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Erschienen in: Current Cardiovascular Imaging Reports 10/2015

01.10.2015 | Cardiac Magnetic Resonance (E Nagel and V Puntmann, Section Editors)

Imaging in Deciphering Histological Substrates in Hypertrophic Cardiomyopathy

verfasst von: Raquel Sukhbir, Rabah Alreshq, Nicholas Child

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 10/2015

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Abstract

Over the last 5 years, there has been great interest in how advanced imaging can be used in hypertrophic cardiomyopathy (HCM) to better understand the disease and improve patient diagnosis, monitoring and outcomes. The role of imaging has progressed beyond its initial purpose of simply identifying hypertrophic regions of myocardium, and now has the potential for in vivo tissue characterization reflecting the pathological histological underlying changes. This article aims to review the recent developments in advanced imaging and their potential clinical implications in HCM. The majority of these developments have occurred in the field of cardiac magnetic resonance (CMR) imaging, which is reflected in CMR forming a large proportion of the article, with other non-CMR techniques discussed in relation to these findings. Realizing the histological progression of HCM through advanced imaging has the potential to revolutionize diagnosis, management and future treatment.
Literatur
1.
Zurück zum Zitat Maron BJ, McKenna WJ, Danielson GK, et al. American College of Cardiology/European Society of Cardiology Clinical Expert Consensus Document on Hypertrophic Cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines. Eur Heart J. 2003;24:1965–91.PubMedCrossRef Maron BJ, McKenna WJ, Danielson GK, et al. American College of Cardiology/European Society of Cardiology Clinical Expert Consensus Document on Hypertrophic Cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines. Eur Heart J. 2003;24:1965–91.PubMedCrossRef
2.
Zurück zum Zitat Watkins H, Ashrafian H, Redwood C. Inherited cardiomyopathies. N Engl J Med. 2011;364:1643–56.PubMedCrossRef Watkins H, Ashrafian H, Redwood C. Inherited cardiomyopathies. N Engl J Med. 2011;364:1643–56.PubMedCrossRef
4.
Zurück zum Zitat Maron BJ, Gardin JM, Flack JM, et al. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation. 1995;92:785–9.PubMedCrossRef Maron BJ, Gardin JM, Flack JM, et al. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation. 1995;92:785–9.PubMedCrossRef
5.
Zurück zum Zitat Elliott PM, Anastasakis A, Borger MA, et al. 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J. 2014;35:2733–79.PubMedCrossRef Elliott PM, Anastasakis A, Borger MA, et al. 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J. 2014;35:2733–79.PubMedCrossRef
6.
Zurück zum Zitat Olivotto I, Cecchi F, Poggesi C, et al. Patterns of disease progression in hypertrophic cardiomyopathy: an individualized approach to clinical staging. Circulat Heart Fail. 2012;5:535–46.CrossRef Olivotto I, Cecchi F, Poggesi C, et al. Patterns of disease progression in hypertrophic cardiomyopathy: an individualized approach to clinical staging. Circulat Heart Fail. 2012;5:535–46.CrossRef
7.
Zurück zum Zitat Maron BJ, Ommen SR, Semsarian C, et al. Hypertrophic cardiomyopathy: present and future, with translation into contemporary cardiovascular medicine. J Am Coll Cardiol. 2014;64:83–99.PubMedCrossRef Maron BJ, Ommen SR, Semsarian C, et al. Hypertrophic cardiomyopathy: present and future, with translation into contemporary cardiovascular medicine. J Am Coll Cardiol. 2014;64:83–99.PubMedCrossRef
8.
Zurück zum Zitat Bogun FM, Desjardins B, Good E, et al. Delayed-enhanced magnetic resonance imaging in nonischemic cardiomyopathy: utility for identifying the ventricular arrhythmia substrate. J Am Coll Cardiol. 2009;53:1138–45.PubMedCentralPubMedCrossRef Bogun FM, Desjardins B, Good E, et al. Delayed-enhanced magnetic resonance imaging in nonischemic cardiomyopathy: utility for identifying the ventricular arrhythmia substrate. J Am Coll Cardiol. 2009;53:1138–45.PubMedCentralPubMedCrossRef
9.••
Zurück zum Zitat Elliott P, McKenna WJ. Hypertrophic cardiomyopathy. Lancet. 2004;363:1881–91. Important overview of HCM. PubMedCrossRef Elliott P, McKenna WJ. Hypertrophic cardiomyopathy. Lancet. 2004;363:1881–91. Important overview of HCM. PubMedCrossRef
11.
Zurück zum Zitat Olivotto I, d’Amati G, Basso C, et al. Defining phenotypes and disease progression in sarcomeric cardiomyopathies: contemporary role of clinical investigations. Cardiovasc Res. 2015;105:409–23.PubMedCrossRef Olivotto I, d’Amati G, Basso C, et al. Defining phenotypes and disease progression in sarcomeric cardiomyopathies: contemporary role of clinical investigations. Cardiovasc Res. 2015;105:409–23.PubMedCrossRef
12.
Zurück zum Zitat Rickers C, Wilke NM, Jerosch-Herold M, et al. Utility of cardiac magnetic resonance imaging in the diagnosis of hypertrophic cardiomyopathy. Circulation. 2005;112:855–61.PubMedCrossRef Rickers C, Wilke NM, Jerosch-Herold M, et al. Utility of cardiac magnetic resonance imaging in the diagnosis of hypertrophic cardiomyopathy. Circulation. 2005;112:855–61.PubMedCrossRef
13.
Zurück zum Zitat Hasenfuss G. Sarcomeric cardiomyopathies: from bedside to bench and back. Cardiovasc Res. 2015;105:395–6.PubMedCrossRef Hasenfuss G. Sarcomeric cardiomyopathies: from bedside to bench and back. Cardiovasc Res. 2015;105:395–6.PubMedCrossRef
14.
Zurück zum Zitat Pattanayak P, Bleumke DA. Tissue characterization of the myocardium: state of the art characterization by magnetic resonance and computed tomography imaging. Radiol Clin North Am. 2015;53:413–23.PubMedCrossRef Pattanayak P, Bleumke DA. Tissue characterization of the myocardium: state of the art characterization by magnetic resonance and computed tomography imaging. Radiol Clin North Am. 2015;53:413–23.PubMedCrossRef
15.
Zurück zum Zitat Shirani J, Pick R, Roberts WC, et al. Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death. J Am Coll Cardiol. 2000;35:36–44.PubMedCrossRef Shirani J, Pick R, Roberts WC, et al. Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death. J Am Coll Cardiol. 2000;35:36–44.PubMedCrossRef
16.
Zurück zum Zitat Ho CY, Lopez B, Coelho-Filho OR, et al. Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy. N Engl J Med. 2010;363:552–63.PubMedCentralPubMedCrossRef Ho CY, Lopez B, Coelho-Filho OR, et al. Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy. N Engl J Med. 2010;363:552–63.PubMedCentralPubMedCrossRef
17.
Zurück zum Zitat Basso C, Thiene G, Corrado D, et al. Hypertrophic cardiomyopathy and sudden death in the young: pathologic evidence of myocardial ischemia. Hum Pathol. 2000;31:988–98.PubMedCrossRef Basso C, Thiene G, Corrado D, et al. Hypertrophic cardiomyopathy and sudden death in the young: pathologic evidence of myocardial ischemia. Hum Pathol. 2000;31:988–98.PubMedCrossRef
18.
Zurück zum Zitat Croisille P, Revel D, Saeed M. Contrast agents and cardiac MR imaging of myocardial ischemia: from bench to bedside. Eur Radiol. 2006;16:1951–63.PubMedCrossRef Croisille P, Revel D, Saeed M. Contrast agents and cardiac MR imaging of myocardial ischemia: from bench to bedside. Eur Radiol. 2006;16:1951–63.PubMedCrossRef
19.
Zurück zum Zitat Wesbey GE, Higgins CB, McNamara MT, et al. Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium. Radiology. 1984;153:165–9.PubMedCrossRef Wesbey GE, Higgins CB, McNamara MT, et al. Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium. Radiology. 1984;153:165–9.PubMedCrossRef
20.
Zurück zum Zitat Lehrke S, Lossnitzer D, Schob M, et al. Use of cardiovascular magnetic resonance for risk stratification in chronic heart failure: prognostic value of late gadolinium enhancement in patients with non-ischaemic dilated cardiomyopathy. Heart. 2011;97:727–32.PubMedCrossRef Lehrke S, Lossnitzer D, Schob M, et al. Use of cardiovascular magnetic resonance for risk stratification in chronic heart failure: prognostic value of late gadolinium enhancement in patients with non-ischaemic dilated cardiomyopathy. Heart. 2011;97:727–32.PubMedCrossRef
21.
Zurück zum Zitat Yokota H, Imai Y, Tsuboko Y, et al. Nocturnal blood pressure pattern affects left ventricular remodeling and late gadolinium enhancement in patients with hypertension and left ventricular hypertrophy. PLoS One. 2013;8:e67825.PubMedCentralPubMedCrossRef Yokota H, Imai Y, Tsuboko Y, et al. Nocturnal blood pressure pattern affects left ventricular remodeling and late gadolinium enhancement in patients with hypertension and left ventricular hypertrophy. PLoS One. 2013;8:e67825.PubMedCentralPubMedCrossRef
22.
Zurück zum Zitat Nagai T, Kohsaka S, Okuda S, et al. Incidence and prognostic significance of myocardial late gadolinium enhancement in patients with sarcoidosis without cardiac manifestation. Chest. 2014;146:1064–72.PubMedCrossRef Nagai T, Kohsaka S, Okuda S, et al. Incidence and prognostic significance of myocardial late gadolinium enhancement in patients with sarcoidosis without cardiac manifestation. Chest. 2014;146:1064–72.PubMedCrossRef
23.
Zurück zum Zitat Radunski UK, Lund GK, Stehning C, et al. CMR in patients with severe myocarditis: diagnostic value of quantitative tissue markers including extracellular volume imaging. J Am Coll Cardiol Img. 2014;7:667–75.CrossRef Radunski UK, Lund GK, Stehning C, et al. CMR in patients with severe myocarditis: diagnostic value of quantitative tissue markers including extracellular volume imaging. J Am Coll Cardiol Img. 2014;7:667–75.CrossRef
24.
Zurück zum Zitat Kwon DH, Smedira NG, Rodriguez ER, et al. Cardiac magnetic resonance detection of myocardial scarring in hypertrophic cardiomyopathy: correlation with histopathology and prevalence of ventricular tachycardia. J Am Coll Cardiol. 2009;54:242–9.PubMedCrossRef Kwon DH, Smedira NG, Rodriguez ER, et al. Cardiac magnetic resonance detection of myocardial scarring in hypertrophic cardiomyopathy: correlation with histopathology and prevalence of ventricular tachycardia. J Am Coll Cardiol. 2009;54:242–9.PubMedCrossRef
25.
Zurück zum Zitat Simonetti OP, Kim RJ, Fieno DS, et al. An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001;218:215–23.PubMedCrossRef Simonetti OP, Kim RJ, Fieno DS, et al. An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001;218:215–23.PubMedCrossRef
26.
Zurück zum Zitat Moravsky G, Ofek E, Rakowski H, et al. Myocardial fibrosis in hypertrophic cardiomyopathy: accurate reflection of histopathological findings by CMR. J Am Coll Cardiol Img. 2013;6:587–96.CrossRef Moravsky G, Ofek E, Rakowski H, et al. Myocardial fibrosis in hypertrophic cardiomyopathy: accurate reflection of histopathological findings by CMR. J Am Coll Cardiol Img. 2013;6:587–96.CrossRef
27.
Zurück zum Zitat Funada A, Kanzaki H, Noguchi T, et al. Prognostic significance of late gadolinium enhancement quantification in cardiac magnetic resonance imaging of hypertrophic cardiomyopathy with systolic dysfunction. Heart Vessels 2015. Funada A, Kanzaki H, Noguchi T, et al. Prognostic significance of late gadolinium enhancement quantification in cardiac magnetic resonance imaging of hypertrophic cardiomyopathy with systolic dysfunction. Heart Vessels 2015.
28.
Zurück zum Zitat Appelbaum E, Maron BJ, Adabag S, et al. Intermediate-signal-intensity late gadolinium enhancement predicts ventricular tachyarrhythmias in patients with hypertrophic cardiomyopathy. Circulat Cardiovasc Imag. 2012;5:78–85.CrossRef Appelbaum E, Maron BJ, Adabag S, et al. Intermediate-signal-intensity late gadolinium enhancement predicts ventricular tachyarrhythmias in patients with hypertrophic cardiomyopathy. Circulat Cardiovasc Imag. 2012;5:78–85.CrossRef
29.
Zurück zum Zitat Choudhury L, Mahrholdt H, Wagner A, et al. Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2002;40:2156–64.PubMedCrossRef Choudhury L, Mahrholdt H, Wagner A, et al. Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2002;40:2156–64.PubMedCrossRef
30.
Zurück zum Zitat Teraoka K, Hirano M, Ookubo H, et al. Delayed contrast enhancement of MRI in hypertrophic cardiomyopathy. Magn Reson Imaging. 2004;22:155–61.PubMedCrossRef Teraoka K, Hirano M, Ookubo H, et al. Delayed contrast enhancement of MRI in hypertrophic cardiomyopathy. Magn Reson Imaging. 2004;22:155–61.PubMedCrossRef
31.
Zurück zum Zitat Kwon DH, Setser RM, Popovic ZB, et al. Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study. Int J Cardiovasc Imag. 2008;24:617–25.CrossRef Kwon DH, Setser RM, Popovic ZB, et al. Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study. Int J Cardiovasc Imag. 2008;24:617–25.CrossRef
32.
Zurück zum Zitat Moon JC, McKenna WJ, McCrohon JA, et al. Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol. 2003;41:1561–7.PubMedCrossRef Moon JC, McKenna WJ, McCrohon JA, et al. Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol. 2003;41:1561–7.PubMedCrossRef
33.
Zurück zum Zitat O’Hanlon R, Grasso A, Roughton M, et al. Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2010;56:867–74.PubMedCrossRef O’Hanlon R, Grasso A, Roughton M, et al. Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2010;56:867–74.PubMedCrossRef
34.
Zurück zum Zitat Bruder O, Wagner A, Jensen CJ, et al. Myocardial scar visualized by cardiovascular magnetic resonance imaging predicts major adverse events in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2010;56:875–87.PubMedCrossRef Bruder O, Wagner A, Jensen CJ, et al. Myocardial scar visualized by cardiovascular magnetic resonance imaging predicts major adverse events in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2010;56:875–87.PubMedCrossRef
35.
Zurück zum Zitat Maron MS, Appelbaum E, Harrigan CJ, et al. Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy. Circulat Heart Fail. 2008;1:184–91.CrossRef Maron MS, Appelbaum E, Harrigan CJ, et al. Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy. Circulat Heart Fail. 2008;1:184–91.CrossRef
36.••
Zurück zum Zitat Green JJ, Berger JS, Kramer CM, et al. Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy. J Am Coll Cardiol Img. 2012;5:370–7. Important LGE meta-analysis. CrossRef Green JJ, Berger JS, Kramer CM, et al. Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy. J Am Coll Cardiol Img. 2012;5:370–7. Important LGE meta-analysis. CrossRef
37.
Zurück zum Zitat Rubinshtein R, Glockner JF, Ommen SR, et al. Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic cardiomyopathy. Circulat Heart Fail. 2010;3:51–8.CrossRef Rubinshtein R, Glockner JF, Ommen SR, et al. Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic cardiomyopathy. Circulat Heart Fail. 2010;3:51–8.CrossRef
38.
Zurück zum Zitat Hen Y, Iguchi N, Utanohara Y, et al. Prognostic value of late gadolinium enhancement on cardiac magnetic resonance imaging in Japanese hypertrophic cardiomyopathy patients. Circulat J : Off J Jap Circulat Soc. 2014;78:929–37.CrossRef Hen Y, Iguchi N, Utanohara Y, et al. Prognostic value of late gadolinium enhancement on cardiac magnetic resonance imaging in Japanese hypertrophic cardiomyopathy patients. Circulat J : Off J Jap Circulat Soc. 2014;78:929–37.CrossRef
39.
Zurück zum Zitat Hanneman K, Crean AM, Williams L, et al. Cardiac magnetic resonance imaging findings predict major adverse events in apical hypertrophic cardiomyopathy. J Thorac Imaging. 2014;29:331–9.PubMedCrossRef Hanneman K, Crean AM, Williams L, et al. Cardiac magnetic resonance imaging findings predict major adverse events in apical hypertrophic cardiomyopathy. J Thorac Imaging. 2014;29:331–9.PubMedCrossRef
40.••
Zurück zum Zitat Dawson DK, Hawlisch K, Prescott G, et al. Prognostic role of CMR in patients presenting with ventricular arrhythmias. J Am Coll Cardiol Img. 2013;6:335–44. Important LGE risk analysis. CrossRef Dawson DK, Hawlisch K, Prescott G, et al. Prognostic role of CMR in patients presenting with ventricular arrhythmias. J Am Coll Cardiol Img. 2013;6:335–44. Important LGE risk analysis. CrossRef
41.
Zurück zum Zitat Chan W, Duffy SJ, White DA, et al. Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion. J Am Coll Cardiol Img. 2012;5:884–93.CrossRef Chan W, Duffy SJ, White DA, et al. Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion. J Am Coll Cardiol Img. 2012;5:884–93.CrossRef
42.
Zurück zum Zitat Prinz C, Schwarz M, Ilic I, et al. Myocardial fibrosis severity on cardiac magnetic resonance imaging predicts sustained arrhythmic events in hypertrophic cardiomyopathy. Can J Cardiol. 2013;29:358–63.PubMedCrossRef Prinz C, Schwarz M, Ilic I, et al. Myocardial fibrosis severity on cardiac magnetic resonance imaging predicts sustained arrhythmic events in hypertrophic cardiomyopathy. Can J Cardiol. 2013;29:358–63.PubMedCrossRef
43.
Zurück zum Zitat Kwon DH, Halley CM, Carrigan TP, et al. Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study. J Am Coll Cardiol Img. 2009;2:34–44.CrossRef Kwon DH, Halley CM, Carrigan TP, et al. Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study. J Am Coll Cardiol Img. 2009;2:34–44.CrossRef
44.
Zurück zum Zitat Fujita T, Konno T, Yokawa J, et al. Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias. J Cardiol 2014. Fujita T, Konno T, Yokawa J, et al. Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias. J Cardiol 2014.
45.
Zurück zum Zitat Sakamoto N, Sato N, Oikawa K, et al. Late gadolinium enhancement of cardiac magnetic resonance imaging indicates abnormalities of time-domain T-wave alternans in hypertrophic cardiomyopathy with ventricular tachycardia. Heart Rhythm : Off J Heart Rhythm Society 2015. Sakamoto N, Sato N, Oikawa K, et al. Late gadolinium enhancement of cardiac magnetic resonance imaging indicates abnormalities of time-domain T-wave alternans in hypertrophic cardiomyopathy with ventricular tachycardia. Heart Rhythm : Off J Heart Rhythm Society 2015.
46.••
Zurück zum Zitat Sakamoto N, Kawamura Y, Sato N, et al. Late gadolinium enhancement on cardiac magnetic resonance represents the depolarizing and repolarizing electrically damaged foci causing malignant ventricular arrhythmia in hypertrophic cardiomyopathy. Heart rhythm : Off J Heart Rhythm Soc. 2015;12:1276–84. Important and recent relationship between LGE and endocardial scar and location of arrhythmias. CrossRef Sakamoto N, Kawamura Y, Sato N, et al. Late gadolinium enhancement on cardiac magnetic resonance represents the depolarizing and repolarizing electrically damaged foci causing malignant ventricular arrhythmia in hypertrophic cardiomyopathy. Heart rhythm : Off J Heart Rhythm Soc. 2015;12:1276–84. Important and recent relationship between LGE and endocardial scar and location of arrhythmias. CrossRef
47.
Zurück zum Zitat Chan RH, Maron BJ, Olivotto I, et al. Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy. Circulation. 2014;130:484–95.PubMedCrossRef Chan RH, Maron BJ, Olivotto I, et al. Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy. Circulation. 2014;130:484–95.PubMedCrossRef
48.
Zurück zum Zitat Gersh BJ, Maron BJ, Bonow RO, et al. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2011;58:e212–60.PubMedCrossRef Gersh BJ, Maron BJ, Bonow RO, et al. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2011;58:e212–60.PubMedCrossRef
49.
Zurück zum Zitat Choi HM, Kim KH, Lee JM, et al. Myocardial fibrosis progression on cardiac magnetic resonance in hypertrophic cardiomyopathy. Heart. 2015;101:870–6.PubMedCrossRef Choi HM, Kim KH, Lee JM, et al. Myocardial fibrosis progression on cardiac magnetic resonance in hypertrophic cardiomyopathy. Heart. 2015;101:870–6.PubMedCrossRef
50.
Zurück zum Zitat Shimada YJ, Passeri JJ, Baggish AL, et al. Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail. 2013;1:480–7.PubMedCentralPubMedCrossRef Shimada YJ, Passeri JJ, Baggish AL, et al. Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail. 2013;1:480–7.PubMedCentralPubMedCrossRef
51.
Zurück zum Zitat Lardo AC, Cordeiro MA, Silva C, et al. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation. 2006;113:394–404.PubMedCentralPubMedCrossRef Lardo AC, Cordeiro MA, Silva C, et al. Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation. 2006;113:394–404.PubMedCentralPubMedCrossRef
52.
Zurück zum Zitat Bettencourt N, Ferreira ND, Leite D, et al. CAD detection in patients with intermediate-high pre-test probability: low-dose CT delayed enhancement detects ischemic myocardial scar with moderate accuracy but does not improve performance of a stress-rest CT perfusion protocol. J Am Coll Cardiol Img. 2013;6:1062–71.CrossRef Bettencourt N, Ferreira ND, Leite D, et al. CAD detection in patients with intermediate-high pre-test probability: low-dose CT delayed enhancement detects ischemic myocardial scar with moderate accuracy but does not improve performance of a stress-rest CT perfusion protocol. J Am Coll Cardiol Img. 2013;6:1062–71.CrossRef
53.
Zurück zum Zitat Lessick J, Abadi S, Agmon Y, et al. Multidetector computed tomography predictors of late ventricular remodeling and function after acute myocardial infarction. Eur J Radiol. 2012;81:2648–57.PubMedCrossRef Lessick J, Abadi S, Agmon Y, et al. Multidetector computed tomography predictors of late ventricular remodeling and function after acute myocardial infarction. Eur J Radiol. 2012;81:2648–57.PubMedCrossRef
54.
Zurück zum Zitat Shiozaki AA, Santos TS, Artega E, et al. Images in cardiovascular medicine. Myocardial delayed enhancement by computed tomography in hypertrophic cardiomyopathy. Circulation. 2007;115:e430–1.PubMedCrossRef Shiozaki AA, Santos TS, Artega E, et al. Images in cardiovascular medicine. Myocardial delayed enhancement by computed tomography in hypertrophic cardiomyopathy. Circulation. 2007;115:e430–1.PubMedCrossRef
55.
Zurück zum Zitat Berliner JI, Kino A, Carr JC, et al. Cardiac computed tomographic imaging to evaluate myocardial scarring/fibrosis in patients with hypertrophic cardiomyopathy: a comparison with cardiac magnetic resonance imaging. Int J Cardiovasc Imag. 2013;29:191–7.CrossRef Berliner JI, Kino A, Carr JC, et al. Cardiac computed tomographic imaging to evaluate myocardial scarring/fibrosis in patients with hypertrophic cardiomyopathy: a comparison with cardiac magnetic resonance imaging. Int J Cardiovasc Imag. 2013;29:191–7.CrossRef
56.
Zurück zum Zitat Langer C, Lutz M, Eden M, et al. Hypertrophic cardiomyopathy in cardiac CT: a validation study on the detection of intramyocardial fibrosis in consecutive patients. Int J Cardiovasc Imag. 2014;30:659–67.CrossRef Langer C, Lutz M, Eden M, et al. Hypertrophic cardiomyopathy in cardiac CT: a validation study on the detection of intramyocardial fibrosis in consecutive patients. Int J Cardiovasc Imag. 2014;30:659–67.CrossRef
57.
Zurück zum Zitat Shiozaki AA, Senra T, Arteaga E, et al. Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy. J Cardiovasc Comput Tomograp. 2013;7:173–81.CrossRef Shiozaki AA, Senra T, Arteaga E, et al. Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy. J Cardiovasc Comput Tomograp. 2013;7:173–81.CrossRef
58.
Zurück zum Zitat Serri K, Reant P, Lafitte M, et al. Global and regional myocardial function quantification by two-dimensional strain: application in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2006;47:1175–81.PubMedCrossRef Serri K, Reant P, Lafitte M, et al. Global and regional myocardial function quantification by two-dimensional strain: application in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2006;47:1175–81.PubMedCrossRef
59.
Zurück zum Zitat Popovic ZB, Kwon DH, Mishra M, et al. Association between regional ventricular function and myocardial fibrosis in hypertrophic cardiomyopathy assessed by speckle tracking echocardiography and delayed hyperenhancement magnetic resonance imaging. J Am Soc Echocardiogr. 2008;21:1299–305.PubMedCrossRef Popovic ZB, Kwon DH, Mishra M, et al. Association between regional ventricular function and myocardial fibrosis in hypertrophic cardiomyopathy assessed by speckle tracking echocardiography and delayed hyperenhancement magnetic resonance imaging. J Am Soc Echocardiogr. 2008;21:1299–305.PubMedCrossRef
60.
Zurück zum Zitat Saito M, Okayama H, Yoshii T, et al. Clinical significance of global two-dimensional strain as a surrogate parameter of myocardial fibrosis and cardiac events in patients with hypertrophic cardiomyopathy. Europ Heart J Cardiovasc Imag. 2012;13:617–23.CrossRef Saito M, Okayama H, Yoshii T, et al. Clinical significance of global two-dimensional strain as a surrogate parameter of myocardial fibrosis and cardiac events in patients with hypertrophic cardiomyopathy. Europ Heart J Cardiovasc Imag. 2012;13:617–23.CrossRef
61.
Zurück zum Zitat Di Salvo G, Pacileo G, Limongelli G, et al. Non sustained ventricular tachycardia in hypertrophic cardiomyopathy and new ultrasonic derived parameters. J Am Soc Echocardiogr. 2010;23:581–90.PubMedCrossRef Di Salvo G, Pacileo G, Limongelli G, et al. Non sustained ventricular tachycardia in hypertrophic cardiomyopathy and new ultrasonic derived parameters. J Am Soc Echocardiogr. 2010;23:581–90.PubMedCrossRef
62.
Zurück zum Zitat Amano Y, Kumita S, Takayama M, et al. Comparison of contrast-enhanced MRI with iodine-123 BMIPP for detection of myocardial damage in hypertrophic cardiomyopathy. AJR Am J Roentgenol. 2005;185:312–8.PubMedCrossRef Amano Y, Kumita S, Takayama M, et al. Comparison of contrast-enhanced MRI with iodine-123 BMIPP for detection of myocardial damage in hypertrophic cardiomyopathy. AJR Am J Roentgenol. 2005;185:312–8.PubMedCrossRef
63.
Zurück zum Zitat Kuusisto J, Karja V, Sipola P, et al. Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy. Heart. 2012;98:1007–13.PubMedCentralPubMedCrossRef Kuusisto J, Karja V, Sipola P, et al. Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy. Heart. 2012;98:1007–13.PubMedCentralPubMedCrossRef
64.
Zurück zum Zitat Abdel-Aty H, Cocker M, Strohm O, et al. Abnormalities in T2-weighted cardiovascular magnetic resonance images of hypertrophic cardiomyopathy: regional distribution and relation to late gadolinium enhancement and severity of hypertrophy. J Magn Reson Imaging. 2008;28:242–5.PubMedCrossRef Abdel-Aty H, Cocker M, Strohm O, et al. Abnormalities in T2-weighted cardiovascular magnetic resonance images of hypertrophic cardiomyopathy: regional distribution and relation to late gadolinium enhancement and severity of hypertrophy. J Magn Reson Imaging. 2008;28:242–5.PubMedCrossRef
65.
Zurück zum Zitat Hen Y, Iguchi N, Machida H, et al. High signal intensity on T2-weighted cardiac magnetic resonance imaging correlates with the ventricular tachyarrhythmia in hypertrophic cardiomyopathy. Heart Vessel. 2013;28:742–9.CrossRef Hen Y, Iguchi N, Machida H, et al. High signal intensity on T2-weighted cardiac magnetic resonance imaging correlates with the ventricular tachyarrhythmia in hypertrophic cardiomyopathy. Heart Vessel. 2013;28:742–9.CrossRef
66.
Zurück zum Zitat Todiere G, Pisciella L, Barison A, et al. Abnormal T2-STIR magnetic resonance in hypertrophic cardiomyopathy: a marker of advanced disease and electrical myocardial instability. PLoS One. 2014;9:e111366.PubMedCentralPubMedCrossRef Todiere G, Pisciella L, Barison A, et al. Abnormal T2-STIR magnetic resonance in hypertrophic cardiomyopathy: a marker of advanced disease and electrical myocardial instability. PLoS One. 2014;9:e111366.PubMedCentralPubMedCrossRef
67.
Zurück zum Zitat Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation. 1991;83:1849–65.PubMedCrossRef Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation. 1991;83:1849–65.PubMedCrossRef
68.
Zurück zum Zitat Bhuva AN, Treibel TA, Fontana M, et al. T1 mapping: non-invasive evaluation of myocardial tissue composition by cardiovascular magnetic resonance. Expert Rev Cardiovasc Ther. 2014;12:1455–64.PubMedCrossRef Bhuva AN, Treibel TA, Fontana M, et al. T1 mapping: non-invasive evaluation of myocardial tissue composition by cardiovascular magnetic resonance. Expert Rev Cardiovasc Ther. 2014;12:1455–64.PubMedCrossRef
69.
Zurück zum Zitat Caspari PG, Gibson K, Harris P. Changes in myocardial collagen in normal development and after beta blockade. Rec Adv Stud Cardiac Struct Metab. 1975;7:99–104. Caspari PG, Gibson K, Harris P. Changes in myocardial collagen in normal development and after beta blockade. Rec Adv Stud Cardiac Struct Metab. 1975;7:99–104.
70.
Zurück zum Zitat Fang L, Beale A, Ellims AH, et al. Associations between fibrocytes and postcontrast myocardial T1 times in hypertrophic cardiomyopathy. J Am Heart Assoc. 2013;2:e000270.PubMedCentralPubMedCrossRef Fang L, Beale A, Ellims AH, et al. Associations between fibrocytes and postcontrast myocardial T1 times in hypertrophic cardiomyopathy. J Am Heart Assoc. 2013;2:e000270.PubMedCentralPubMedCrossRef
71.
Zurück zum Zitat Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators. N Engl J Med. 1999;341:709–17.PubMedCrossRef Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators. N Engl J Med. 1999;341:709–17.PubMedCrossRef
72.
Zurück zum Zitat Zannad F, Alla F, Dousset B, et al. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investig Circulat. 2000;102:2700–6.CrossRef Zannad F, Alla F, Dousset B, et al. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investig Circulat. 2000;102:2700–6.CrossRef
73.
Zurück zum Zitat Nagel E, Narula J. Evolution and revolution in CMR imaging. J Am Coll Cardiol Img. 2013;6:837–8.CrossRef Nagel E, Narula J. Evolution and revolution in CMR imaging. J Am Coll Cardiol Img. 2013;6:837–8.CrossRef
74.
Zurück zum Zitat Treibel TA, White SK, Moon JC. Myocardial tissue characterization: histological and pathophysiological correlation. Curr Cardiovasc Imag Rep. 2014;7:9254.CrossRef Treibel TA, White SK, Moon JC. Myocardial tissue characterization: histological and pathophysiological correlation. Curr Cardiovasc Imag Rep. 2014;7:9254.CrossRef
75.••
Zurück zum Zitat Moon JC, Messroghli DR, Kellman P, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2013;15:92. Overview of the use of T1 mapping. CrossRef Moon JC, Messroghli DR, Kellman P, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2013;15:92. Overview of the use of T1 mapping. CrossRef
76.
Zurück zum Zitat Liu S, Han J, Nacif MS, et al. Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2012;14:90.CrossRef Liu S, Han J, Nacif MS, et al. Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2012;14:90.CrossRef
77.
Zurück zum Zitat Hwang SH, Advanced CBW, Cardiac MR. Imaging for myocardial characterization and quantification: T1 mapping. Korean Circulat J. 2013;43:1–6.CrossRef Hwang SH, Advanced CBW, Cardiac MR. Imaging for myocardial characterization and quantification: T1 mapping. Korean Circulat J. 2013;43:1–6.CrossRef
78.••
Zurück zum Zitat Rogers T, Dabir D, Mahmoud I, et al. Standardization of T1 measurements with MOLLI in differentiation between health and disease--the ConSept study. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2013;15:78. The use of clinical T1 mapping. CrossRef Rogers T, Dabir D, Mahmoud I, et al. Standardization of T1 measurements with MOLLI in differentiation between health and disease--the ConSept study. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2013;15:78. The use of clinical T1 mapping. CrossRef
79.
Zurück zum Zitat Messroghli DR, Radjenovic A, Kozerke S, et al. Modified look-locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med. 2004;52:141–6.PubMedCrossRef Messroghli DR, Radjenovic A, Kozerke S, et al. Modified look-locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med. 2004;52:141–6.PubMedCrossRef
80.
Zurück zum Zitat Piechnik SK, Ferreira VM, Dall’Armellina E, et al. Shortened modified look-locker inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2010;12:69.CrossRef Piechnik SK, Ferreira VM, Dall’Armellina E, et al. Shortened modified look-locker inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2010;12:69.CrossRef
81.
Zurück zum Zitat DM H, JC M. Review of T1 mapping methods: comparative effectiveness including reproducibility issues. Curr Cardiovasc Imag Rep. 2014;7:9252.CrossRef DM H, JC M. Review of T1 mapping methods: comparative effectiveness including reproducibility issues. Curr Cardiovasc Imag Rep. 2014;7:9252.CrossRef
82.
Zurück zum Zitat Dabir D, Child N, Kalra A. Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2014;16:69.CrossRef Dabir D, Child N, Kalra A. Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2014;16:69.CrossRef
83.
Zurück zum Zitat Messroghli DR, Greiser A, Frohlich M, et al. Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart. J Magn Reson Imaging. 2007;26:1081–6.PubMedCrossRef Messroghli DR, Greiser A, Frohlich M, et al. Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart. J Magn Reson Imaging. 2007;26:1081–6.PubMedCrossRef
84.
Zurück zum Zitat Kehr E, Sono M, Chugh SS, et al. Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro. Int J Cardiovasc Imag. 2008;24:61–8.CrossRef Kehr E, Sono M, Chugh SS, et al. Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro. Int J Cardiovasc Imag. 2008;24:61–8.CrossRef
85.
Zurück zum Zitat Messroghli DR, Niendorf T, Schulz-Menger J, et al. T1 mapping in patients with acute myocardial infarction. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2003;5:353–9.CrossRef Messroghli DR, Niendorf T, Schulz-Menger J, et al. T1 mapping in patients with acute myocardial infarction. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2003;5:353–9.CrossRef
86.••
Zurück zum Zitat Puntmann VO, Voigt T, Chen Z, et al. Native T1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy. J Am Coll Cardiol Img. 2013;6:475–84. The use of T1 in HCM. CrossRef Puntmann VO, Voigt T, Chen Z, et al. Native T1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy. J Am Coll Cardiol Img. 2013;6:475–84. The use of T1 in HCM. CrossRef
87.
Zurück zum Zitat Wong TC, Piehler K, Meier CG, et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012;126:1206–16.PubMedCentralPubMedCrossRef Wong TC, Piehler K, Meier CG, et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012;126:1206–16.PubMedCentralPubMedCrossRef
88.
Zurück zum Zitat Dass S, Suttie JJ, Piechnik SK, et al. Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy. Circulat Cardiovasc Imag. 2012;5:726–33.CrossRef Dass S, Suttie JJ, Piechnik SK, et al. Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy. Circulat Cardiovasc Imag. 2012;5:726–33.CrossRef
89.
Zurück zum Zitat Kachenoura N, Besson-Hajji L, Graves MJ, et al. Kinetic index combining native and postcontrast myocardial T1 in hypertrophic cardiomyopathy. J Magn Reson Imaging 2015. Kachenoura N, Besson-Hajji L, Graves MJ, et al. Kinetic index combining native and postcontrast myocardial T1 in hypertrophic cardiomyopathy. J Magn Reson Imaging 2015.
90.
Zurück zum Zitat Ellims AH, Iles LM, Ling LH, et al. A comprehensive evaluation of myocardial fibrosis in hypertrophic cardiomyopathy with cardiac magnetic resonance imaging: linking genotype with fibrotic phenotype. Europ Heart J Cardiovasc Imag. 2014;15:1108–16.CrossRef Ellims AH, Iles LM, Ling LH, et al. A comprehensive evaluation of myocardial fibrosis in hypertrophic cardiomyopathy with cardiac magnetic resonance imaging: linking genotype with fibrotic phenotype. Europ Heart J Cardiovasc Imag. 2014;15:1108–16.CrossRef
91.
Zurück zum Zitat Flett AS, Hayward MP, Ashworth MT, et al. Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation. 2010;122:138–44.PubMedCrossRef Flett AS, Hayward MP, Ashworth MT, et al. Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation. 2010;122:138–44.PubMedCrossRef
92.
Zurück zum Zitat Ho CY, Abbasi SA, Neilan TG, et al. T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy. Circulat Cardiovasc Imag. 2013;6:415–22.CrossRef Ho CY, Abbasi SA, Neilan TG, et al. T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy. Circulat Cardiovasc Imag. 2013;6:415–22.CrossRef
93.
Zurück zum Zitat Malek LA, Werys K, Klopotowski M, et al. Native T1-mapping for non-contrast assessment of myocardial fibrosis in patients with hypertrophic cardiomyopathy—comparison with late enhancement quantification. Magn Reson Imaging. 2015;33:718–24.PubMedCrossRef Malek LA, Werys K, Klopotowski M, et al. Native T1-mapping for non-contrast assessment of myocardial fibrosis in patients with hypertrophic cardiomyopathy—comparison with late enhancement quantification. Magn Reson Imaging. 2015;33:718–24.PubMedCrossRef
94.
Zurück zum Zitat Wang C, Zheng J, Sun J, et al. Endogenous contrast T1rho cardiac magnetic resonance for myocardial fibrosis in hypertrophic cardiomyopathy patients. J Cardiol 2015. Wang C, Zheng J, Sun J, et al. Endogenous contrast T1rho cardiac magnetic resonance for myocardial fibrosis in hypertrophic cardiomyopathy patients. J Cardiol 2015.
95.
Zurück zum Zitat Nacif MS, Kawel N, Lee JJ, et al. Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. Radiology. 2012;264:876–83.PubMedCentralPubMedCrossRef Nacif MS, Kawel N, Lee JJ, et al. Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. Radiology. 2012;264:876–83.PubMedCentralPubMedCrossRef
96.
Zurück zum Zitat Bandula S, White SK, Flett AS, et al. Measurement of myocardial extracellular volume fraction by using equilibrium contrast-enhanced CT: validation against histologic findings. Radiology. 2013;269:396–403.PubMedCrossRef Bandula S, White SK, Flett AS, et al. Measurement of myocardial extracellular volume fraction by using equilibrium contrast-enhanced CT: validation against histologic findings. Radiology. 2013;269:396–403.PubMedCrossRef
97.
Zurück zum Zitat Almaas VM, Haugaa KH, Strom EH, et al. Increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy. Europace : European Pacing, Arrhythmias, Cardiac Electrophysiol: J Work Group Cardiac Pacing, arrhythmias, Cardiac Cell Electrophysiol Europ Soc Cardiol. 2013;15:1319–27.CrossRef Almaas VM, Haugaa KH, Strom EH, et al. Increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy. Europace : European Pacing, Arrhythmias, Cardiac Electrophysiol: J Work Group Cardiac Pacing, arrhythmias, Cardiac Cell Electrophysiol Europ Soc Cardiol. 2013;15:1319–27.CrossRef
98.
Zurück zum Zitat Correia E, Rodrigues B, Santos LF, et al. Longitudinal left ventricular strain in hypertrophic cardiomyopathy: correlation with nonsustained ventricular tachycardia. Echocardiography. 2011;28:709–14.PubMedCrossRef Correia E, Rodrigues B, Santos LF, et al. Longitudinal left ventricular strain in hypertrophic cardiomyopathy: correlation with nonsustained ventricular tachycardia. Echocardiography. 2011;28:709–14.PubMedCrossRef
99.
Zurück zum Zitat Zhang YD, Li M, Qi L, et al. Hypertrophic cardiomyopathy: cardiac structural and microvascular abnormalities as evaluated with multi-parametric MRI. Eur J Radiol 2015. Zhang YD, Li M, Qi L, et al. Hypertrophic cardiomyopathy: cardiac structural and microvascular abnormalities as evaluated with multi-parametric MRI. Eur J Radiol 2015.
100.
Zurück zum Zitat Timmer SA, Knaapen P. Coronary microvascular function, myocardial metabolism, and energetics in hypertrophic cardiomyopathy: insights from positron emission tomography. Europ Heart J Cardiovasc Imag. 2013;14:95–101.CrossRef Timmer SA, Knaapen P. Coronary microvascular function, myocardial metabolism, and energetics in hypertrophic cardiomyopathy: insights from positron emission tomography. Europ Heart J Cardiovasc Imag. 2013;14:95–101.CrossRef
101.
Zurück zum Zitat Olivotto I, Cecchi F, Gistri R, et al. Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2006;47:1043–8.PubMedCrossRef Olivotto I, Cecchi F, Gistri R, et al. Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2006;47:1043–8.PubMedCrossRef
102.
Zurück zum Zitat Cecchi F, Olivotto I, Gistri R, et al. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med. 2003;349:1027–35.PubMedCrossRef Cecchi F, Olivotto I, Gistri R, et al. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med. 2003;349:1027–35.PubMedCrossRef
103.
105.
Zurück zum Zitat Child N, Muhr T, Sammut E, et al. Prevalence of myocardial crypts in a large retrospective cohort study by cardiovascular magnetic resonance. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2014;16:66.CrossRef Child N, Muhr T, Sammut E, et al. Prevalence of myocardial crypts in a large retrospective cohort study by cardiovascular magnetic resonance. J Cardiovasc Magnet Resonance : Off J Soc Cardiovasc Magnet Resonance. 2014;16:66.CrossRef
106.
Zurück zum Zitat Erol C, Koplay M, Olcay A, et al. Congenital left ventricular wall abnormalities in adults detected by gated cardiac multidetector computed tomography: clefts, aneurysms, diverticula and terminology problems. Eur J Radiol 2012. Erol C, Koplay M, Olcay A, et al. Congenital left ventricular wall abnormalities in adults detected by gated cardiac multidetector computed tomography: clefts, aneurysms, diverticula and terminology problems. Eur J Radiol 2012.
107.
Zurück zum Zitat Johansson B, Maceira AM, Babu-Narayan SV, et al. Clefts can be seen in the basal inferior wall of the left ventricle and the interventricular septum in healthy volunteers as well as patients by cardiovascular magnetic resonance. J Am Coll Cardiol. 2007;50:1294–5.PubMedCrossRef Johansson B, Maceira AM, Babu-Narayan SV, et al. Clefts can be seen in the basal inferior wall of the left ventricle and the interventricular septum in healthy volunteers as well as patients by cardiovascular magnetic resonance. J Am Coll Cardiol. 2007;50:1294–5.PubMedCrossRef
108.
Zurück zum Zitat Petryka J, Baksi AJ, Prasad SK, et al. Prevalence of inferobasal myocardial crypts among patients referred for cardiovascular magnetic resonance. Circulat Cardiovasc Imag. 2014;7:259–64.CrossRef Petryka J, Baksi AJ, Prasad SK, et al. Prevalence of inferobasal myocardial crypts among patients referred for cardiovascular magnetic resonance. Circulat Cardiovasc Imag. 2014;7:259–64.CrossRef
109.
Zurück zum Zitat Germans T, Wilde AA, Dijkmans PA, et al. Structural abnormalities of the inferoseptal left ventricular wall detected by cardiac magnetic resonance imaging in carriers of hypertrophic cardiomyopathy mutations. J Am Coll Cardiol. 2006;48:2518–23.PubMedCrossRef Germans T, Wilde AA, Dijkmans PA, et al. Structural abnormalities of the inferoseptal left ventricular wall detected by cardiac magnetic resonance imaging in carriers of hypertrophic cardiomyopathy mutations. J Am Coll Cardiol. 2006;48:2518–23.PubMedCrossRef
110.
Zurück zum Zitat Brouwer WP, Germans T, Head MC, et al. Multiple myocardial crypts on modified long-axis view are a specific finding in pre-hypertrophic HCM mutation carriers. Europ Heart J Cardiovasc Imag. 2012;13:292–7.CrossRef Brouwer WP, Germans T, Head MC, et al. Multiple myocardial crypts on modified long-axis view are a specific finding in pre-hypertrophic HCM mutation carriers. Europ Heart J Cardiovasc Imag. 2012;13:292–7.CrossRef
111.
Zurück zum Zitat Maron MS, Rowin EJ, Lin D, et al. Prevalence and clinical profile of myocardial crypts in hypertrophic cardiomyopathy. Circulat Cardiovasc Imag 2012. Maron MS, Rowin EJ, Lin D, et al. Prevalence and clinical profile of myocardial crypts in hypertrophic cardiomyopathy. Circulat Cardiovasc Imag 2012.
Metadaten
Titel
Imaging in Deciphering Histological Substrates in Hypertrophic Cardiomyopathy
verfasst von
Raquel Sukhbir
Rabah Alreshq
Nicholas Child
Publikationsdatum
01.10.2015
Verlag
Springer US
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 10/2015
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-015-9355-8

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