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01.12.2016 | Original basic research | Ausgabe 1/2016 Open Access

Thrombosis Journal 1/2016

Incidence of venous thromboembolism in France: a retrospective analysis of a national insurance claims database

Thrombosis Journal > Ausgabe 1/2016
Stéphane Bouée, Corinne Emery, Adeline Samson, Julie Gourmelen, Cécile Bailly, François-Emery Cotté
Wichtige Hinweise

Competing interests

AS, CB and FEC are employees of BMS. SB and CE are employees of CEMKA Eval, a Health Economics Consultancy, who received fees from BMS for data management and data analyses. JG is an employee of INSERM (French Institute of Health and Medical Research).

Authors’ contributions

SB and FEC developed the hypotheses and conceived the analysis plan. CE and JG performed the statistical analyses. All authors have had full access to data and contributed to the analysis and interpretation of the study results. All authors participated in the preparation and the revision of the manuscript and agree to be accountable for all aspects of the work. All authors approved the submission of this final draft.



Data estimating the annual incidence of venous thromboembolism (VTE) in France, taking into account both hospital and community settings, are very lacking.
This study aimed to estimate the annual incidence of VTE (pulmonary embolism (PE) and deep vein thrombosis (DVT)) in France in 2011 in “real world” population.


This was a longitudinal insurance claims study of the incidence of VTE in France over 2 years (2010 and 2011). The data analysis was performed using the EGB (Echantillon Généraliste des Bénéficiaires) database, a randomly selected sample of the French national insurance database (CNAMTS) which covers 77 % of the population. All adult patients experiencing a VTE event during the study period were analysed. Recurrence rate of VTE and all-cause mortality rate were also estimated over a 12-month follow-up period.


The estimated annual incidence of VTE in France was 184.0 per 100 000 subjects, corresponding to a total of 119 670 events countrywide. The estimated incidence of DVT and PE were respectively 119.8 and 64.2 per 100 000 subjects. Annual recurrence of VTE was reported in 5.5 % (n = 99) patients, with a significantly higher recurrence rate in patients with PE than those with DVT (p = 0.02). Overall, 6.2 % (n = 112) of patients had died over the 12-month follow-up (respectively 10.2 and 7.7 % of patients with DVT and PE).


To our knowledge, this analysis is the first to estimate the annual incidence of VTE in France using exhaustive data from the EGB database. This has allowed the incidence of DVT in the community to be documented, which to date has not been characterised. Previous studies in France have been limited to the hospital setting and have yielded incidence rates comparable to ours.


This analysis is the first to estimate the annual incidence of VTE in France using exhaustive data from the EGB database. This study showed that the incidence and the burden of the disease remains elevated.
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