Impact of atherosclerotic plaque composition on coronary microembolization during percutaneous coronary interventions | springermedizin.de

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Basic Research in Cardiology

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01.11.2008 | ORIGINAL CONTRIBUTION

Impact of atherosclerotic plaque composition on coronary microembolization during percutaneous coronary interventions

verfasst von: Dirk Böse, MD, Clemens von Birgelen, MD, PhD, Xiu Ying Zhou, MD, Axel Schmermund, MD, Sebastian Philipp, MD, Stefan Sack, MD, Thomas Konorza, MD, Stefan Möhlenkamp, MD, Kirsten Leineweber, PhD, Petra Kleinbongard, PhD, William Wijns, MD, PhD, Gerd Heusch, MD, PhD, Raimund Erbel, MD

Erschienen in: Basic Research in Cardiology | Ausgabe 6/2008

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Abstract

Background

Cardiac marker release after percutaneous coronary interventions (PCI) reflects myocardial necrosis which is usually the result of periprocedural (micro)embolization of atherothrombotic debris and associated with impaired left ventricular function and adverse outcome.

Methods

In this prospective study, we examined 55 patients treated by direct stenting of single de-novo lesions to assess the relationship between plaque composition, as determined by preinterventional intravascular ultrasound (IVUS) with radiofrequency data (IVUS-RF) analysis (so-called Virtual Histology) versus coronary microembolization, as determined by serial measurement of cardiac markers. IVUS was performed with an electronic system and 20-MHz IVUS catheters. Serum creatine kinase (CK) and cardiac troponin I (CTnI) were determined before PCI and after 6, 12, and 24 hours.

Results

Plaques had a volume of 99 ± 63 mm³ and were composed of fibrous (61 ± 9%) and fibro-fatty tissue (27 ± 12%), dense calcium (4 ± 3%), and necrotic core (NC) (8 ± 6%). NC volume per se, volume per 10 mm of segment length, and volume % were correlated (r = 0.64, 0.66, and 0.52 respectively; all P < 0.01) with the maximum increase in cardiac markers (CK 55.4 ± 55.7 U/l; CTnI 0.49 ± 0.68 ng/ml). Patients in the 4th quartile of NC volume (>10.8 mm³) had a particularly high increase in markers (P < 0.001). In contrast, total plaque volume and plaque components other than NC had no relation with cardiac markers (ns).

Conclusions

Patients with large NC in culprit lesions may experience more myocardial injury from peri-interventional microembolization. IVUS-RF assessment before PCI has the potential to identify lesions at particular high risk which may help to tailor PCI.

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Titel: Impact of atherosclerotic plaque composition on coronary microembolization during percutaneous coronary interventions
verfasst von: Dirk Böse, MD
Clemens von Birgelen, MD, PhD
Xiu Ying Zhou, MD
Axel Schmermund, MD
Sebastian Philipp, MD
Stefan Sack, MD
Thomas Konorza, MD
Stefan Möhlenkamp, MD
Kirsten Leineweber, PhD
Petra Kleinbongard, PhD
William Wijns, MD, PhD
Gerd Heusch, MD, PhD
Raimund Erbel, MD
Publikationsdatum: 01.11.2008
Verlag: D. Steinkopff-Verlag
Erschienen in: Basic Research in Cardiology / Ausgabe 6/2008
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-008-0745-9

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