Erschienen in:
26.07.2017 | Observational Research
Impact of interstitial lung disease on mortality of patients with rheumatoid arthritis
verfasst von:
Dam Kim, Soo-Kyung Cho, Chan-Bum Choi, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Tae-Hwan Kim, Tae-Jong Kim, Hye-Soon Lee, Joo-Hyun Lee, Jisoo Lee, Shin-Seok Lee, Dae-Hyun Yoo, Bo Young Yoon, Jin Woo Song, Sang-Cheol Bae, Yoon-Kyoung Sung
Erschienen in:
Rheumatology International
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Ausgabe 10/2017
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Abstract
To identify the prevalence of interstitial lung disease (ILD) in Korean patients with rheumatoid arthritis (RA) and assess its effect on mortality. A total of 3555 patients with RA, with chest X-ray or chest computed tomography (CT) data at enrollment were extracted from the KORean Observational study Network for Arthritis cohort, a nationwide prospective cohort for patients with RA in Korea. The patients were classified into two groups: (1) an ILD group by chest X-ray or chest CT scan, and (2) a non-ILD group by these modalities. After comparing the characteristics of the groups at enrollment, mortalities were compared using the log-rank test. To explore the impact of ILD on mortality, Cox proportional hazard models were used. Sixty-four patients (1.8%) were identified with ILD. Male and older patients were more common in the ILD group. During a mean follow-up of 24 months, 6 patients (9.4%) in the ILD group and 25 patients (0.7%) in the non-ILD group died; the survival rate was significantly worse in the ILD group (p < 0.01). On adjusted analysis, ILD was significantly associated with increased mortality (HR 7.89, CI 3.16–19.69, p < 0.01); the risk of death in patients with ILD was even higher than in patients with cardiovascular disease (CVD, HR 4.10, CI 1.79–9.37, p < 0.01). The prevalence of ILD was 1.8% in Korean patients with RA. ILD is a major risk factor for mortality in patients with RA.