Skip to main content
Erschienen in: Current Oncology Reports 7/2019

01.07.2019 | Geriatric Oncology (AR MacKenzie, Section Editor)

Immunotherapy in Older Adults with Cancer

verfasst von: Richard Curtis Godby, Douglas B. Johnson, Grant R. Williams

Erschienen in: Current Oncology Reports | Ausgabe 7/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

The purpose of this review is to examine the latest research and data on the use of immunotherapy in older adults with cancer in order to identify key gaps in the literature for future research.

Recent Findings

Immune checkpoint inhibitors are gaining approval and being incorporated into routine clinical use for numerous malignancies across age groups due to their overall efficacy and favorable side effect profiles.

Summary

Although immune checkpoint inhibitors appear both safe and effective in older adults, deliberate study of immunotherapies in older adults is highly warranted given the paucity of data in a population with unique immunobiology that comprises the majority of the cancer population worldwide.
Literatur
1.
Zurück zum Zitat Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA. Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(17):2758–65.CrossRef Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA. Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(17):2758–65.CrossRef
2.
Zurück zum Zitat Scher KS, Hurria A. Under-representation of older adults in cancer registration trials: known problem, little progress. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(17):2036–8.CrossRef Scher KS, Hurria A. Under-representation of older adults in cancer registration trials: known problem, little progress. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(17):2036–8.CrossRef
3.
Zurück zum Zitat • Mohile SG, Dale W, Somerfield MR, Schonberg MA, Boyd CM, Burhenn PS, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO Guideline for Geriatric Oncology. J Clin Oncol Off J Am Soc Clin Oncol. 2018:JCO2018788687. Recent ASCO guidelines on the use of geriatric assessment in the management of older adults in oncology. • Mohile SG, Dale W, Somerfield MR, Schonberg MA, Boyd CM, Burhenn PS, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO Guideline for Geriatric Oncology. J Clin Oncol Off J Am Soc Clin Oncol. 2018:JCO2018788687. Recent ASCO guidelines on the use of geriatric assessment in the management of older adults in oncology.
4.
Zurück zum Zitat Jolly TA, Deal AM, Nyrop KA, Williams GR, Pergolotti M, Wood WA, et al. Geriatric assessment-identified deficits in older cancer patients with normal performance status. Oncologist. 2015;20(4):379–85.CrossRef Jolly TA, Deal AM, Nyrop KA, Williams GR, Pergolotti M, Wood WA, et al. Geriatric assessment-identified deficits in older cancer patients with normal performance status. Oncologist. 2015;20(4):379–85.CrossRef
5.
Zurück zum Zitat Kimmick GG, Fleming R, Muss HB, Balducci L. Cancer chemotherapy in older adults. A tolerability perspective. Drugs Aging. 1997;10(1):34–49.CrossRef Kimmick GG, Fleming R, Muss HB, Balducci L. Cancer chemotherapy in older adults. A tolerability perspective. Drugs Aging. 1997;10(1):34–49.CrossRef
6.
Zurück zum Zitat Balducci L, Yates J. General guidelines for the management of older patients with cancer. Oncology (Williston Park). 2000;14(11A):221–7. Balducci L, Yates J. General guidelines for the management of older patients with cancer. Oncology (Williston Park). 2000;14(11A):221–7.
7.
Zurück zum Zitat Williams GR, Rier HN, McDonald A, Shachar SS. Sarcopenia & aging in cancer. Journal of geriatric oncology 2018. Williams GR, Rier HN, McDonald A, Shachar SS. Sarcopenia & aging in cancer. Journal of geriatric oncology 2018.
8.
Zurück zum Zitat Nishijima TF, Deal AM, Williams GR, Sanoff HK, Nyrop KA, Muss HB. Chemotherapy toxicity risk score for treatment decisions in older adults with advanced solid tumors. Oncologist. 2018;23:573–9.CrossRef Nishijima TF, Deal AM, Williams GR, Sanoff HK, Nyrop KA, Muss HB. Chemotherapy toxicity risk score for treatment decisions in older adults with advanced solid tumors. Oncologist. 2018;23:573–9.CrossRef
9.
Zurück zum Zitat Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol Off J Am Soc Clin Oncol. 2011;29(25):3457–65.CrossRef Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol Off J Am Soc Clin Oncol. 2011;29(25):3457–65.CrossRef
10.
Zurück zum Zitat Williams GR. Geriatric assessment: precision medicine for older adults with cancer. Journal of oncology practice / American Society of Clinical Oncology. 2018;14(2):97–8.CrossRef Williams GR. Geriatric assessment: precision medicine for older adults with cancer. Journal of oncology practice / American Society of Clinical Oncology. 2018;14(2):97–8.CrossRef
11.
Zurück zum Zitat Helissey C, Vicier C, Champiat S. The development of immunotherapy in older adults: new treatments, new toxicities? Journal of geriatric oncology. 2016;7(5):325–33.CrossRef Helissey C, Vicier C, Champiat S. The development of immunotherapy in older adults: new treatments, new toxicities? Journal of geriatric oncology. 2016;7(5):325–33.CrossRef
12.
Zurück zum Zitat Murray JM, Kaufmann GR, Hodgkin PD, Lewin SR, Kelleher AD, Davenport MP, et al. Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty. Immunol Cell Biol. 2003;81(6):487–95.CrossRef Murray JM, Kaufmann GR, Hodgkin PD, Lewin SR, Kelleher AD, Davenport MP, et al. Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty. Immunol Cell Biol. 2003;81(6):487–95.CrossRef
13.
Zurück zum Zitat Nikolich-Zugich J. Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J Immunol. 2014;193(6):2622–9.CrossRef Nikolich-Zugich J. Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J Immunol. 2014;193(6):2622–9.CrossRef
14.
Zurück zum Zitat Nikolich-Zugich J. The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol. 2018;19(1):10–9.CrossRef Nikolich-Zugich J. The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol. 2018;19(1):10–9.CrossRef
15.
Zurück zum Zitat Palmer S, Albergante L, Blackburn CC, Newman TJ. Thymic involution and rising disease incidence with age. Proc Natl Acad Sci U S A. 2018;115(8):1883–8.CrossRef Palmer S, Albergante L, Blackburn CC, Newman TJ. Thymic involution and rising disease incidence with age. Proc Natl Acad Sci U S A. 2018;115(8):1883–8.CrossRef
16.
Zurück zum Zitat • Johnson DB, Chandra S, Sosman JA. Immune checkpoint inhibitor toxicity in 2018. JAMA : the journal of the American Medical Association. 2018;320(16):1702–3. JAMA insight review on the clinical presentation and management of the most common and severe immune checkpoint toxicities that oncologists are likely to encounter. CrossRef • Johnson DB, Chandra S, Sosman JA. Immune checkpoint inhibitor toxicity in 2018. JAMA : the journal of the American Medical Association. 2018;320(16):1702–3. JAMA insight review on the clinical presentation and management of the most common and severe immune checkpoint toxicities that oncologists are likely to encounter. CrossRef
17.
Zurück zum Zitat Wang DY, Salem JE, Cohen JV, Chandra S, Menzer C, Ye F, et al. Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis. JAMA Oncol. 2018;4(12):1721–8.CrossRef Wang DY, Salem JE, Cohen JV, Chandra S, Menzer C, Ye F, et al. Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis. JAMA Oncol. 2018;4(12):1721–8.CrossRef
18.
Zurück zum Zitat Postow MA, Sidlow R, Hellmann MD. Immune-related adverse events associated with immune checkpoint blockade. N Engl J Med. 2018;378(2):158–68.CrossRef Postow MA, Sidlow R, Hellmann MD. Immune-related adverse events associated with immune checkpoint blockade. N Engl J Med. 2018;378(2):158–68.CrossRef
19.
Zurück zum Zitat Weber JS, Hodi FS, Wolchok JD, Topalian SL, Schadendorf D, Larkin J, et al. Safety profile of nivolumab monotherapy: a pooled analysis of patients with advanced melanoma. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(7):785–92.CrossRef Weber JS, Hodi FS, Wolchok JD, Topalian SL, Schadendorf D, Larkin J, et al. Safety profile of nivolumab monotherapy: a pooled analysis of patients with advanced melanoma. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(7):785–92.CrossRef
20.
Zurück zum Zitat • Nishijima TF, Shachar SS, Nyrop KA, Muss HB. Safety and tolerability of PD-1/PD-L1 inhibitors compared with chemotherapy in patients with advanced cancer: a meta-analysis. Oncologist. 2017;22(4):470–9. Systematic review and meta-analyses that demonstrate that PD1/PD-L1 inhibitors are overall better tolerated than chemotherapy. CrossRef • Nishijima TF, Shachar SS, Nyrop KA, Muss HB. Safety and tolerability of PD-1/PD-L1 inhibitors compared with chemotherapy in patients with advanced cancer: a meta-analysis. Oncologist. 2017;22(4):470–9. Systematic review and meta-analyses that demonstrate that PD1/PD-L1 inhibitors are overall better tolerated than chemotherapy. CrossRef
21.
Zurück zum Zitat Kanesvaran R, Cordoba R, Maggiore R. Immunotherapy in older adults with advanced cancers: implications for clinical decision-making and future research. American Society of Clinical Oncology educational book / ASCO American Society of Clinical Oncology Meeting. 2018(38):400–14. Kanesvaran R, Cordoba R, Maggiore R. Immunotherapy in older adults with advanced cancers: implications for clinical decision-making and future research. American Society of Clinical Oncology educational book / ASCO American Society of Clinical Oncology Meeting. 2018(38):400–14.
22.
Zurück zum Zitat Elias R, Giobbie-Hurder A, McCleary NJ, Ott P, Hodi FS, Rahma O. Efficacy of PD-1 & PD-L1 inhibitors in older adults: a meta-analysis. J Immunother Cancer. 2018;6(1):26.CrossRef Elias R, Giobbie-Hurder A, McCleary NJ, Ott P, Hodi FS, Rahma O. Efficacy of PD-1 & PD-L1 inhibitors in older adults: a meta-analysis. J Immunother Cancer. 2018;6(1):26.CrossRef
23.
Zurück zum Zitat Elias R, Hartshorn K, Rahma O, Lin N, Snyder-Cappione JE. Aging, immune senescence, and immunotherapy: a comprehensive review. Semin Oncol. 2018;45(4):187–200.CrossRef Elias R, Hartshorn K, Rahma O, Lin N, Snyder-Cappione JE. Aging, immune senescence, and immunotherapy: a comprehensive review. Semin Oncol. 2018;45(4):187–200.CrossRef
24.
Zurück zum Zitat Elias R, Morales J, Rehman Y, Khurshid H. Immune checkpoint inhibitors in older adults. Curr Oncol Rep. 2016;18(8):47.CrossRef Elias R, Morales J, Rehman Y, Khurshid H. Immune checkpoint inhibitors in older adults. Curr Oncol Rep. 2016;18(8):47.CrossRef
25.
Zurück zum Zitat Wolchok JD, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, et al. Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med. 2017;377(14):1345–56.CrossRef Wolchok JD, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, et al. Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med. 2017;377(14):1345–56.CrossRef
26.
Zurück zum Zitat Atkins MB, Plimack ER, Puzanov I, Fishman MN, McDermott DF, Cho DC, et al. Axitinib in combination with pembrolizumab in patients with advanced renal cell cancer: a non-randomised, open-label, dose-finding, and dose-expansion phase 1b trial. Lancet Oncol. 2018;19(3):405–15.CrossRef Atkins MB, Plimack ER, Puzanov I, Fishman MN, McDermott DF, Cho DC, et al. Axitinib in combination with pembrolizumab in patients with advanced renal cell cancer: a non-randomised, open-label, dose-finding, and dose-expansion phase 1b trial. Lancet Oncol. 2018;19(3):405–15.CrossRef
27.
Zurück zum Zitat Choueiri TK, Larkin J, Oya M, Thistlethwaite F, Martignoni M, Nathan P, et al. Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN Renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial. The lancet oncology. 2018;19(4):451–60.CrossRef Choueiri TK, Larkin J, Oya M, Thistlethwaite F, Martignoni M, Nathan P, et al. Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN Renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial. The lancet oncology. 2018;19(4):451–60.CrossRef
28.
Zurück zum Zitat Advani R, Flinn I, Popplewell L, Forero A, Bartlett NL, Ghosh N, et al. CD47 blockade by Hu5F9-G4 and rituximab in non-Hodgkin’s lymphoma. N Engl J Med. 2018;379(18):1711–21.CrossRef Advani R, Flinn I, Popplewell L, Forero A, Bartlett NL, Ghosh N, et al. CD47 blockade by Hu5F9-G4 and rituximab in non-Hodgkin’s lymphoma. N Engl J Med. 2018;379(18):1711–21.CrossRef
29.
Zurück zum Zitat Neelapu SS, Locke FL, Go WYCAR. T-Cell therapy in large B-cell lymphoma. N Engl J Med. 2018;378(11):1065.CrossRef Neelapu SS, Locke FL, Go WYCAR. T-Cell therapy in large B-cell lymphoma. N Engl J Med. 2018;378(11):1065.CrossRef
30.
Zurück zum Zitat Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017;547(7662):217–21.CrossRef Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017;547(7662):217–21.CrossRef
31.
Zurück zum Zitat Sahin U, Derhovanessian E, Miller M, Kloke BP, Simon P, Lower M, et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature. 2017;547(7662):222–6.CrossRef Sahin U, Derhovanessian E, Miller M, Kloke BP, Simon P, Lower M, et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature. 2017;547(7662):222–6.CrossRef
32.
Zurück zum Zitat Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363(5):411–22.CrossRef Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363(5):411–22.CrossRef
33.
Zurück zum Zitat Kantarjian H, Jabbour E, Topp MS. Blinatumomab for acute lymphoblastic leukemia. N Engl J Med. 2017;376(23):e49.CrossRef Kantarjian H, Jabbour E, Topp MS. Blinatumomab for acute lymphoblastic leukemia. N Engl J Med. 2017;376(23):e49.CrossRef
34.
Zurück zum Zitat Guerard EJ, Deal AM, Chang Y, Williams GR, Nyrop KA, Pergolotti M, et al. Frailty index developed from a cancer-specific geriatric assessment and the association with mortality among older adults with cancer. Journal of the National Comprehensive Cancer Network : JNCCN. 2017;15(7):894–902.CrossRef Guerard EJ, Deal AM, Chang Y, Williams GR, Nyrop KA, Pergolotti M, et al. Frailty index developed from a cancer-specific geriatric assessment and the association with mortality among older adults with cancer. Journal of the National Comprehensive Cancer Network : JNCCN. 2017;15(7):894–902.CrossRef
35.
Zurück zum Zitat Williams GR, Mackenzie A, Magnuson A, Olin R, Chapman A, Mohile S, et al. Comorbidity in older adults with cancer. Journal of geriatric oncology. 2016;7(4):249–57.CrossRef Williams GR, Mackenzie A, Magnuson A, Olin R, Chapman A, Mohile S, et al. Comorbidity in older adults with cancer. Journal of geriatric oncology. 2016;7(4):249–57.CrossRef
36.
Zurück zum Zitat Pawelec G. Does patient age influence anti-cancer immunity? Semin Immunopathol. 2019;41(1):125–31.CrossRef Pawelec G. Does patient age influence anti-cancer immunity? Semin Immunopathol. 2019;41(1):125–31.CrossRef
37.
Zurück zum Zitat Muchnik E, Loh KP, Strawderman M, Magnuson A, Mohile SG, Estrah V, Maggiore RJ Immune checkpoint inhibitors in real-world treatment of older adults with non-small cell lung cancer. J Am Geriatr Soc 2019. Muchnik E, Loh KP, Strawderman M, Magnuson A, Mohile SG, Estrah V, Maggiore RJ Immune checkpoint inhibitors in real-world treatment of older adults with non-small cell lung cancer. J Am Geriatr Soc 2019.
38.
Zurück zum Zitat Johnpulle RA, Conry RM, Sosman JA, Puzanov I, Johnson DB. Responses to immune checkpoint inhibitors in nonagenarians. Oncoimmunology. 2016;5(11):e1234572.CrossRef Johnpulle RA, Conry RM, Sosman JA, Puzanov I, Johnson DB. Responses to immune checkpoint inhibitors in nonagenarians. Oncoimmunology. 2016;5(11):e1234572.CrossRef
39.
Zurück zum Zitat Betof AS, Nipp RD, Giobbie-Hurder A, Johnpulle RAN, Rubin K, Rubinstein SM, et al. Impact of age on outcomes with immunotherapy for patients with melanoma. Oncologist. 2017;22(8):963–71.CrossRef Betof AS, Nipp RD, Giobbie-Hurder A, Johnpulle RAN, Rubin K, Rubinstein SM, et al. Impact of age on outcomes with immunotherapy for patients with melanoma. Oncologist. 2017;22(8):963–71.CrossRef
40.
Zurück zum Zitat Ben-Betzalel G, Steinberg-Silman Y, Stoff R, Asher N, Shapira-Frommer R, Schachter J, et al. Immunotherapy comes of age in octagenarian and nonagenarian metastatic melanoma patients. Eur J Cancer. 2019;108:61–8.CrossRef Ben-Betzalel G, Steinberg-Silman Y, Stoff R, Asher N, Shapira-Frommer R, Schachter J, et al. Immunotherapy comes of age in octagenarian and nonagenarian metastatic melanoma patients. Eur J Cancer. 2019;108:61–8.CrossRef
41.
Zurück zum Zitat Kugel CH 3rd, Douglass SM, Webster MR, Kaur A, Liu Q, Yin X, et al. Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-cell populations. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018;24(21):5347–56.CrossRef Kugel CH 3rd, Douglass SM, Webster MR, Kaur A, Liu Q, Yin X, et al. Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-cell populations. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018;24(21):5347–56.CrossRef
42.
Zurück zum Zitat Padron A, Hurez V, Gupta HB, Clark CA, Pandeswara SL, Yuan B, et al. Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model. Exp Gerontol. 2018;105:146–54.CrossRef Padron A, Hurez V, Gupta HB, Clark CA, Pandeswara SL, Yuan B, et al. Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model. Exp Gerontol. 2018;105:146–54.CrossRef
43.
Zurück zum Zitat Li P, Yang X, Feng Y, Wu L, Ma W, Ding G, et al. The impact of immunosenescence on the efficacy of immune checkpoint inhibitors in melanoma patients: a meta-analysis. Onco Targets Ther. 2018;11:7521–7.CrossRef Li P, Yang X, Feng Y, Wu L, Ma W, Ding G, et al. The impact of immunosenescence on the efficacy of immune checkpoint inhibitors in melanoma patients: a meta-analysis. Onco Targets Ther. 2018;11:7521–7.CrossRef
44.
Zurück zum Zitat Marur S, Singh H, Mishra-Kalyani P, Larkins E, Keegan P, Sridhara R, et al. FDA analyses of survival in older adults with metastatic non-small cell lung cancer in controlled trials of PD-1/PD-L1 blocking antibodies. Semin Oncol. 2018;45(4):220–5.CrossRef Marur S, Singh H, Mishra-Kalyani P, Larkins E, Keegan P, Sridhara R, et al. FDA analyses of survival in older adults with metastatic non-small cell lung cancer in controlled trials of PD-1/PD-L1 blocking antibodies. Semin Oncol. 2018;45(4):220–5.CrossRef
45.
Zurück zum Zitat • Nishijima TF, Muss HB, Shachar SS, Moschos SJ. Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: a systematic review and meta-analysis. Cancer Treat Rev. 2016;45:30–7. Systematic review and meta-analysis that demonstrates a similar benefit in overall survival between older and younger patients treated with immune checkpoint inhibitors. CrossRef • Nishijima TF, Muss HB, Shachar SS, Moschos SJ. Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: a systematic review and meta-analysis. Cancer Treat Rev. 2016;45:30–7. Systematic review and meta-analysis that demonstrates a similar benefit in overall survival between older and younger patients treated with immune checkpoint inhibitors. CrossRef
46.
Zurück zum Zitat Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346(14):1061–6.CrossRef Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346(14):1061–6.CrossRef
Metadaten
Titel
Immunotherapy in Older Adults with Cancer
verfasst von
Richard Curtis Godby
Douglas B. Johnson
Grant R. Williams
Publikationsdatum
01.07.2019
Verlag
Springer US
Erschienen in
Current Oncology Reports / Ausgabe 7/2019
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-019-0806-2

Weitere Artikel der Ausgabe 7/2019

Current Oncology Reports 7/2019 Zur Ausgabe

Breast Cancer (B Overmoyer, Section Editor)

Issues with Fertility in Young Women with Breast Cancer

Geriatric Oncology (AR MacKenzie, Section Editor)

Management of Newly Diagnosed Elderly Multiple Myeloma Patients

Neuro-oncology (Y Umemura, Section Editor)

Targeted Therapies for the Treatment of Glioblastoma in Adults

Gastrointestinal Cancers (J Meyer, Section Editor)

Current Status of Immunotherapies for Treating Pancreatic Cancer

Mammakarzinom: Brustdichte beeinflusst rezidivfreies Überleben

26.05.2024 Mammakarzinom Nachrichten

Frauen, die zum Zeitpunkt der Brustkrebsdiagnose eine hohe mammografische Brustdichte aufweisen, haben ein erhöhtes Risiko für ein baldiges Rezidiv, legen neue Daten nahe.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

Das sind die führenden Symptome junger Darmkrebspatienten

Darmkrebserkrankungen in jüngeren Jahren sind ein zunehmendes Problem, das häufig längere Zeit übersehen wird, gerade weil die Patienten noch nicht alt sind. Welche Anzeichen Ärzte stutzig machen sollten, hat eine Metaanalyse herausgearbeitet.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.