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Current Hematologic Malignancy Reports
Erschienen in: Current Hematologic Malignancy Reports 6/2016

08.08.2016 | Myelodysplastic Syndromes (D Steensma, Section Editor)

Improving Prognostic Modeling in Myelodysplastic Syndromes

verfasst von: Aziz Nazha, Mikkael A. Sekeres

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 6/2016

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Abstract

Myelodysplastic syndromes (MDSs) are a heterogeneous group of disorders characterized by the accumulation of complex genetic alterations that drive disease pathogenesis and outcome. Several prognostic models have been developed over the last two decades to risk stratify patients with MDS. These models mainly used clinical variables including blast percentage, cytopenias, cytogenetics, transfusion dependency, and age. Recently, somatic mutations in specific genes have been shown to impact overall survival in MDS and can be incorporated into established prognostic models to improve their predictive abilities. Here, we review the advantages and disadvantages of established prognostic models in MDS and the impact of emerging data regarding the incorporation of somatic mutations in risk stratification.
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Metadaten
Titel
Improving Prognostic Modeling in Myelodysplastic Syndromes
verfasst von
Aziz Nazha
Mikkael A. Sekeres
Publikationsdatum
08.08.2016
Verlag
Springer US
Erschienen in
Current Hematologic Malignancy Reports / Ausgabe 6/2016
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-016-0342-1

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