Erschienen in:
01.12.2001 | Paper Report
Identification of a novel chondrocyte-specific protein
verfasst von:
Tonia Vincent
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
Cell-based therapies based upon regeneration of cartilage involve either harvesting autologous chondrocytes or using mesenchymal stem cells which can be driven into a chondrocytic phenotype in vitro. For the latter technique cell-specific markers are essential to differentiate mesenchymal stem cell lineages, which include chondrocytes, osteoblasts and fibroblasts. The aim of this paper was to identify chondrocyte-specific genes by cDNA representational difference analysis (RDA) to use as markers in stem-cell-based chondrogenic tissue engineering. The project resulted in the identification and early characterisation of a novel chondrocyte-specific gene. …