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European Journal of Medical Research

Erschienen in:

01.12.2011 | Research

Immunohistochemical localization of notch signaling molecules in ameloblastomas

verfasst von: E Muraki, K Nakano, H Maeda, M Takayama, M Jinno, K Kubo, W Yoshida, H Hasegawa, T Kawakami

Erschienen in: European Journal of Medical Research | Ausgabe 6/2011

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Abstract

We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequently positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.

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Titel: Immunohistochemical localization of notch signaling molecules in ameloblastomas
verfasst von: E Muraki
K Nakano
H Maeda
M Takayama
M Jinno
K Kubo
W Yoshida
H Hasegawa
T Kawakami
Publikationsdatum: 01.12.2011
Verlag: BioMed Central
Erschienen in: European Journal of Medical Research / Ausgabe 6/2011
Elektronische ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-16-6-253

Springer Medizin

Abstract

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