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03.01.2023 | Review Article

Influence of hormones in multiple sclerosis: focus on the most important hormones

verfasst von: Alireza Soleimani, Sajjad Ghane Ezabadi, Nora Möhn, Zahra Moghimi Esfandabadi, Zahra Khosravizadeh, Thomas Skripuletz, Maryam Azimzadeh

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2023

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Abstract

Hormonal imbalance may be an important factor in the severity of multiple sclerosis (MS) disease. In this context, hormone therapy has been shown to have immunoregulatory potential in various experimental approaches. There is increasing evidence of potentially beneficial effects of thyroid, melatonin, and sex hormones in MS models. These hormones may ameliorate the neurological impairment through immunoregulatory and neuroprotective effects, as well as by reducing oxidative stress. Expanding our knowledge of hormone therapy may be an effective step toward identifying additional molecular/cellular pathways in MS disease. In this review, we discuss the role of several important hormones in MS pathogenesis in terms of their effects on immunoregulatory aspects and neuroprotection.

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Titel: Influence of hormones in multiple sclerosis: focus on the most important hormones
verfasst von: Alireza Soleimani
Sajjad Ghane Ezabadi
Nora Möhn
Zahra Moghimi Esfandabadi
Zahra Khosravizadeh
Thomas Skripuletz
Maryam Azimzadeh
Publikationsdatum: 03.01.2023
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 3/2023
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-022-01138-7

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