Erschienen in:
01.12.2001 | Paper Report
IL-12: a candidate autoimmunity susceptibility gene
verfasst von:
Anne Barton
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
Type 1 diabetes (insulin-dependent diabetes mellitus [IDDM]) is an autoimmune disease with both genetic and environmental susceptibility components. The major susceptibility component is the human leukocyte antigen complex (HLA) but an unknown number of, as yet, unidentified genes are also required to mediate susceptibility. The non-obese diabetic (NOD) mouse spontaneously develops IDDM and differs from non-susceptible strains in the IL12B gene. Which encodes the p40 subunit of the interleukin (IL)-12. IL-12 promotes differentiation of T cells to the Th1 subset, and it is this group of cells that are thought to be involved in cell-mediated immunity. In NOD mice, Th1 cells mediate progression to IDDM and administration of IL-12 to prediabetic NOD mice accelerates the onset of diabetes. …