, Gess B, Lohaus C, Meyer HE, Katschinski D, Kurtz A: Oxygen tension regulates the expression of a group of pro-collagen hydroxylases. Eur J Biochem. 2003, 270: 4515-4522. 10.1046/j.1432-1033.2003.03846.x.CrossRefPubMed
57.
Terkhorn SP, Bohensky J, Shapiro IM, Koyama E, Srinivas V: Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity. J Cell Physiol. 2007, 210: 257-265. 10.1002/jcp.20873.CrossRefPubMed
58.
Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J: HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J. 2003, 22: 4082-4090. 10.1093/emboj/cdg392.PubMedCentralCrossRefPubMed
59.
Fang J, Yan L, Shing Y, Moses MA: HIF-1alpha-mediated up-regulation of vascular endothelial growth factor, independent of basic fibroblast growth factor, is important in the switch to the angiogenic phenotype during early tumorigenesis. Cancer Res. 2001, 61: 5731-5735.PubMed
60.
Zhang W, Petrovic JM, Callaghan D, Jones A, Cui H, Howlett C, Stanimirovic D: Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol. 2006, 174: 63-73. 10.1016/j.jneuroim.2006.01.014.CrossRefPubMed
Metadaten
Titel
Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair
verfasst von
Christopher L Murphy
Brendan L Thoms
Rasilaben J Vaghjiani
Jérôme E Lafont
Publikationsdatum
01.02.2009
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 1/2009
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2574

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