Findings
Background
Materials and methods
Results
C. jejuni induces proinflammatory cytokines in the spleen and large intestine at an earlier time point than in the liver and small intestine
Organ | Group | Day 1 | Day 3 | Day 5 | Day 10 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TNF-α | IL-1 | IL-2 | TNF-α | IL-1 | IL-2 | TNF-α | IL-1 | IL-2 | TNF-α | IL-1 | IL-2 | ||
Spleen | Test | 1042 (±32) * | 270 (±59) | 153 (±39)* | 478 (±340) | 861 (±387)* | 181 (±16) | 114 (±16) | 1094 (±208) * | 70 (±39) | 138 (±26) | 852 (±183) | 78 (±19) |
Control | 245 (±31) | 814 (±262) | 87 (±27) | 1045 (±57) | 319 (±89) | 105 (±51) | 218 (±65) | 717 (±62) | 170 (±92) | 182 (±16) | 1186 (±381) | 55 (±13) | |
Large intestine | Test | 110 (±59)* | 111 (±12) | 471 (±655) | 20 (±5) | 147 (±127) | 1634 (±918) | 13 (±3) | 161 (±40)* | 5752 (±1251)* | 6 (±7) | 101 (±35) | ND |
Control | 13 (±6) | 141 (±10) | 5416 (±1057) | 109 (±61) | 144 (±59) | 1707 (±739) | 15 (±11) | 62 (±47) | 2216 (±705) | 16 (±1) | 159 (±44) | ND | |
Liver | Test | 186 (±17) | 50 (±21) | 256 (±129) | 4581 (±4244) | 133 (±33)* | 1209 (±745)* | 3860 (±1000) | 118 (±34) | 389 (±69) | ND | 126 (±7) | 64 (±22) |
Control | 4567 (±1992) | 73 (±25) | 718 (±297) | 4425 (±992) | 79 (±26) | 458 (±116) | 4183 (±273) | 142 (±72) | 366 (±102) | ND | 148 (±31) | 55 (±8) | |
Small intestine | Test | 7 (±6) | 12 (±9) | 2483 (±286) | 11 (±2) | 6 (±0) | 2063 (±428)* | 6 (±2) | 12 (±2) | 5427 (±756) | 13 (±3) | 4 (±1) | 3640 (±1737) |
Control | 16 (±13) | 142 (±37) | 7352 (±1909) | 11 (±2) | 11 (±6) | 830 (±335) | 11 (±1) | 112 (±25) | 5012 (±828) | 10 (±5) | 2 (±1) | 6603 (±379) | |
Serum | Test | 101 (±9)* | 55 (±13)* | 8 (±0) | 28 (±39) | 27 (±2) | 8 (±0) | 76 (±54) | 23 (±4)* | 8 (±0) | 45 (±39) | 23 (±1) | 8 (±0) |
Control | 29 (±14) | 8 (±9) | 8 (±0) | 100 (±5) | 16 (±11) | 8 (±0) | 43 (±36) | 3 (±0) | 8 (±0) | 85 (±14) | 28 (±3) | 8 (±0) |
C. jejuni induces anti-inflammatory cytokines in all organs by day 5
Organ | Group | Day 1 | Day 3 | Day 5 | Day 10 | ||||
---|---|---|---|---|---|---|---|---|---|
IL-4 | IL-10 | IL-4 | IL-10 | IL-4 | IL-10 | IL-4 | IL-10 | ||
Spleen | Test | 15277 (±6630) | 314 (±32) * | 22824 (±3489) | 326 (±125) | 40284 (±10363)* | 364 (±38) | 9509 (±3368) | 190 (±129) |
Control | 23230 (±3829) | 239 (±34) | 16706 (±7430) | 354 (±54) | 21164 (±1355) | 433 (±201) | 18770 (±4750) | 130 (±49) | |
Large intestine | Test | 1 (±1) | 2 (±0) | 4 (±3) | 10 (±11) | 31 (±31)* | 103 (±113)* | 5 (±1) | 12 (±3) |
Control | 3 (±1) | 13 (±10) | 6 (±5) | 37 (±6) | 6 (±3) | 13 (±12) | 8 (±2) | 6 (±4) | |
Liver | Test | 4960 (±5721) | 90 (±14) | 15856 (±15787) | 122 (±21) | 13820 (±3241)* | 276 (±45)* | ND | 216 (±14) |
Control | 20819 (±6306) | 148 (±23) | 5033 (±3280) | 147 (±40) | 6380 (±2833) | 138 (±45) | ND | 211 (±68) | |
Small intestine | Test | 15 (±10) | 2 (±0) | 31 (±4)* | 7 (±7) | 19 (±10) | 23 (±15)* | 11 (±3) | 11 (±9) |
Control | 23 (±11) | 2 (±0) | 15 (±9) | 8 (±5) | 23 (±11) | 2 (±1) | 22 (±5) | 6 (±4) | |
Serum | Test | 786 (±194)* | 339 (±70) | 239 (±85) | 152 (±118) | 435 (±70)* | 48 (±31) | 335 (±108) | 113 (±70) |
Control | 323 (±29) | 236 (±118) | 1690 (±123) | 484 (±321) | 284 (±78) | 304 (±157) | 409 (±123) | 323 (±128) |
Discussion
Organ | Observation | Day 1 | Day 3 | Day 5 | Day 10 |
---|---|---|---|---|---|
Spleen | Proinflammatory cytokine | TNF-α, IL-2 | IL-1 | IL-1 | - |
Anti-inflammatory cytokine | IL-10 | - | - | - | |
C. jejuni isolated | Yes | No | No | ND | |
Large intestine | Proinflammatory cytokine | TNF-α | - | IL-1, IL-2 | - |
Anti-inflammatory cytokine | - | - | IL-4, IL-10 | - | |
C. jejuni isolated | Yes | Yes | Yes | ND | |
Liver | Proinflammatory cytokine | - | IL-1, IL-2 | - | - |
Anti-inflammatory cytokine | - | - | IL-4, IL-10 | - | |
C. jejuni isolated | Yes | No | No | ND | |
Small intestine | Proinflammatory cytokine | - | IL-2 | - | - |
Anti-inflammatory cytokine | - | IL-4 | IL-10 | - | |
C. jejuni isolated | Yes | Yes | Yes | ND | |
Serum | Proinflammatory cytokine | TNF-α, IL-1 | - | IL-1 | - |
Anti-inflammatory cytokine | IL-4 | - | IL-4 | - | |
C. jejuni isolated | Yes | No | No | ND |