Erschienen in:
31.07.2017 | Original Article
In Vitro Mechanical Property Evaluation of Chitosan-Based Hydrogels Intended for Vascular Graft Development
verfasst von:
Audrey Aussel, Alexandra Montembault, Sébastien Malaise, Marie Pierre Foulc, William Faure, Sandro Cornet, Rachida Aid, Marc Chaouat, Thierry Delair, Didier Letourneur, Laurent David, Laurence Bordenave
Erschienen in:
Journal of Cardiovascular Translational Research
|
Ausgabe 5-6/2017
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Abstract
Vascular grafts made of synthetic polymers perform poorly in cardiac and peripheral bypass applications. In these applications, chitosan-based materials can be produced and shaped to provide a novel scaffold for vascular tissue engineering. The goal of this study was to evaluate in vitro the mechanical properties of a novel chitosan formulation to assess its potential for this scaffold. Two chitosan-based hydrogel tubes were produced by modulating chitosan concentration. Based on the standard ISO 7198:1998, the hydrogel tubes were characterized in vitro in terms of suture retention strength, tensile strength, compliance, and burst pressure. By increasing chitosan concentration, suture retention value increased to reach 1.1 N; average burst strength and elastic moduli also increased significantly. The compliance seemed to exhibit a low value for chitosan tubes of high concentration. By modulating chitosan concentration, we produced scaffolds with suitable mechanical properties to be implanted in vivo and withstand physiological blood pressures.