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Journal of Cancer Research and Clinical Oncology

Erschienen in:

23.05.2020 | Original Article – Cancer Research

IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer

verfasst von: Ana Paula Lombardi Pereira, Kleber Paiva Trugilo, Nádia Calvo Martins Okuyama, Michelle Mota Sena, José D’Oliveira Couto-filho, Maria Angelica Ehara Watanabe, Karen Brajão de Oliveira

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2020

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Abstract

Purpose

Interleukin-10 (IL-10) is an immunoregulatory cytokine and its cervical and serum concentrations have been associated with a poor prognosis of cervical cancer. The rs1800872 polymorphism (c.-592C>A) in the promotor region of the IL-10 gene affects the production and expression of IL-10 and thus is able to determine the immune response profile in the cervix. Therefore, the aim of this work is to state the association between IL-10 c.-592C>A polymorphism and cervical cancer.

Methods

Genomic DNA was extracted from patient’s peripheral blood and tumor biopsy. Socio-demographic, sexual behavior and reproductive characteristics data were collected using a questionnaire.

Results

Co-dominant model in logistic binary regression adjusted for confounders, showed that patients presenting with C/A genotype had 2.15 times more chances for developing cervical cancer (OR 2.15; CI_95% 1.02–4.56). The dominant model, C/A + A/A, was also independently associated with 2.71 times more chances for cervical cancer development when compared to control patients (OR 2.71; CI_95% 1.05–4.47).

Conclusion

Our study analyses show the association between cervical cancer and IL-10 c.-592C>A polymorphism, demonstrating that the allele A presence was independently associated with higher risks of cervical cancer development.

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Titel: IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer
verfasst von: Ana Paula Lombardi Pereira
Kleber Paiva Trugilo
Nádia Calvo Martins Okuyama
Michelle Mota Sena
José D’Oliveira Couto-filho
Maria Angelica Ehara Watanabe
Karen Brajão de Oliveira
Publikationsdatum: 23.05.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2020
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-020-03256-0

Springer Medizin

IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer