Introduction
Cognitive deficits in depression
Cognitive deficits in anxiety disorders
Objective of the analysis
Impact of pharmacological treatment of depressive and anxiety disorders on cognition
References | Diagnose | No. of the patients | Studied compound | Duration of the study | Cognitive battery |
---|---|---|---|---|---|
Borkowska et al. (2007) | Major depressive disorder | 71 | Mirtazapine | 6 months | Wisconsin Card Sorting Test, N-back test, TMT, Stroop Tests |
Braszko et al. (2003) | Depressive symptoms in non-depressive patients | 39 | Captopril, enalapril | 4 weeks | The Rey Auditory Verbal Learning Test, Wechsler Memory Scale |
Chang et al. (2012) | Major depressive disorder | 149 | Fluoxetine, venlafaxine | 6 weeks | Continuous Performance Test (CPT), Finger-Tapping Test (FTT), and Wisconsin Card-Sorting Test (WCST) |
Constant et al. (2005) | Major depressive disorder | 20 | Sertraline | 7 weeks | Phasic Alertness Task, Stroop Test, The Supraliminal and Subliminal Emotional Stroop, |
Galassi et al. 2006
| Major depressive disorder | 48 | Fluoxetine, reboxetine | 6 months | Attentional matrices, Wechsler memory scale, Familial faces recognition, Famous faces recognition, Stem completion test, Autobiographical memory, MLT ‘88: test for historical events, MMSE |
Gorenstein et al. (2006) | Major depression | 42 | Imipramine, clomipramine, fluoxetine, sertraline | >6 months (imipramine for 2.4 ± 0.6 years, clomipramine for 2.8 ± 1.2 years, fluoxetine for 1.8 ± 0.3 years, sertraline for 1.5 ± 0.3 years) | Subjective Memory Questionnaire (SMQ), Verbal recall, Word appreciation task, Digit span forward and backward, Word stem completion, Visual recall (from Memory I, PSS), Digit–Symbol Substitution Test (DSST), Cancellation Task (CT), Symbol Copying Test (SCT), Tapping (from Vienna Test System), Inserting pins (from Vienna Test System), Reaction times (from Foundations I, PSS) |
Gualtieri et al. (2006) | Major depressive disorder | 31 | Citalopram, fluoxetine, escitalopram, paroxetine, mirtazepine, trazodone, venlafaxine, bupropion, sertraline | 4 weeks | Finger Tapping Test, Symbol-digit Cod, Stroop Test, The Shifting Attention Test, Continuous Performance Test |
Han et al. (2011) | Major depression | 281 | Fluoxetine, sertraline, fluvoxamine, paroxetine and citalopram, amitriptyline, desipramine, doxepine, imipramine, nortriptyline, trimipramine clomipramine, maprotiline, tranylcypromine, trazodone, nefazodone, venlafaxine, bupropion | 12 months | Mini-Mental State Examination |
Herrera-Guzmán et al. (2009) | Major depressive disorder | 73 | Escitalopram, duloxetine | 24 weeks | WAIS III vocabulary subtest, WAIS III digit span, Rey auditory verbal learning test (RAVLT), Pattern recognition memory (PRM), Spatial recognition memory (SRM), reaction time (RTI) |
Herrera-Guzmán et al. (2010) | Major depressive disorder | 73 | Escitalopram, duloxetine | 24 weeks | WAIS III vocabulary subtest, WAIS III Digit span, Spatial Working Memory (SWM), Rapid Visual Information Processing (RVIP), Match to Sample Visual Search (MTS), Stroop Test, Intra–Extra-Dimensional Set Shift (ID/ED), Stockings of Cambridge (SOC) |
Klasik et al. (2011) | Major depressive disorder | 20 | Tianeptine | 3 months | Vienna Test System |
Levkovitz et al. (2012) | Major depressive disorder | 46 | SAMe (adjunctive to SRI drug) | 6 weeks | Cognitive and physical symptoms questionnaire (CPFQ) |
Pedrelli et al. (2010) | Major depression disorder | 117 | Tricyclic antidepressants, benzodiazepines, mirtazapine | >10 months | CPFQ |
Pelton et al. (2008) | Depression (major depressive disorder, dysthymic disorder, or depression not otherwise specified | 23 | Donepezil | 12 weeks | Buschke Selective Reminding Test (targeting memory), WAIS-III digit symbol, Trails B (executive function), CFL (verbal fluency), Trails A (attention/psychomotor speed) |
Raskin et al. (2007) | Major depressive disorder | 311 | Duloxetine | 8 weeks | Verbal Learning and Recall Test, the Symbol Digit Substitution Test, the Two-Digit Cancellation Test, the Letter-Number Sequencing Test |
Schrijvers et al. (2009) | Major depressive disorder | 19 | Sertraline | 6 weeks | Computed copying tasks, Symbol Digit Substitution, Task (SDST, a subtest of the Wechsler Adult Intelligence Scale) |
Impact of psychological treatment methods of cognitive impairment in depression and anxiety disorders
Role of cognitive training methods
Neuroimaging studies evidence of the psychotherapy effectiveness in cognitive improvement
Depressive disorders
Anxiety disorders
Importance of methodological limitations
Neuropsychological studies evidence of the beneficial effect of psychotherapy on cognition
Diagnose | No. of patients | Duration of the study | Cognitive battery | Model of psychotherapy | Additional pharmacotherapy | |
---|---|---|---|---|---|---|
Klasik et al. (2012) | Recurrent Depressive Disorder | 60 | 8 weeks | Vienna Test System (VTS) | Psychodynamic | Sertraline (in 2 of 3 examined groups) |
Bastos et al. (2013) | Moderate depression | 272 | 2 years | WAIS-III | Psychodynamic | Fluoxetine (in 2 of 3 examined groups) |
Reinecke et al. (2013) | Panic disorder | 28 | 4 weeks | Attention visual probe task | CBT | Exclusion criterion: psychopharmacological treatment during the last 6 months |
Dobkin et al. (2014) | Major Depressive Disorder (MDD), Dysthymia, or Depression Not Otherwise Specified, Parkinson`s disease | 80 | 10 weeks | Hopkins Verbal Learning Test–Revised (HVLT–R), Delis-Kaplan Executive Function System (D–KEFS), Wechsler Memory Scales, Stroop Color and Word Test | CBT | Stable medication regimen for ≥6 weeks |
Mackin et al. 2013
| Late life depression | 221 | 24 weeks | Stroop Color and Word Test, Hopkins Verbal Learning Test - Revised (HVLT–R), DRS-IP, Wisconsin Card Sorting Test-64 Computer Version, Trail Making Test (TMT) | Problem Solving Therapy, Supportive Therapy | Antidepressant-free participants |