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10.02.2023 | Sleep Breathing Physiology and Disorders • Original Article

Impact of antiallergy agents on CPAP therapy and sleep quality with spring pollinosis in Japanese

verfasst von: Akihisa Yoshikawa, Ayako Inoshita, Naoko Sata, Masahiro Nakamura, Yo Suzuki, Erina Ishimizu, Shoko Suda, Ryo Naito, Takatoshi Kasai, Fumihiko Matsumoto

Erschienen in: Sleep and Breathing | Ausgabe 5/2023

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Abstract

Purpose

Allergic rhinitis (AR) is associated with obstructive sleep apnea (OSA) and nasal obstruction causes decreased adherence to continuous positive airway pressure (CPAP). The purpose is to evaluate the effects of antiallergic agents on CPAP adherence and sleep quality.

Methods

A longitudinal study was made of patients who use CPAP for OSA and treated with antiallergy agents for spring pollinosis. We compared the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), nasal symptoms scores (NSS), and data from CPAP before and after treatment. Then, we classified the subjects into two groups based on the baseline PSQI score: one group without a decreased sleep quality (PSQI < 6) and the other group with decreased sleep quality (PSQI ≥ 6).

Results

Of 28 subjects enrolled, 13 had good sleep quality and 15 had poor sleep quality. PSQI showed significant improvements after medication (p = 0.046). ESS showed no significant differences after AR medication (p = 0.565). Significant improvement was observed after the prescription of antiallergy agents in all items of NSS (sneezing, p < 0.05; rhinorrhea, p < 0.01; nasal obstruction, p < 0.01; QOL, p < 0.01). The percentage of days with CPAP use more than 4 h increased significantly after the administration of rhinitis medication (p = 0.022). In the intragroup comparisons of PSQI ≥ 6 group, PSQI decreased significantly (p < 0.05). For the NSS in intragroup comparisons of PSQI ≥ 6 group, all parameters showed significant improvement (sneezing, p = 0.016; rhinorrhea, p = 0.005; nasal obstruction, p < 0.005; QOL, p < 0.005).

Conclusion

The use of antiallergy agents can improve CPAP adherence and sleep quality in patients with OSA on CPAP.

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Titel: Impact of antiallergy agents on CPAP therapy and sleep quality with spring pollinosis in Japanese
verfasst von: Akihisa Yoshikawa
Ayako Inoshita
Naoko Sata
Masahiro Nakamura
Yo Suzuki
Erina Ishimizu
Shoko Suda
Ryo Naito
Takatoshi Kasai
Fumihiko Matsumoto
Publikationsdatum: 10.02.2023
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 5/2023
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-023-02788-2

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