Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Das Thema chronische Unterbauch- und Viszeralschmerzen wird im Live-Webinar am 7. Mai von 17.30 bis 19 Uhr aus internistischer, gynäkologischer und psychologisch-neurowissenschaftlicher Perspektive beleuchtet. Besprochen werden krankheitsbedingte Ursachen, Mechanismen der kognitiven Schmerzmodulation sowie mögliche Therapieoptionen. Die Fortbildung ist mit 2 CME-Punkten zertifiziert. Melden Sie sich jetzt an!
Erweiterte Suche
Anmelden
nach oben
Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 6/2017

02.11.2017 | Osteoimmunology (MB Humphrey and M Nakamura, Section Editors)

Immune Contributions to Osteoarthritis

verfasst von: Erika Barboza Prado Lopes, Adrian Filiberti, Syed Ali Husain, Mary Beth Humphrey

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose of the Review

Mounting evidence supports a role of low-grade inflammation in the pathophysiology of osteoarthritis (OA). We review and discuss the role of synovitis, complement activation, cytokines, and immune cell population in OA.

Recent Findings

Using newer imaging modalities, synovitis is found in the majority of knees with OA. Complement activation and pro-inflammatory cytokines play a significant role in the development of cartilage destruction and synovitis. Immune cell infiltration of OA synovial tissue by sub-populations of T cells and activated macrophages correlates with OA disease progression and pain.

Summary

The innate and acquired immune system plays a key role in the low-grade inflammation found associated with OA. Targets of these pathways my hold promise for future disease-modifying osteoarthritis drugs (DMOADs).
Literatur
1.
2.
Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL, et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone research. 2017;5:16044.CrossRefPubMedPubMedCentral
3.
Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis. 2012;2:2012.
4.
Huber-Lang M, Kovtun A, Ignatius A. The role of complement in trauma and fracture healing. Semin Immunol. 2013;25(1):73–8.CrossRefPubMed
5.
• Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther. 2017;19(1):18. This is an excellent review of the various imaging modalities used to detect synovitis in OA as well as data on the longitudinal outcomes of OA symptoms as it relates to synovitis. CrossRefPubMedPubMedCentral
6.
Liu-Bryan R, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015;11(1):35–44.CrossRefPubMed
7.
Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis—results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthr Cartil. 2005;13(5):361–7.CrossRefPubMed
8.
Sarmanova A, Hall M, Moses J, Doherty M, Zhang W. Synovial changes detected by ultrasound in people with knee osteoarthritis—a meta-analysis of observational studies. Osteoarthr Cartil. 2016;24(8):1376–83.CrossRefPubMedPubMedCentral
9.
Neogi T, Guermazi A, Roemer F, Nevitt MC, Scholz J, Arendt-Nielsen L, et al. Association of joint inflammation with pain sensitization in knee osteoarthritis: the Multicenter Osteoarthritis Study. Arthritis & rheumatology. 2016;68(3):654–61.CrossRef
10.
Wallace G, Cro S, Dore C, King L, Kluzek S, Price A, et al. Associations between clinical evidence of inflammation and synovitis in symptomatic knee osteoarthritis: a substudy of the VIDEO trial. Arthritis Care Res (Hoboken). 2016;
11.
Jaremko JL, Jeffery D, Buller M, Wichuk S, McDougall D, Lambert RG, et al. Preliminary validation of the Knee Inflammation MRI Scoring System (KIMRISS) for grading bone marrow lesions in osteoarthritis of the knee: data from the Osteoarthritis Initiative. RMD Open. 2017;3(1):e000355.CrossRefPubMedPubMedCentral
12.
Damman W, Liu R, Bloem JL, Rosendaal FR, Reijnierse M, Kloppenburg M. Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2 years in hand osteoarthritis. Ann Rheum Dis. 2017;76(1):214–7.CrossRefPubMed
13.
Liu R, Damman W, Reijnierse M, Bloem JL, Rosendaal FR, Kloppenburg M. Bone marrow lesions on magnetic resonance imaging in hand osteoarthritis are associated with pain and interact with synovitis. Osteoarthr Cartil. 2017;
14.
Mancarella L, Addimanda O, Cavallari C, Meliconi R. Synovial inflammation drives structural damage in hand osteoarthritis: a narrative literature review. Curr Rheumatol Rev. 2017;13(1):43–50.
15.
Felson DT, Niu J, Neogi T, Goggins J, Nevitt MC, Roemer F, et al. Synovitis and the risk of knee osteoarthritis: the MOST Study. Osteoarthr Cartil. 2016;24(3):458–64.CrossRefPubMed
16.
Sharma L, Hochberg M, Nevitt M, Guermazi A, Roemer F, Crema MD, et al. Knee tissue lesions and prediction of incident knee osteoarthritis over 7 years in a cohort of persons at higher risk. Osteoarthr Cartil. 2017;25(7):1068–75.
17.
18.
Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005;64(9):1263–7.CrossRefPubMedPubMedCentral
19.
Hugle T, Geurts J. What drives osteoarthritis?-synovial versus subchondral bone pathology. Rheumatology (Oxford, England). 2017;56(9):1461–71.
20.
Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis)! Osteoarthr Cartil. 2013;21(1):16–21.CrossRefPubMed
21.
Raghu H, Lepus CM, Wang Q, Wong HH, Lingampalli N, Oliviero F, et al. CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis. Ann Rheum Dis. 2017;76(5):914–22.CrossRefPubMed
22.
•• Rahmati M, Mobasheri A, Mozafari M. Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects, and future challenges. Bone. 2016;85:81–90. This is an excellent and comprehensive review of inflammatory mediators, possible biomarkers, and cellular components of synovitis that mediate OA. CrossRefPubMed
23.
Bernardini G, Benigni G, Scrivo R, Valesini G, Santoni A. The multifunctional role of the chemokine system in arthritogenic processes. Curr Rheumatol Rep. 2017;19(3):11.CrossRefPubMed
24.
Haseeb A, Haqqi TM. Immunopathogenesis of osteoarthritis. Clinical immunology (Orlando, Fla). 2013;146(3):185–96.CrossRef
25.
Yang P, Tan J, Yuan Z, Meng G, Bi L, Liu J. Expression profile of cytokines and chemokines in osteoarthritis patients: proinflammatory roles for CXCL8 and CXCL11 to chondrocytes. Int Immunopharmacol. 2016;40:16–23.CrossRefPubMed
26.
Scanzello CR. Chemokines and inflammation in osteoarthritis: Insights from patients and animal models. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2017;35(4):735–9.CrossRef
27.
Li L, Jiang BE. Serum and synovial fluid chemokine ligand 2/monocyte chemoattractant protein 1 concentrations correlates with symptomatic severity in patients with knee osteoarthritis. Ann Clin Biochem. 2015;52(Pt 2):276–82.CrossRefPubMed
28.
Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012;109(50):20602–7.CrossRefPubMedPubMedCentral
29.
Miotla Zarebska J, Chanalaris A, Driscoll C, Burleigh A, Miller RE, Malfait AM, et al. CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy. Osteoarthr Cartil. 2017;25(3):406–12.CrossRefPubMedPubMedCentral
30.
Hulin-Curtis SL, Bidwell JL, Perry MJ. Association between CCL2 haplotypes and knee osteoarthritis. International journal of immunogenetics. 2013;40(4):280–3.CrossRefPubMed
31.
Beekhuizen M, Gierman LM, van Spil WE, Van Osch GJVM, Huizinga TWJ, Saris DBF, et al. An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid. Osteoarthr Cartil. 2013;21(7):918–22.CrossRefPubMed
32.
Takebe K, Rai MF, Schmidt EJ, Sandell LJ. The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone. Osteoarthr Cartil. 2015;23(3):454–61.CrossRefPubMed
33.
Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, et al. A homeostatic function of CXCR2 signalling in articular cartilage. Ann Rheum Dis. 2015;74(12):2207–15.CrossRefPubMed
34.
Karsdal MA, Bay-Jensen AC, Lories RJ, Abramson S, Spector T, Pastoureau P, et al. The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? Ann Rheum Dis. 2014;73(2):336–48.CrossRefPubMed
35.
Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11(9):785–97.CrossRefPubMedPubMedCentral
36.
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT. Complement system part i—molecular mechanisms of activation and regulation. Front Immunol. 2015;6:262.PubMedPubMedCentral
37.
Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT. Complement system part II: role in immunity. Front Immunol. 2015;6:257.PubMedPubMedCentral
38.
Carroll MC. The complement system in regulation of adaptive immunity. Nat Immunol. 2004;5(10):981–6.CrossRefPubMed
39.
Onuma H, Masuko-Hongo K, Yuan G, Sakata M, Nakamura H, Kato T, et al. Expression of the anaphylatoxin receptor C5aR (CD88) by human articular chondrocytes. Rheumatol Int. 2002;22(2):52–5.CrossRefPubMed
40.
Struglics A, Okroj M, Sward P, Frobell R, Saxne T, Lohmander LS, et al. The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis. Arthritis Res Ther. 2016;18(1):223.CrossRefPubMedPubMedCentral
41.
Huber-Lang M, Ignatius A, Brenner RE. Role of complement on broken surfaces after trauma. Adv Exp Med Biol. 2015;865:43–55.CrossRefPubMed
42.
Happonen KE, Heinegard D, Saxne T, Blom AM. Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases. Immunobiology. 2012;217(11):1088–96.CrossRefPubMed
43.
Sturfelt G, Truedsson L. Complement in the immunopathogenesis of rheumatic disease. Nat Rev Rheumatol. 2012;8(8):458–68.CrossRefPubMed
44.
45.
John T, Stahel PF, Morgan SJ, Schulze-Tanzil G. Impact of the complement cascade on posttraumatic cartilage inflammation and degradation. Histol Histopathol. 2007;22(7):781–90.PubMed
46.
Ballanti E, Perricone C, di Muzio G, Kroegler B, Chimenti MS, Graceffa D, et al. Role of the complement system in rheumatoid arthritis and psoriatic arthritis: relationship with anti-TNF inhibitors. Autoimmun Rev. 2011;10(10):617–23.CrossRefPubMed
47.
Cantatore FP, Benazzo F, Ribatti D, Lapadula G, D’Amico S, Tursi A, et al. Early alteration of synovial membrane in osteoarthrosis. Clin Rheumatol. 1988;7(2):214–9.CrossRefPubMed
48.
Corvetta A, Pomponio G, Rinaldi N, Luchetti MM, Di Loreto C, Stramazzotti D. Terminal complement complex in synovial tissue from patients affected by rheumatoid arthritis, osteoarthritis and acute joint trauma. Clin Exp Rheumatol. 1992;10(5):433–8.PubMed
49.
Konttinen YT, Ceponis A, Meri S, Vuorikoski A, Kortekangas P, Sorsa T, et al. Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane. Ann Rheum Dis. 1996;55(12):888–94.CrossRefPubMedPubMedCentral
50.
Gobezie R, Kho A, Krastins B, Sarracino DA, Thornhill TS, Chase M, et al. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther. 2007;9(2):R36.CrossRefPubMedPubMedCentral
51.
Orlowsky EW, Kraus VB. The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive. J Rheumatol. 2015;42(3):363–71.CrossRefPubMedPubMedCentral
52.
Bradley K, North J, Saunders D, Schwaeble W, Jeziorska M, Woolley DE, et al. Synthesis of classical pathway complement components by chondrocytes. Immunology. 1996;88(4):648–56.PubMedPubMedCentral
53.
Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, et al. Identification of a central role for complement in osteoarthritis. Nat Med. 2011;17(12):1674–9.CrossRefPubMedPubMedCentral
54.
Melin Furst C, Morgelin M, Vadstrup K, Heinegard D, Aspberg A, Blom AM. The C-type lectin of the aggrecan G3 domain activates complement. PLoS One. 2013;8(4):e61407.CrossRefPubMedPubMedCentral
55.
Kalchishkova N, Furst CM, Heinegard D, Blom AM. NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H. J Biol Chem. 2011;286(32):27915–26.CrossRefPubMedPubMedCentral
56.
Freria CM, Velloso LA, Oliveira AL. Opposing effects of Toll-like receptors 2 and 4 on synaptic stability in the spinal cord after peripheral nerve injury. J Neuroinflammation. 2012;9:240.CrossRefPubMedPubMedCentral
57.
Lepus CM, Song JJ, Wang Q, Wagner CA, Lindstrom TM, Chu CR, et al. Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis. Arthritis & Rheumatology. 2014;66(1):101–6.CrossRef
58.
• Kraus VB, McDaniel G, Huebner JL, Stabler TV, Pieper CF, Shipes SW, et al. Direct in vivo evidence of activated macrophages in human osteoarthritis. Osteoarthr Cartil. 2016;24(9):1613–21. This paper shows activated macrophages are very common in human OA in vivo. CrossRefPubMedPubMedCentral
59.
60.
Clavijo-Cornejo D, Martinez-Flores K, Silva-Luna K, Martinez-Nava GA, Fernandez-Torres J, Zamudio-Cuevas Y, et al. The overexpression of NALP3 inflammasome in knee osteoarthritis is associated with synovial membrane prolidase and NADPH oxidase 2. Oxidative Med Cell Longev. 2016;2016:1472567.CrossRef
61.
Gibilisco PA, Schumacher HR Jr, Hollander JL, Soper KA. Synovial fluid crystals in osteoarthritis. Arthritis Rheum. 1985;28(5):511–5.CrossRefPubMed
62.
Fuerst M, Bertrand J, Lammers L, Dreier R, Echtermeyer F, Nitschke Y, et al. Calcification of articular cartilage in human osteoarthritis. Arthritis Rheum. 2009;60(9):2694–703.CrossRefPubMed
63.
Fuerst M, Niggemeyer O, Lammers L, Schafer F, Lohmann C, Ruther W. Articular cartilage mineralization in osteoarthritis of the hip. BMC Musculoskelet Disord. 2009;10:166.CrossRefPubMedPubMedCentral
64.
Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci U S A. 2011;108(36):14867–72.CrossRefPubMedPubMedCentral
65.
Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;
66.
Corr EM, Cunningham CC, Helbert L, McCarthy GM, Dunne A. Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells. Arthritis Research & Therapy. 2017;19(1):23.CrossRef
67.
de Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE, et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthr Cartil. 2012;20(12):1484–99.CrossRefPubMed
68.
69.
Pessler F, Chen LX, Dai L, Gomez-Vaquero C, Diaz-Torne C, Paessler ME, et al. A histomorphometric analysis of synovial biopsies from individuals with Gulf War Veterans’ Illness and joint pain compared to normal and osteoarthritis synovium. Clin Rheumatol. 2008;27(9):1127–34.CrossRefPubMed
70.
Saito I, Koshino T, Nakashima K, Uesugi M, Saito T. Increased cellular infiltrate in inflammatory synovia of osteoarthritic knees. Osteoarthr Cartil. 2002;10(2):156–62.CrossRefPubMed
71.
Pawlowska J, Mikosik A, Soroczynska-Cybula M, Jozwik A, Luczkiewicz P, Mazurkiewicz S, et al. Different distribution of CD4 and CD8 T cells in synovial membrane and peripheral blood of rheumatoid arthritis and osteoarthritis patients. Folia Histochem Cytobiol. 2009;47(4):627–32.PubMed
72.
Moradi B, Rosshirt N, Tripel E, Kirsch J, Barie A, Zeifang F, et al. Unicompartmental and bicompartmental knee osteoarthritis show different patterns of mononuclear cell infiltration and cytokine release in the affected joints. Clin Exp Immunol. 2015;180(1):143–54.CrossRefPubMedPubMedCentral
73.
Sakkas LI, Koussidis G, Avgerinos E, Gaughan J, Platsoucas CD. Decreased expression of the CD3zeta chain in T cells infiltrating the synovial membrane of patients with osteoarthritis. Clin Diagn Lab Immunol. 2004;11(1):195–202.PubMedPubMedCentral
74.
Klein-Wieringa IR, de Lange-Brokaar BJ, Yusuf E, Andersen SN, Kwekkeboom JC, Kroon HM, et al. Inflammatory cells in patients with endstage knee osteoarthritis: a comparison between the synovium and the infrapatellar fat pad. J Rheumatol. 2016;43(4):771–8.CrossRefPubMed
75.
Hussein MR, Fathi NA, El-Din AM, Hassan HI, Abdullah F, Al-Hakeem E, et al. Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations. Pathol Oncol Res. 2008;14(3):321–8.CrossRefPubMed
76.
Ponchel F, Burska AN, Hensor EM, Raja R, Campbell M, Emery P, et al. Changes in peripheral blood immune cell composition in osteoarthritis. Osteoarthr Cartil. 2015;23(11):1870–8.CrossRefPubMedPubMedCentral
77.
Qi C, Shan Y, Wang J, Ding F, Zhao D, Yang T, et al. Circulating T helper 9 cells and increased serum interleukin-9 levels in patients with knee osteoarthritis. Clin Exp Pharmacol Physiol. 2016;43(5):528–34.CrossRefPubMed
78.
Moradi B, Schnatzer P, Hagmann S, Rosshirt N, Gotterbarm T, Kretzer JP, et al. CD4(+)CD25(+)/highCD127low/(-) regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints—analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood. Arthritis Research & Therapy. 2014;16(2):R97.CrossRef
79.
Li S, Wan J, Anderson W, Sun H, Zhang H, Peng X, et al. Downregulation of IL-10 secretion by Treg cells in osteoarthritis is associated with a reduction in Tim-3 expression. Biomed Pharmacother. 2016;79:159–65.CrossRefPubMed
80.
Yang S, Wang J, Chen F, Liu G, Weng Z, Chen J. Elevated Galectin-9 Suppresses Th1 Effector Function and Induces Apoptosis of Activated CD4+ T Cells in Osteoarthritis. Inflammation. 2017;
81.
Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi J, Oyamada A, et al. Preferential accumulation of activated Th1 cells not only in rheumatoid arthritis but also in osteoarthritis joints. J Rheumatol. 2011;38(8):1569–75.CrossRefPubMed
82.
Sakkas LI, Scanzello C, Johanson N, Burkholder J, Mitra A, Salgame P, et al. T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis. Clin Diagn Lab Immunol. 1998;5(4):430–7.PubMedPubMedCentral
83.
Ishii H, Tanaka H, Katoh K, Nakamura H, Nagashima M, Yoshino S. Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis. Osteoarthr Cartil. 2002;10(4):277–81.CrossRefPubMed
84.
Zhang L, Li JM, Liu XG, Ma DX, Hu NW, Li YG, et al. Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis. J Clin Immunol. 2011;31(4):606–14.CrossRefPubMed
85.
Zhang L, Li YG, Li YH, Qi L, Liu XG, Yuan CZ, et al. Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis. PLoS One. 2012;7(4):e31000.CrossRefPubMedPubMedCentral
86.
Shan Y, Qi C, Liu Y, Gao H, Zhao D, Jiang Y. Increased frequency of peripheral blood follicular helper T cells and elevated serum IL21 levels in patients with knee osteoarthritis. Mol Med Rep. 2017;15(3):1095–102.CrossRefPubMedPubMedCentral
87.
de Lange-Brokaar BJ, Kloppenburg M, Andersen SN, Dorjee AL, Yusuf E, Herb-van Toorn L, et al. Characterization of synovial mast cells in knee osteoarthritis: association with clinical parameters. Osteoarthr Cartil. 2016;24(4):664–71.CrossRefPubMed
88.
Da RR, Qin Y, Baeten D, Zhang YB. cell clonal expansion and somatic hypermutation of Ig variable heavy chain genes in the synovial membrane of patients with osteoarthritis. J Immunol. 2007;178(1):557–65.CrossRefPubMed
89.
Kummer JA, Tak PP, Brinkman BM, van Tilborg AA, Kamp AM, Verweij CL, et al. Expression of granzymes A and B in synovial tissue from patients with rheumatoid arthritis and osteoarthritis. Clin Immunol Immunopathol. 1994;73(1):88–95.CrossRefPubMed
90.
Fowlkes V, Wilson CG, Carver W, Goldsmith EC. Mechanical loading promotes mast cell degranulation via RGD-integrin dependent pathways. J Biomech. 2013;46(4):788–95.CrossRefPubMed
91.
Okamura Y, Mishima S, Kashiwakura JI, Sasaki-Sakamoto T, Toyoshima S, Kuroda K, et al. The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis. Allergology international : official journal of the Japanese Society of Allergology. 2017;
Metadaten
Titel
Immune Contributions to Osteoarthritis
verfasst von
Erika Barboza Prado Lopes
Adrian Filiberti
Syed Ali Husain
Mary Beth Humphrey
Publikationsdatum
02.11.2017
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 6/2017
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-017-0411-y

Weitere Artikel der Ausgabe 6/2017

Current Osteoporosis Reports 6/2017 Zur Ausgabe

Pediatrics (L Ward and E Imel, Section Editors)

Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment

Craniofacial Skeleton (E Roberts, Section Editor)

Dental Manifestations of Pediatric Bone Disorders

Nutrition, Exercise and Lifestyle in Osteoporosis (S Shapses and J Lappe, Section Editors)

High Dietary Protein Intake and Protein-Related Acid Load on Bone Health

Therapeutics and Medical Management (S Jan de Beur and B Clarke, Section Editors)

The Trabecular Bone Score (TBS) Complements DXA and the FRAX as a Fracture Risk Assessment Tool in Routine Clinical Practice

Nutrition, Exercise, and Lifestyle in Osteoporosis (S Shapses and J Lappe, Section Editors)

Current Status of the Female Athlete Triad: Update and Future Directions

Therapeutics and Medical Management (S Jan de Beur and B Clarke, Section Editors)

Vertebral Imaging in the Diagnosis of Osteoporosis: a Clinician’s Perspective

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärzte und Psychotherapeuten.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders scheint das auf weibliche Kranke zuzutreffen, wie eine Studie zeigt.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise