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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Pulmonary Medicine 1/2015

Infection control knowledge, beliefs and behaviours amongst cystic fibrosis patients with epidemic Pseudomonas aeruginosa

Zeitschrift:
BMC Pulmonary Medicine > Ausgabe 1/2015
Autoren:
R. Somayaji, B. Waddell, M. L. Workentine, M. G. Surette, N. P. Brager, H. R. Rabin, M. D. Parkins
Wichtige Hinweise

Competing interests

No author reports conflict pertaining to the above work. Drs Parkins and Rabin have sat on advisory boards for Gilead Sciences, Novartis, Roche, and Vertex. Drs Parkins, Rabin and Surette have received research support from Gilead Sciences.

Authors’ contributions

P, S and R were responsible for the inception of the project and securing funding. P and S were responsible the conduct of the project and wrote the manuscript. W and BW were responsible for bacterial strain typing. P and S contributed to data collection and analysis. All authors contributed to the final revised manuscript. All authors have reviewed the final manuscript and agree to its content.

Abstract

Background

Epidemic P. aeruginosa (ePA) infections are common in cystic fibrosis (CF) and have been associated with accelerated clinical decline. Factors associated with ePA are unclear, and evidence based infection control interventions are lacking.

Methods

We prospectively collect all bacterial pathogens from adult CF patients. We performed PA strain typing on retrospectively collected enrolment samples and recent isolates to identify patients infected with ePA. All patients attending our clinic were approached to complete a survey on infection control knowledge, beliefs and exposures. We analyzed responses of those with ePA relative to the entire cohort without ePA as well as those infected with unique strains of P. aeruginosa to assess for risk factors for ePA and differences in infection control knowledge, beliefs or behaviours.

Results

Of 144 participants, 30 patients had ePA (two Liverpool epidemic strain, 28 Prairie epidemic strain), 83 % of which had established infection prior to transition to the adult clinic. Risk of concomitant infecting pathogens was no different between groups although, Staphylococcus aureus and non-tuberculous mycobacteria were less common in those with ePA. Patients with ePA were more likely to have attended CF-camp and have a history of CF fundraising. Patients with ePA did not differ with respect to beliefs regarding pathogens or transmission risk, except they believed indirect contact posed little risk. Furthermore, patients with ePA were more likely to continue to associate with others with CF despite extensive counselling. Use of peer-peer online networking was minimal in both groups.

Conclusion

Infections with ePA are closely linked to past exposures, now routinely discouraged. As socialization is the greatest risk factor for ePA, infection control strategies for ePA must focus on discouraging face-to-face interactions amongst CF patients. As peer support remains a desire amongst patients, investment in technologies and strategies that enable indirect communication and support are required.
Literatur
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