Erschienen in:
01.12.2001 | Paper Report
IL-18 and arthritis
verfasst von:
Diane Marshall
Erschienen in:
Arthritis Research & Therapy
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Ausgabe 1/2000
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Excerpt
Interleukin (IL)-18, a member of the IL-1 family of proteins, has previously been shown to be present in the synovium of rheumatoid arthritis (RA) patients (see Additional information [1]). IL-18 has also been shown to be important in sustaining Th1 responses, in the production of IL-8 and macrophage inflammatory protein-1a production, and in increasing IFN-? and TNF-a production by RA synovial membrane cultures, acting synergistically with IL-12 and IL-15. To provide direct evidence for a role of IL-18 in inflammatory arthritis, the authors have compared the development of collagen-induced arthritis (CIA) in IL-18-/- mice and wild-type mice (DBA/1). …