Background
Results
Identification of a post-senescence neoplastic emergence (PSNE) gene expression signature
The PSNE signature is relevant of premalignant states or established epithelial cancers
The PSNE signature is enriched in genes belonging to a pathway of xenobiotic metabolism
Category
|
Term
| P-value |
Count up
| % up |
Count down
| % down |
group
|
---|---|---|---|---|---|---|---|
GO molecular function
| |||||||
GO:0008081 | Phosphoric diester hydrolase activity | 0.00207 | 5 | 1.74 | 2 | 0.69 | 1 |
GO:0051082 | Unfolded protein binding | 0.00225 | 5 | 1.74 | 3 | 1.04 | 2 |
GO:0016491 | Oxidoreductase activity | 0.00292 | 21 | 7.34 | 1 | 0.34 | 3 |
GO:0008483 | Transaminase activity | 0.0041 | 0 | 0 | 4 | 1.39 | 4 |
GO:0015175 | Neutral amino acid transmembrane transporter activity | 0.0042 | 0 | 0 | 4 | 1.39 | 5 |
GO biological process
| |||||||
GO:0042180 | Cellular ketone metabolic process | 2.02E-8 | 11 | 3.78 | 20 | 6.87 | 6 |
GO:0009605 | Response to external stimulus | 1.16E-6 | 24 | 8.24 | 13 | 4.46 | 7 |
GO:0008544 | Epidermis development | 2.44E-6 | 12 | 4.12 | 3 | 1.03 | 8 |
GO:0006950 | Response to stress | 6.51E-6 | 31 | 10.65 | 22 | 7.56 | 9 |
GO:0042221 | Response to chemical stimulus | 1.47E-5 | 28 | 9.62 | 15 | 5.15 | 10 |
KEGG pathway
| P-value |
Genes
|
---|---|---|
Hsa00980 : Metabolism of xenobiotics by cytochrome P450 | 0.0011 | AKR1C3, AKR1C2, GSTA4, ADH5, GSTP1, MGST2, ALDH3A1 |
Hsa00970 : Aminoacyl-tRNA biosynthesis | 0.0087 | IARS, WARS, AARS, GARS, MARS |
Hsa00260 : Glycine, serine and threonine metabolism | 0.0234 | CTH, SHMT2, PSAT1, CBS |
Hsa00010 : Glycolysis/Gluconeogenesis | 0.0315 | LDHA, ADH5, BPGM, PCK2, ALDH3A1 |
Hsa05020 : Prion diseases | 0.0322 | IL1B, HSPA5, PRNP, IL1A |
Ingenuity canonical pathways
| P-value |
Genes
|
---|---|---|
Metabolism of xenobiotics by cytochrome P450 | 0.000126 | ADH5, AKR1C2, AKR1C3, MGST2, GSTA4, CYP4B1, ALDH3A1, GSTP1 |
Glycine, Serine and Threonine Metabolism | 0.00138 | PSAT1, CBS, GARS, CTH, PLCH2, PLCL1, SHMT2 |
Interferon signaling | 0.000257 | IFIT1, OAS1, MX1, IFNGR1, PSMB8 |
Aminoacyl-tRNA biosynthesis | 0.000295 | WARS, GARS, AARS, MARS, IARS |
Aldosterone signaling in epithelial cells | 0.001175 | HSPA8, CRYAB, DNAJB4, HSPA9, PLCH2, DNAJA1, HSPA5, PLCL1, HSPB1 |