Introduction
Patients and methods
Study population
Assessment of depression
Antidepressant usage
Statistics
Results
Study population
IFNB-1b 500 µg | IFNB-1b 250 µg | GA | Total | |
---|---|---|---|---|
n = 899 |
n = 897 |
n = 448 |
N = 2244 | |
Duration of disease | ||||
N
| 899 | 896 | 448 | 2243 |
Mean (range, SD), years | 5.4 (0–33, 5.8) | 5.3 (0–42, 5.8) | 5.1 (0–29, 5.6) | 5.3 (0–42, 5.8) |
Age at onset | ||||
N
| 899 | 896 | 448 | 2243 |
Mean (range, SD), y | 31.1 (9–55, 9.2) | 31.1 (10–53, 9.2) | 30.6 (8–55, 9.0) | 31.0 (8–55, 9.1) |
Number of relapses during the previous year | ||||
N
| 899 | 896 | 448 | 2243 |
Mean (range, SD), | 1.6 (0–8, 0.8) | 1.6 (1–5, 0.7) | 1.6 (0–5, 0.8) | 1.6 (0–8, 0.7) |
Total number of previous relapses | ||||
N
| 894 | 888 | 448 | 2230 |
Mean (range, SD) | 3.5 (1–30, 2.6) | 3.5 (1–30, 2.7) | 3.7 (1–21, 2.6) | 3.5 (1–30, 2.6) |
Depression assessed by BDI-II
Screening BDI-II score ≤ 13 | Screening BDI-II score ≥ 14 | |
---|---|---|
n = 659 |
n = 232 | |
Female | ||
n/N
| 479/659 (72.7 %) | 181/232 (78.0 %) |
p value | 0.1175 | |
Caucasian | ||
n/N
| 577/658 (87.7 %) | 195/231 (84.4 %) |
p value | 0.2141 | |
Age | ||
N
| 659 | 232 |
Mean (range, SD), years | 38.0 (18–57, 9.1) | 38.0 (18–55, 9.0) |
p value | 0.8577 | |
Duration of disease | ||
N
| 659 | 232 |
Mean (range, SD), years | 4.7 (0–42, 5.8) | 4.9 (0–32, 5.7) |
p value | 0.4159 | |
Relapse rate in the previous 2 years | ||
N
| 657 | 232 |
Mean (range, SD) | 1.9 (1.0–10.0, 1.0) | 2.2 (1.0–15.0, 1.3) |
p value | 0.0017 | |
Two or more relapses in the previous 2 years | ||
n/N
| 433/657 (65.9 %) | 173/232 (74.6 %) |
p value | 0.0173 | |
EDSS | ||
N
| 651 | 227 |
Mean (range, SD) | 2.0 (0–5.5, 1.1) | 2.7 (0–6.0, 1.2) |
p value | <0.0001 | |
T2 lesion volume (cm3) | ||
N
| 657 | 230 |
Mean (range, SD) | 7.0 (0.1–72.7, 8.4) | 6.6 (0.1–102.0, 9.6) |
p value | 0.2312 | |
T1-hypointense lesion volume (cm3) | ||
N
| 648 | 227 |
Mean (range, SD) | 1.2 (0–26.1, 2.5) | 1.1 (0–39.1, 2.9) |
p value | 0.3305 | |
One or more Gd-enhancing lesions | ||
n/N
| 295/659 (44.8 %) | 82/232 (35.3 %) |
p value | 0.0134 | |
Gd-enhancing lesion volume (cm3) | ||
N
| 651 | 229 |
Mean (range, SD) | 0.22 (0–6.7, 0.6) | 0.16 (0–5.8, 0.5) |
p value | 0.0163 | |
Normalized brain volume (cm3) | ||
N
| 648 | 228 |
Mean (range, SD) | 1502.9 (1171–1804, 106.7) | 1494.7 (1142–1764, 103.2) |
p value | 0.3121 |