Erschienen in:
01.10.2009 | Short Communication
Identification of candidate genes for susceptibility to reactive arthritis
verfasst von:
Markus Rihl, Christian Barthel, Andreas Klos, Reinhold E. Schmidt, Paul P. Tak, Henning Zeidler, Jens G. Kuipers
Erschienen in:
Rheumatology International
|
Ausgabe 12/2009
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Abstract
This study was undertaken to evaluate the gene expression profile in monocytes from three patients with reactive arthritis (ReA) in remission in order to identify candidate genes accounting for a potential susceptibility to ReA. Gene expression analyses revealed eight differentially expressed mRNA transcripts in monocytes of ReA patients. The major part of genes encoded cytokines, growth factors and chemokines. There was a remarkably high proportion of proangiogenic factors, in particular IP10, ENA-78, and IL-8 accounting for a genetically determined susceptibility to ReA at the host cell level.