The authors declare that they have no competing interests.
SM performed the experiments. AS participated in the design of the study and wrote the manuscript. JRK and PEL participated in the design of the study. HS-K participated in the design of the study and helped to draft the manuscript.
On the basis of their biological function, potential genetic candidates for susceptibility to rheumatoid arthritis can be postulated. IFNGR1, encoding the ligand-binding chain of the receptor for interferon gamma, IFNγR1, is one such gene because interferon gamma is involved in the pathogenesis of the disease. In the coding sequence of IFNGR1, two nucleotide positions have been described to be polymorphic in the Japanese population. We therefore investigated the association of those two IFNGR1 single nucleotide polymorphisms with rheumatoid arthritis in a case-control study in a central European population. Surprisingly, however, neither position was polymorphic in the 364 individuals examined, indicating that IFNGR1 does not contribute to susceptibility to rheumatoid arthritis, at least in Caucasians.
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- IFNGR1single nucleotide polymorphisms in rheumatoid arthritis
Joachim R Kalden
Peter E Lipsky
- BioMed Central
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