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Odontology
Erschienen in: Odontology 2/2016

31.12.2014 | Original Article

In vitro cytotoxicity of metallic ions released from dental alloys

verfasst von: Ana Milheiro, Kosuke Nozaki, Cornelis J. Kleverlaan, Joris Muris, Hiroyuki Miura, Albert J. Feilzer

Erschienen in: Odontology | Ausgabe 2/2016

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Abstract

The cytotoxicity of a dental alloy depends on, but is not limited to, the extent of its corrosion behavior. Individual ions may have effects on cell viability that are different from metals interacting within the alloy structure. We aimed to investigate the cytotoxicity of individual metal ions in concentrations similar to those reported to be released from Pd-based dental alloys on mouse fibroblast cells. Metal salts were used to prepare seven solutions (concentration range 100 ppm–1 ppb) of the transition metals, such as Ni(II), Pd(II), Cu(II), and Ag(I), and the metals, such as Ga(III), In(III), and Sn(II). Cytotoxicity on mouse fibroblasts L929 was evaluated using the MTT assay. Ni, Cu, and Ag are cytotoxic at 10 ppm, Pd and Ga at 100 ppm. Sn and In were not able to induce cytotoxicity at the tested concentrations. Transition metals were able to induce cytotoxic effects in concentrations similar to those reported to be released from Pd-based dental alloys. Ni, Cu, and Ag were the most cytotoxic followed by Pd and Ga; Sn and In were not cytotoxic. Cytotoxic reactions might be considered in the etiopathogenesis of clinically observed local adverse reactions.
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Metadaten
Titel
In vitro cytotoxicity of metallic ions released from dental alloys
verfasst von
Ana Milheiro
Kosuke Nozaki
Cornelis J. Kleverlaan
Joris Muris
Hiroyuki Miura
Albert J. Feilzer
Publikationsdatum
31.12.2014
Verlag
Springer Japan
Erschienen in
Odontology / Ausgabe 2/2016
Print ISSN: 1618-1247
Elektronische ISSN: 1618-1255
DOI
https://doi.org/10.1007/s10266-014-0192-z

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