Background
Methods
Database | Search query |
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MEDLINE | (“Dupuytren Contracture”[Mesh] OR dupuytren*[tiab] OR palmar fibromatos*[tiab]) AND (“Ultrasonography”[Mesh] OR “ultrasonography” [Subheading] OR “Tomography”[Mesh] OR ultraso*[tiab] OR “radiography” [Subheading] OR echograph*[tiab] OR radiograph*[tiab] OR tomograph*[tiab] OR sonograph*[tiab] OR CT [tiab] OR PET [tiab] OR MRI [tiab] OR imaging [tiab]) |
EMBASE | (‘dupuytren contracture’/exp. OR dupuytren*:ab,ti OR ‘palmar fibromatosis’:ab,ti) AND (‘echography’/exp. OR ‘radiodiagnosis’/exp. OR ultraso*:ab,ti OR echograph*:ab,ti OR radiograph*:ab,ti OR tomograph*:ab,ti OR sonograph*:ab,ti OR ct:ab,ti OR pet:ab,ti OR mri:ab,ti OR imaging:ab,ti) |
Round 1: Title + abstract | Round 2: Full-text |
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Inclusion criteria | Inclusion criterion |
- Patients with DD | Imaging (US/MRI/CT/PET) used for the |
- Imaging (US/MRI/CT/PET) | assessment of DD |
Exclusion criteria | Exclusion criteria |
- Language other than Dutch, English, German or French | - Ultrasonic therapy for DD |
- No original data | - Imaging for post-operative complications |
- No original data |
Results
Diagnosis
Study (year) | Study design | Level of evidence | Imaging modality | N | Clinical details | Outcome measures | Results | Additional value MRI | Additional value US |
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Juvenspan (2014) [18] | Case-report | 5 | US + MRI | 1 | 37-year-old female with a mass at the distal end of Guyon’s canal in the right hand | Diagnosis of swelling with unknown origin | No suspected diagnosis following imaging | No | No |
Mordus (2017) [19] | Case-report | 5 | US + MRI | 1 | 64-year-old man with left hand clumsiness and loss of muscle mass between 1st and 2nd rays | Diagnosis of unknown cause of symptoms | No suspected diagnosis following imaging | No | No |
Habash (2007) [20] | Case-report | 5 | MRI | 1 | 36-year-old man with a 2-year history of a steadily enlarging mass of the right volar forearm | Diagnosis of swelling with unknown origin | Suspected fibroplastic sarcoma following imaging | No | – |
Kraus (2012) [21] | Case-report | 5 | US + MRI | 1 | 7-year-old girl with swelling in the left palm (4th ray) | Diagnosis of swelling with unknown origin | Suspected ganglion cyst following imaging | No | No |
Spyropoulou (2016) [22] | Case-report | 5 | MRI | 1 | 10-year-old boy with a nodule and a contracture of the distal interphalangeal joint of the right little finger | Diagnosis of swelling with unknown origin | Suspected fibrous histiocytoma following imaging | No | – |
Germano (2016) [23] | Case-report | 5 | US | 1 | 71-year-old man with clinical signs of Ledderhose, Peyronie and suspected DD and long-term use of primidone for essential tremor | Confirmation of diagnosis | Suspected DD following imaging | – | Yes |
Abogamal (2016) [24] | Cross-sectional | 4 | US | 8 | Suspected DD patients in a larger study of 114 diabetic patients with or without hand-pain | Confirmation of diagnosis | Suspected DD following imaging | – | Yes |
Measurement of disease extent
Study (year) | Study design | Level of evidence | Imaging modality | N (hands) | Clinical details | Outcome measures | Results | Additional value MRI | Additional value US |
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English (2012) [25] | Case-report | 5 | MRI | 1 | 59-year-old woman with Ledderhose disease, knucklepads and DD. | Signal intensity, disease margins and depth | Detailed display of MRI signal intensity and demonstration of severity and depth of the different fibromatoses. | Yesa | – |
Yacoe (1993) [26] | Prospective case-series | 4 | MRI | 10 (11) | DD patients undergoing fasciectomy | Disease extent on MRI compared by surgery/histology | Accurate detection of 22/23 cords and 13/14 nodules prospectively. | Yes | – |
Measurement of disease activity
Author (year) | Study type | Level of evidence | Imaging modality | N (hands) | Clinical details | Outcome measures | Results | Additional value MRI | Additional value US |
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Ulusoy (2015) [27] | Case-report | 5 | US - (elastography) | 1 | 77-year-old male with bilateral contractures of thumb and little fingers. | Echogenicity, vascularity and elasticity. | Thickened palmar fascia with high vascularity and mixed echogenicity Differences in stiffness of DD tissue | – | Yesa |
Vanek (2018) [28] | Prospective cohort study | 3 | US | 38 | DD patients undergoing either PNF or CCH-injections. | - Nodularity + echogenicity of cords - 2-year follow-up for signs of residual disease (palpable cord or recurrent contracture) | Palpable cord: - fibrillar: 1/6, nodular: 14/32 Recurrent contracture: - fibrillar: 0/6, nodular: 3/32 | – | Yes |
Yacoe (1993) [26] | Prospective case-series. | 4 | MRI | 10 (11) | DD patients undergoing fasciectomy | - MRI signal intensity - Cellularity (histology) | - 22 cords and 3 nodules with low or low to intermediate signal intensity and hypo-cellularity - 10 nodules with intermediate signal and focal areas of high or low signal intensity and high cellularity or mixed composition | Yes |
Guidance of minimally invasive procedures
Author (year) | Study type | Level of evidence | Imaging modality | N (fingers) | Clinical details | Outcome parameters | Results | Additional value MRI | Additional value US |
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Elsahy (1976) [29] | Prospective case-series | 4 | Pre-operative US | unknown | DD patients undergoing fasciectomy. | Course of NV-bundles | Course of NV-bundle with US corresponded to surgical findings | – | Cannot be determined |
Uehara (2012) [30] | Case-control study | 4 | Pre-operative US | - DD patients: 14 (25) - Healthy volunteers: 22 | DD patients, of which 8 underwent fasciectomy, and healthy volunteers. | Sensitivity /specificity of detecting displaced NV-bundle | - Sensitivity/specificity: 80%/76% when difference in depth between ulnar and radial bundle> 3 mm - US-findings corresponded to surgical findings in operated cases. | – | Cannot be determined |
Sakellariou (2015) [31] | Prospective cohort study | 3 | Pre-operative US | 48 (90) | DD patients undergoing PNF | - Complications - Immediate correction of contracture - Recurrence at 26 months | - Complications: no tendon rupture or damage to NV-bundle - Correction: MCP 80% PIP 66% - Recurrence (requiring surgery): 18.2% | – | Cannot be determined |
Sampson(2011) [32] | Case-report | 5 | Peri-operativeUS | 1 | 64-year-old woman undergoing PNF and osteopathic manipulative treatment | - Complications’ - Correction of contracture | No complications. Full extension after 5th round of treatment. | – | Cannot be determined |
Leclère (2013) [33] | Prospective cohort study | 3 | Peri-operative US | 33 (43) | DD patients undergoing CCH injections | - complications - Correction of contracture: immediate and at 9.9 months - Subjective patient satisfaction - DASH-questionaire | - No tendon rupture or damage to NV-bundle - Immediate correction: MCP 90%, PIP 84% Correction at 9.9 months: MCP 77%, PIP 59% - Satisfaction: 81% - DASH-score: significant decrease during follow-up (P < 0.001) | – | Cannot be determined |
Croutzet (2017) [34]a | Prospective cohort study | 4 | Peri-operativeUS | (105) | DD patients undergoing minimally invasive procedure | Complications | No instance of tendon rupture or damage to NV-bundle | – | Cannot be determined |
Croutzet (2017) [35]a | Prospective cohort study | 4 | Peri-operativeUS | (12) | DD patients undergoing minimally invasive procedure | Hematoma | No instance of specific bleeding or hematoma. | – | Cannot be determined |
Evaluation of treatment
Study (year) | Design | Level of evidence | Imaging modality | N (hands) | Clinical details | Outcome parameters | Results | Additional value MRI | Additional value US |
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Christie (2011) [36] | Case-report | 5 | US | 1 (1) | A 42-year-old patient undergoing cross-frictional therapy (8 weeks) | - Visible changes: US + clinical examination - ROM - Symptoms (subjective) | - US: no observed subcutaneous changes - Clinical examination: decreased nodule size, skin wrinkling and contractile bands - Increased ROM - Reduced patient-reported symptoms | – | No |
Yin (2016) [37] | Prospective cohort study | 3 | US | 37 (49) | Dupuytren patients undergoing injection of triamcinolone acetonide in nodules. Follow-up: 5 years. | - Nodule size on US - Complications | - nodule size: reduction of 40% at 6 months and 56% at 5 years. - complications: none | – | Yes |
Banks (2017) [38] | Retrospective cohort study | 4 | MRI | 6 (8) | Patients with superficial fibromatoses of the hand and feet undergoing EBT Follow-up 4.5 months. | - Nodule volume on MRI - MRI signal intensity - Pain (VAS-score) | - Volume: significant decrease from 1.5 to 1.2 cm3 - Signal intensity: significant decrease - Pain: decrease in VAS-score in patients with high pre-treatment signal intensity | Yes | – |
Strömberg (2017) [39] | Prospective cohort study | 3 | US | 39 | 19 patients undergoing CCH, 20 patients undergoing PNF. Follow-up 1 year. | - Gap-width measured with US - Correction of MCP-joint - Recurrence | - Gap-width (median) 18 mm for both groups - MCP-correction (median): PNF 46° and CCH 53° - Recurrence: n = 1 | Yes | |
Crivello (2015) [40] | Prospective cohort study | 4 | MRI | 5 (5) | 5 DD patients undergoing CCH in 5 fingers. Follow-up 30 days. | - MRI signal intensity - Cord volume | - MRI signal intensity: significant increase (320%) - Cord volume: significant decrease (72%) | Yes |