Skip to main content
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 6/2021

07.01.2021 | Brief Report

Impact of surgical timing on survival in patients with infective endocarditis: a time-dependent analysis

verfasst von: Marco Ripa, Stefania Chiappetta, Barbara Castiglioni, Eustachio Agricola, Elena Busnardo, Silvia Carletti, Alessandro Castiglioni, Michele De Bonis, Giovanni La Canna, Chiara Oltolini, Ursola Pajoro, Renée Pasciuta, Chiara Tassan Din, Paolo Scarpellini, on behalf of Ospedale San Raffaele Endocarditis Team

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 6/2021

Einloggen, um Zugang zu erhalten

Abstract

The purpose of this study was to evaluate the impact of surgical timing on survival in patients with left-sided infective endocarditis (IE). This was a retrospective study including 313 patients with left-sided IE between 2009 and 2017. Surgery was defined as urgent (US) or early (ES) if performed within 7 or 28 days, respectively. A multivariable Cox regression analysis including US and ES as time-dependent variables was performed to assess the impact on 1-year mortality. ES was associated with a better survival (aHR 0.349, 95% CI 0.135–0.902), as US (aHR 0.262, 95% CI 0.075–0.915). ES and US were associated with a better prognosis in patients with left-sided IE.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J-P, Del Zotti F et al (2015) 2015 ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 36:3075–3128CrossRef Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J-P, Del Zotti F et al (2015) 2015 ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 36:3075–3128CrossRef
2.
Zurück zum Zitat Habib G, Erba PA, Iung B, Donal E, Cosyns B, Laroche C et al (2019) Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. Eur Heart J 40:3222–3232CrossRef Habib G, Erba PA, Iung B, Donal E, Cosyns B, Laroche C et al (2019) Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. Eur Heart J 40:3222–3232CrossRef
3.
Zurück zum Zitat Chu VH, Park LP, Athan E, Delahaye F, Freiberger T, Lamas C et al (2015) Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis. Circulation. 131:131–140CrossRef Chu VH, Park LP, Athan E, Delahaye F, Freiberger T, Lamas C et al (2015) Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis. Circulation. 131:131–140CrossRef
4.
Zurück zum Zitat Iung B, Doco-Lecompte T, Chocron S, Strady C, Delahaye F, Le Moing V et al (2016) Cardiac surgery during the acute phase of infective endocarditis: discrepancies between European Society of Cardiology guidelines and practices. Eur Heart J 37:840–848CrossRef Iung B, Doco-Lecompte T, Chocron S, Strady C, Delahaye F, Le Moing V et al (2016) Cardiac surgery during the acute phase of infective endocarditis: discrepancies between European Society of Cardiology guidelines and practices. Eur Heart J 37:840–848CrossRef
5.
Zurück zum Zitat Leone S, Ravasio V, Durante-Mangoni E, Crapis M, Carosi G, Scotton PG et al (2012) Epidemiology, characteristics, and outcome of infective endocarditis in Italy: the Italian study on endocarditis. Infection. 40:527–535CrossRef Leone S, Ravasio V, Durante-Mangoni E, Crapis M, Carosi G, Scotton PG et al (2012) Epidemiology, characteristics, and outcome of infective endocarditis in Italy: the Italian study on endocarditis. Infection. 40:527–535CrossRef
6.
Zurück zum Zitat Bishara J, Leibovici L, Gartman-Israel D, Sagie A, Kazakov A, Miroshnik E et al (2001) Long-term outcome of infective endocarditis: the impact of early surgical intervention. Clin Infect Dis 33:1636–1643CrossRef Bishara J, Leibovici L, Gartman-Israel D, Sagie A, Kazakov A, Miroshnik E et al (2001) Long-term outcome of infective endocarditis: the impact of early surgical intervention. Clin Infect Dis 33:1636–1643CrossRef
7.
Zurück zum Zitat Vikram HR, Buenconsejo J, Hasbun R, Quagliarello VJ (2003) Impact of valve surgery on 6-month mortality in adults with complicated, left-sided native valve endocarditis: a propensity analysis. JAMA. 290:3207–3214CrossRef Vikram HR, Buenconsejo J, Hasbun R, Quagliarello VJ (2003) Impact of valve surgery on 6-month mortality in adults with complicated, left-sided native valve endocarditis: a propensity analysis. JAMA. 290:3207–3214CrossRef
8.
Zurück zum Zitat Akowuah EF, Davies W, Oliver S, Stephens J, Riaz I, Zadik P et al (2003) Prosthetic valve endocarditis: early and late outcome following medical or surgical treatment. Heart. 89:269–272CrossRef Akowuah EF, Davies W, Oliver S, Stephens J, Riaz I, Zadik P et al (2003) Prosthetic valve endocarditis: early and late outcome following medical or surgical treatment. Heart. 89:269–272CrossRef
9.
Zurück zum Zitat Mourvillier B, Trouillet J-L, Timsit J-F, Baudot J, Chastre J, Régnier B et al (2004) Infective endocarditis in the intensive care unit: clinical spectrum and prognostic factors in 228 consecutive patients. Intensive Care Med 30:2046–2052CrossRef Mourvillier B, Trouillet J-L, Timsit J-F, Baudot J, Chastre J, Régnier B et al (2004) Infective endocarditis in the intensive care unit: clinical spectrum and prognostic factors in 228 consecutive patients. Intensive Care Med 30:2046–2052CrossRef
10.
Zurück zum Zitat Cabell CH, Abrutyn E, Fowler VG Jr, Hoen B, Miro JM, Corey GR et al (2005) Use of surgery in patients with native valve infective endocarditis: results from the International Collaboration on Endocarditis merged database. Am Heart J 150:1092–1098CrossRef Cabell CH, Abrutyn E, Fowler VG Jr, Hoen B, Miro JM, Corey GR et al (2005) Use of surgery in patients with native valve infective endocarditis: results from the International Collaboration on Endocarditis merged database. Am Heart J 150:1092–1098CrossRef
11.
Zurück zum Zitat Wang A, Pappas P, Anstrom KJ, Abrutyn E, Fowler VG Jr, Hoen B et al (2005) The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort. Am Heart J 150:1086–1091CrossRef Wang A, Pappas P, Anstrom KJ, Abrutyn E, Fowler VG Jr, Hoen B et al (2005) The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort. Am Heart J 150:1086–1091CrossRef
12.
Zurück zum Zitat Sohail MR, Martin KR, Wilson WR, Baddour LM, Harmsen WS, Steckelberg JM (2006) Medical versus surgical management of Staphylococcus aureus prosthetic valve endocarditis. Am J Med 119:147–154CrossRef Sohail MR, Martin KR, Wilson WR, Baddour LM, Harmsen WS, Steckelberg JM (2006) Medical versus surgical management of Staphylococcus aureus prosthetic valve endocarditis. Am J Med 119:147–154CrossRef
13.
Zurück zum Zitat Tleyjeh IM, Ghomrawi HMK, Steckelberg JM, Hoskin TL, Mirzoyev Z, Anavekar NS et al (2007) The impact of valve surgery on 6-month mortality in left-sided infective endocarditis. Circulation. 115:1721–1728CrossRef Tleyjeh IM, Ghomrawi HMK, Steckelberg JM, Hoskin TL, Mirzoyev Z, Anavekar NS et al (2007) The impact of valve surgery on 6-month mortality in left-sided infective endocarditis. Circulation. 115:1721–1728CrossRef
14.
Zurück zum Zitat Aksoy O, Sexton DJ, Wang A, Pappas PA, Kourany W, Chu V et al (2007) Early surgery in patients with infective endocarditis: a propensity score analysis. Clin Infect Dis 44:364–372CrossRef Aksoy O, Sexton DJ, Wang A, Pappas PA, Kourany W, Chu V et al (2007) Early surgery in patients with infective endocarditis: a propensity score analysis. Clin Infect Dis 44:364–372CrossRef
15.
Zurück zum Zitat Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG Jr, Bayer AS et al (2009) Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-prospective cohort study. Arch Intern Med 169:463–473CrossRef Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG Jr, Bayer AS et al (2009) Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-prospective cohort study. Arch Intern Med 169:463–473CrossRef
16.
Zurück zum Zitat Sy RW, Bannon PG, Bayfield MS, Brown C, Kritharides L (2009) Survivor treatment selection bias and outcomes research: a case study of surgery in infective endocarditis. Circ Cardiovasc Qual Outcomes 2:469–474CrossRef Sy RW, Bannon PG, Bayfield MS, Brown C, Kritharides L (2009) Survivor treatment selection bias and outcomes research: a case study of surgery in infective endocarditis. Circ Cardiovasc Qual Outcomes 2:469–474CrossRef
17.
Zurück zum Zitat Nadji G, Rusinaru D, Rémadi J-P, Jeu A, Sorel C, Tribouilloy C (2009) Heart failure in left-sided native valve infective endocarditis: characteristics, prognosis, and results of surgical treatment. Eur J Heart Fail 11:668–675CrossRef Nadji G, Rusinaru D, Rémadi J-P, Jeu A, Sorel C, Tribouilloy C (2009) Heart failure in left-sided native valve infective endocarditis: characteristics, prognosis, and results of surgical treatment. Eur J Heart Fail 11:668–675CrossRef
18.
Zurück zum Zitat Kim D-H, Kang D-H, Lee M-Z, Yun S-C, Kim Y-J, Song J-M et al (2010) Impact of early surgery on embolic events in patients with infective endocarditis. Circulation. 122:S17–S22CrossRef Kim D-H, Kang D-H, Lee M-Z, Yun S-C, Kim Y-J, Song J-M et al (2010) Impact of early surgery on embolic events in patients with infective endocarditis. Circulation. 122:S17–S22CrossRef
19.
Zurück zum Zitat Lalani T, Cabell CH, Benjamin DK, Lasca O, Naber C, Fowler VG Jr et al (2010) Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias. Circulation. 121:1005–1013CrossRef Lalani T, Cabell CH, Benjamin DK, Lasca O, Naber C, Fowler VG Jr et al (2010) Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias. Circulation. 121:1005–1013CrossRef
20.
Zurück zum Zitat Kiefer T, Park L, Tribouilloy C, Cortes C, Casillo R, Chu V et al (2011) Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure. JAMA. 306:2239–2247CrossRef Kiefer T, Park L, Tribouilloy C, Cortes C, Casillo R, Chu V et al (2011) Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure. JAMA. 306:2239–2247CrossRef
21.
Zurück zum Zitat Bannay A, Hoen B, Duval X, Obadia J-F, Selton-Suty C, Le Moing V et al (2011) The impact of valve surgery on short- and long-term mortality in left-sided infective endocarditis: do differences in methodological approaches explain previous conflicting results? Eur Heart J 32:2003–2015CrossRef Bannay A, Hoen B, Duval X, Obadia J-F, Selton-Suty C, Le Moing V et al (2011) The impact of valve surgery on short- and long-term mortality in left-sided infective endocarditis: do differences in methodological approaches explain previous conflicting results? Eur Heart J 32:2003–2015CrossRef
22.
Zurück zum Zitat Funakoshi S, Kaji S, Yamamuro A, Tani T, Kinoshita M, Okada Y et al (2011) Impact of early surgery in the active phase on long-term outcomes in left-sided native valve infective endocarditis. J Thorac Cardiovasc Surg 142:836–42.e1CrossRef Funakoshi S, Kaji S, Yamamuro A, Tani T, Kinoshita M, Okada Y et al (2011) Impact of early surgery in the active phase on long-term outcomes in left-sided native valve infective endocarditis. J Thorac Cardiovasc Surg 142:836–42.e1CrossRef
23.
Zurück zum Zitat Thuny F, Beurtheret S, Mancini J, Gariboldi V, Casalta J-P, Riberi A et al (2011) The timing of surgery influences mortality and morbidity in adults with severe complicated infective endocarditis: a propensity analysis. Eur Heart J 32:2027–2033CrossRef Thuny F, Beurtheret S, Mancini J, Gariboldi V, Casalta J-P, Riberi A et al (2011) The timing of surgery influences mortality and morbidity in adults with severe complicated infective endocarditis: a propensity analysis. Eur Heart J 32:2027–2033CrossRef
24.
Zurück zum Zitat Ohara T, Nakatani S, Kokubo Y, Yamamoto H, Mitsutake K, Hanai S et al (2013) Clinical predictors of in-hospital death and early surgery for infective endocarditis: results of CArdiac Disease REgistration (CADRE), a nation-wide survey in Japan. Int J Cardiol 167:2688–2694CrossRef Ohara T, Nakatani S, Kokubo Y, Yamamoto H, Mitsutake K, Hanai S et al (2013) Clinical predictors of in-hospital death and early surgery for infective endocarditis: results of CArdiac Disease REgistration (CADRE), a nation-wide survey in Japan. Int J Cardiol 167:2688–2694CrossRef
25.
Zurück zum Zitat Lalani T, Chu VH, Park LP, Cecchi E, Corey GR, Durante-Mangoni E et al (2013) In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis. JAMA Intern Med 173:1495–1504CrossRef Lalani T, Chu VH, Park LP, Cecchi E, Corey GR, Durante-Mangoni E et al (2013) In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis. JAMA Intern Med 173:1495–1504CrossRef
26.
Zurück zum Zitat Gálvez-Acebal J, Almendro-Delia M, Ruiz J, de Alarcón A, Martínez-Marcos FJ, Reguera JM et al (2014) Influence of early surgical treatment on the prognosis of left-sided infective endocarditis: a multicenter cohort study. Mayo Clin Proc 89:1397–1405CrossRef Gálvez-Acebal J, Almendro-Delia M, Ruiz J, de Alarcón A, Martínez-Marcos FJ, Reguera JM et al (2014) Influence of early surgical treatment on the prognosis of left-sided infective endocarditis: a multicenter cohort study. Mayo Clin Proc 89:1397–1405CrossRef
27.
Zurück zum Zitat Chirouze C, Alla F, Fowler VG Jr, Sexton DJ, Corey GR, Chu VH et al (2015) Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-prospective cohort study. Clin Infect Dis 60:741–749CrossRef Chirouze C, Alla F, Fowler VG Jr, Sexton DJ, Corey GR, Chu VH et al (2015) Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-prospective cohort study. Clin Infect Dis 60:741–749CrossRef
28.
Zurück zum Zitat Cecchi E, Ciccone G, Chirillo F, Imazio M, Cecconi M, Del Ponte S et al (2018) Mortality and timing of surgery in the left-sided infective endocarditis: an Italian multicentre study. Interact Cardiovasc Thorac Surg 26:602–609CrossRef Cecchi E, Ciccone G, Chirillo F, Imazio M, Cecconi M, Del Ponte S et al (2018) Mortality and timing of surgery in the left-sided infective endocarditis: an Italian multicentre study. Interact Cardiovasc Thorac Surg 26:602–609CrossRef
30.
Zurück zum Zitat Rieg S, von Cube M, Kaasch A, Bonaventura B, Bothe W, Wolkewitz M et al (2018) Investigating the impact of early valve surgery on survival in Staphylococcus aureus infective endocarditis using a marginal structural model approach - results of a large prospectively evaluated cohort. Clin Infect Dis [Internet]. https://doi.org/10.1093/cid/ciy908 Rieg S, von Cube M, Kaasch A, Bonaventura B, Bothe W, Wolkewitz M et al (2018) Investigating the impact of early valve surgery on survival in Staphylococcus aureus infective endocarditis using a marginal structural model approach - results of a large prospectively evaluated cohort. Clin Infect Dis [Internet]. https://​doi.​org/​10.​1093/​cid/​ciy908
31.
Zurück zum Zitat Wang A, Chu VH, Athan E, Delahaye F, Freiberger T, Lamas C et al (2019) Association between the timing of surgery for complicated, left-sided infective endocarditis and survival. Am Heart J 210:108–116CrossRef Wang A, Chu VH, Athan E, Delahaye F, Freiberger T, Lamas C et al (2019) Association between the timing of surgery for complicated, left-sided infective endocarditis and survival. Am Heart J 210:108–116CrossRef
Metadaten
Titel
Impact of surgical timing on survival in patients with infective endocarditis: a time-dependent analysis
verfasst von
Marco Ripa
Stefania Chiappetta
Barbara Castiglioni
Eustachio Agricola
Elena Busnardo
Silvia Carletti
Alessandro Castiglioni
Michele De Bonis
Giovanni La Canna
Chiara Oltolini
Ursola Pajoro
Renée Pasciuta
Chiara Tassan Din
Paolo Scarpellini
on behalf of Ospedale San Raffaele Endocarditis Team
Publikationsdatum
07.01.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 6/2021
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-020-04133-x

Weitere Artikel der Ausgabe 6/2021

European Journal of Clinical Microbiology & Infectious Diseases 6/2021 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.