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Current Oncology Reports

Erschienen in:

01.10.2017 | Breast Cancer (B Overmoyer, Section Editor)

Immunotherapy in Breast Cancer: the Emerging Role of PD-1 and PD-L1

verfasst von: François Bertucci, Anthony Gonçalves

Erschienen in: Current Oncology Reports | Ausgabe 10/2017

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Abstract

Purpose of Review

The purpose of the review is to summarize the data regarding PD-L1 expression in breast cancer and the results of first clinical trials with PD-1 or PD-L1 inhibitors in patients with metastatic breast cancer.

Recent Findings

PD-L1 expression is heterogeneous across primary breast cancers, and is generally associated with the presence of tumor-infiltrating lymphocytes and the presence of poor-prognosis features such as high grade, and aggressive molecular subtypes (triple-negative (TN), basal, HER2-enriched). Early phase clinical trials using PD-1 or PD-L1 inhibitors alone or in combination have shown objective tumor responses and durable long-term disease control, in heavily pre-treated patients, notably in the TN subtype.

Summary

Blockade of PD-1 or PD-L1 shows impressive antitumor activity in some subsets of breast cancer patients. Many clinical trials are ongoing in the metastatic and neoadjuvant setting, alone and in combination with chemotherapy, targeted therapy, radiotherapy, and/or other immune therapy. The identification of biomarkers predictive for a clinical benefit is warranted.

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Titel: Immunotherapy in Breast Cancer: the Emerging Role of PD-1 and PD-L1
verfasst von: François Bertucci
Anthony Gonçalves
Publikationsdatum: 01.10.2017
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 10/2017
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-017-0627-0

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Springer Medizin

Immunotherapy in Breast Cancer: the Emerging Role of PD-1 and PD-L1

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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