Background
Public health care reform in any country is a massive challenge complicated by the need to maintain high medical quality and optimize resource allocation. China medical and pharmaceutical system reform, referred to as “the new health care reform”, was launched in April 2009 aiming to create universal health coverage and promote quality of medical services [
1]. China’s public health institutions are managed in a hierarchical model composed of primary, secondary and tertiary hospitals; this hierarchization is also reflected in the whole process of health care reform. As the most important part of this reform, China’s National Essential Medicines Policy (NEMP) was established in primary hospitals after the first stage of reform. To expanding the national essential medicines coverage, the zero-make-up policy has being carried out. It’s a national reform by sale drugs at ex-factory price, which the profits of medical institutions should be borne by the government to reduce the cost for patients [
2]. After implementing the zero-mark-up policy in the essential medicine system, the average cost per clinical visit and drug cost per prescription has decreased [
3]. All government-run primary healthcare institutions were directed to prescribe only essential medicines, sold under the zero-mark-up policy based on cost from procurement to retailer [
4] . Further, secondary (county-level) and tertiary (upper-level) hospitals are required to prescribe essential medicines preferentially and encouraged to follow the zero-mark-up policy [
5]. County public hospitals are the main medical institutions that provide health service for urban and rural populations. They have become important links from the reform of primary medical institutions to the overall implementation in China. Have there been any significant changes of the physicians’ prescription behaviors in selecting essential medicine in county hospitals? If so, has this change met the expectations of policy design? These are all issues that should be of concern.
Anhui Province was one of the earliest provinces to implement these reforms, establishing graded diagnosis and treatment systems, zero-mark-up policy for medicines, and a “two-envelop” drug bidding procurement system to separate bidding from and commercial activities [
6,
7]. Anhui health care reform model is very specific and understandable for China’s health system which has represented pilot policies later adopted throughout China. The previous study analyzed the use of essential medicines in county public hospitals during years 2011 to 2013 before and after the national health care reform in Anhui Province. Surprisingly, results show essential medicine consumption in primary health care institutions was less than expected [
8]. This indicates county public hospitals may be neglecting proper clinical use of essential medicines.
At present, influencing factors of essential medicine usage in county public hospitals have not been studied. Based on results of these pre-surveys our current study used county public hospitals of Anhui Province as the study sample and explored why insufficient attention has been paid on essential medicines in upper-level hospitals. Hope to provide decision-making guidelines and methodological structure to ensure rational use of essential medicines in China health care system.
Discussion
The WHO recommends an essential medicine system for developing countries to meet the requirements of basic medical security, and to provide indicators for promoting the quality and safety of clinical drug use. In this regard, China’s national essential medicine system was established as the most important component of healthcare reform since 2009. After implementation at primary health institutions, the NEMP was expanded to county hospitals beginning in 2012, they became key institutions to test reform consequences [
20]. Many previous studies focused on the effects of NEMP at primary hospitals [
21‐
23], but few have reported effects at secondary and tertiary hospitals that treat the majority of patients in China and account for a large proportion of drug consumption. In order to consistently serve patients while providing high-quality pharmaceutical service, secondary and tertiary hospitals need encouragement to use essential medicines.
An important issue is whether essential medicines are being prioritized as the new reform policy declares in senior hospitals. Our previous research showed that physicians in county hospitals were under prescribing essential medicines [
24]. Given that Anhui Province is representative of China’s health care reform, we used it to analyze the key factors influencing the priority usage of essential medicines.
We used TPB to create the theoretical framework to explore the correlations among the key variables, including attitude, PBC, SNs and physicians’ intention. We found the TPB model was suitable for explaining the physicians’ intentions for prescribing essential medicines. After analyzing the reliability and validity of the questionnaire, we readjusted the questionnaire statements. Results supported our hypothesis that physicians’ attitudes, PBC and SNs were significant predictors for physicians’ intention to prescribe essential medicines. However, PBC didn’t significantly affect actual behavior to prioritize essential medicines. In general, physicians in sample hospitals showed a passive attitude to providing essential medicines. Through qualitative face-to-face interviews and quantitative analysis, we evaluated 26 observable indicators, and in view of the results we would like to make the following proposals.
There are three kinds of medical insurance in China; namely, urban employee basic medical insurance (UEBMI), urban resident basic medical insurance (URBMI), and the new rural co-operative medical system (NRCMS). Each has its own drug reimbursement list. All essential medicines are included in Class A of the UEBMI list, which means a higher reimbursement of essential medicines than other medicines. The study results indicate that physicians in the county medical institutions preferred to prescribe medicines in the medical insurance catalog. Due to the understanding of medical insurance policy is not clear enough among physicians in county hospitals, and the medical insurance catalog is inconsistent with EM cataloy. Meanwhile, a lack of NEMP comprehension and poor knowledge of essential medicine list (EML) significantly diminished physicians’ intention to select essential medicines as the first choice, they showed less interest for prescribing essential medicine (standardized coefficient was 0.89, 0.72; respectively).
In the present study we identified SNs and PBC as significant and positive predictors of physicians’ intention to prescribe EM. Several important indicators, such as “hospitals promote the EM system (0.83)”, “application of hospital formulary (0.87)”, and “access to EM information (0.82)”, may explain these findings. Effective communication in hospitals plays a major role in physicians’ decision to prescribe EM [
25,
26]. It’s critical to establish an effective communication mechanism for NEMP, one that defines coherent criteria for selection of an essential medicine as directors aim to improve quality and safety of drug use. Shanlian Hu [
27] suggested the criteria for selecting essential medicines should satisfy the following conditions: designated for prevention and treatment for diseases; quality, safety and clinical efficacy; reasonably priced; convenient to use; and balance between chemical, biological, and traditional Chinese medicines.
Our data show provisions of essential medicines in hospital pharmacies is highly correlated with physicians’ perceived behavior. At present, the bidding prices of essential medicines were lower than actual prices due to the “Two Envelope Selective Tender System” [
27]. Physicians didn’t prescribe essential medicines preferentially, the procurement volume was small, tendering used a price–volume agreement system that may persuade the pharmaceutical manufacturers to abandon supplying medicines, thus a shortage of medicines will occur. This phenomenon has a significant influence on the clinical quality and safety, and might deepen physicians’ unsatisfaction towards the essential medicine system. During the structural questionnaire interview, most physicians suggested integrating the drug shortage report into the drug bidding system to incorporate pharmaceutical manufacturers’ credit information system. This would ensure stable provisions of essential medicines in hospital pharmacies.
The effectiveness of the essential medicines’ priority use in the range of public hospitals is ultimately reflected in the behavior of the physicians in prescribing essential medicines. PBC has significantly positive effects on physicians’ intention to prescribe essential medicines. The observable indicator, “recognition of the quality of essential medicine”, indicated part of the reason why essential medicine was considered basic and low-standard product. In China, adjustments to the essential medicine list are made by experts, and the physicians are not knowledgeable on the clinical effects of essential medicines. Consequently, these findings underscore the importance of evidence-based evaluation and dynamic adjustments to the essential medicine list. Drug utilization data and cost-effectiveness analysis based on real world data should be routinely applied in the evaluation of national drug policy (NDP), especially for physicians’ intention for prescription.
Although priority usage of essential medicines is encouraged by the new healthcare reform, it is not mandatory in upper-level hospitals. We used a structural equation to analyze the key factors influencing the priority usage of essential medicines. In order to clarify the main factors affecting the implementation of the essential medicine system in county-level public hospitals at this stage, the repeated variables were deleted, and the key variables were retained during correction model according to the path coefficient. These findings offer insight into rational use of essential medicines comprehensively in public hospitals, and provide a novel methodology for decision-making during the process of public hospital reform.
Limitation
This study has some limitations. First, although the structural questionnaire interview avoided recall bias and ensured quality of investigation, a small group of respondents showed a lack of interest in the NEMP issue, which resulted in an overall response rate of 80.57% and relatively small sample size. Second, this study focused on only county level hospital, although it reflected the current situation of health care reform, however, this population-based analysis should be conducted in other provinces and the tertiary hospitals to improve the universality of the research results. We are planning more widespread investigations in further studies.
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